Researchers at Columbia University College of Dental Medicine have engineered exosomes to carry CRISPR, significantly enhancing the delivery of genome editing components to specific cells and tissues.
Including BRCA1 testing with prenatal carrier screening could identify people at risk of breast, ovarian, and pancreatic cancer at a time when cancer screening could save their lives.
Columbia genome engineers are designing a CRISPR-based gene therapy with potential to prevent blindness in anyone with retinitis pigmentosa, a condition caused by more than 80 different genes.
Many Black Americans thought to have a high risk of developing kidney disease possess a genetic variant that eradicates the extra risk, a new study from Columbia researchers has found.
Columbia University Medical Center (CUMC) is one of 50 institutions selected nationwide from more than 700 applications for a “Provocative Questions” grant from the National Cancer Institute (NCI).
A study by Columbia researchers Judith Miné-Hattab, PhD, and Rodney Rothstein, PhD, found that after a double-strand break in DNA, the mobility of both the broken segment and other, unbroken, chromosomes is greatly increased.
Richard S. Mann, PhD, and colleagues have solved the longstanding puzzle of why a single transcription factor can turn on many genes in a test tube, but only a few genes in a live organism.