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By deploying CRISPR to make the smallest mutations, researchers are learning how subtle changes to genes contribute to disease.
In children with certain autism mutations, the diversity and severity of symptoms are often related to the identity and properties of gene units, called exons, targeted by the mutations.
The most detailed analysis to date of CRISPR genome editing in human embryos finds a significant risk of chromosomal abnormalities when using the technique at the earliest stage of human development.
Columbia researchers have uncovered an array of new genes that cause stillbirth, significantly increasing the understanding of the genetic foundations of a common, but little studied, condition.
- April 2, 2020
Based on the book by Columbia oncologist Siddhartha Mukherjee, the documentary also features Wendy Chung, David Goldstein, Samuel Sternberg, and Nancy Wexler. The two-part series airs April 7 and 14.
- August 15, 2019
By participating in one of the world’s largest genetic studies, New Yorkers will help bring precision medicine to their communities, Columbia’s David Goldstein explains.
- September 17, 2018
A new study finds that regulatory gene variants can affect the severity of a genetic disease among people with the same protein-coding mutation.
- April 23, 2018
Lorraine S. Symington, PhD, the Harold S. Ginsberg Professor of Microbiology & Immunology, has been elected to the American Academy of Arts and Sciences.
- April 19, 2018
A new computer algorithm deciphers DNA’s most well-kept secrets and may help researchers find hidden links between genes and disease.
- November 23, 2017
Microscopic data recorder takes advantage of CRISPR to monitor biological surroundings.
- October 2, 2017
Jeffrey Hall, Michael Rosbash, and Michael Young were awarded the 2017 Nobel Prize in Physiology or Medicine for their discoveries of molecular mechanisms controlling circadian rhythm.