Columbia genome engineers are designing a CRISPR-based gene therapy with potential to prevent blindness in anyone with retinitis pigmentosa, a condition caused by more than 80 different genes.
Many Black Americans thought to have a high risk of developing kidney disease possess a genetic variant that eradicates the extra risk, a new study from Columbia researchers has found.
The genetic changes that made it possible for humans to walk upright have been uncovered in a study that also shows how slight variations in skeletal proportions are linked to arthritis.
Scientists from around the world attended a symposium at Columbia to celebrate the 80th birthday of Tom Maniatis and his contributions to the field of molecular biology.
Columbia University Medical Center (CUMC) is one of 50 institutions selected nationwide from more than 700 applications for a “Provocative Questions” grant from the National Cancer Institute (NCI).
A study by Columbia researchers Judith Miné-Hattab, PhD, and Rodney Rothstein, PhD, found that after a double-strand break in DNA, the mobility of both the broken segment and other, unbroken, chromosomes is greatly increased.
Richard S. Mann, PhD, and colleagues have solved the longstanding puzzle of why a single transcription factor can turn on many genes in a test tube, but only a few genes in a live organism.
Columbia University Medical Center (CUMC) researchers have found the first direct evidence that an acquired trait can be inherited without any DNA involvement.