The Herbert and Florence Irving Institute for Cancer Dynamics will continue its seminar series on the topic of mathematical sciences underpinning cancer research. The monthly seminars take place on the second Wednesday of the month, 2:00-3:00 PM EST. The presentations are open to the Columbia community (in person and online) and to researchers outside Columbia (via Zoom).
On Wednesday, April 8th (2:00 PM ET), IICD welcomes Dr. Andrea Sottoriva from Human Technopole. Seminar hosted by Dr. Sanja Vickovic. The seminar will take place in person in Schermerhorn Hall 603 (Morningside Heights campus). If you wish to attend the seminar remotely, please register using the following link: https://columbiauniversity.zoom.us/meeting/register/HPHK-ZXRSqeujCopJt6h-g
Title: Measuring and Predicting Cancer Evolution with Population Genetics and Machine Learning
Abstract: Cancers evolve following Darwinian rules. Predicting and potentially controlling disease evolution requires appropriate measuring of evolutionary processes in human samples and model systems. This can only be done by combining data collection with computational and mathematical modelling of evolutionary dynamics. Moreover, cancer evolution is not only driven by genetic mutations, but also by epigenetic alterations that, when heritable, can fuel Darwinian selection. I will present approaches that combines multi-omic data collection from patients and patient-derived model systems with computational methods to extract evolutionary biology from cancer genomic and epigenomic data.
Bio: The Sottoriva Lab focusses on deciphering the dynamics of cancer growth, progression and treatment resistance using computational approaches applied to multi-omic data, with the objective of predicting and controlling the disease. We also develop experimental evolution approaches to study cancer drug resistance, bringing the theory+experiment approach to biology. BSc in Computer Science (University of Bologna, 2006), MSc in Computational Sciences (University of Amsterdam, 2008), PhD in Computational Biology (University of Cambridge, 2012), after postdoctoral work at the University of Southern California, he started his lab at the Institute of Cancer Research in London in 2013, where in 2018 he became the Deputy Director of the Centre for Evolution and Cancer and then Director in 2020. He is now the Head of the Computational Biology Research Centre at Human Technopole in Milan, Italy.
If you would like to meet one-on-one (possibly via Zoom) or attend the lunch or dinner with the speaker, please contact the event organizer.