People with a history of cognitively stimulating occupations during their 30s, 40s, 50s, and 60s had a lower risk of mild cognitive impairment and dementia after age 70.
Columbia neuroscientists have identified a genetic mutation that fends off Alzheimer's in people at high risk and could lead to a new way to protect people from the disease.
With funding from the Ultra-rare Gene-based Therapy Network, scientists at Columbia and the n-Lorem Foundation will create tailor-made gene-based therapies for people with rare forms of ALS.
Increased connectivity in the brain's default mode network is a potential precursor, or biomarker, indicating a risk of developing major depressive disorder.
P&S researcher Wendy Chung and colleagues find genetic mutations that explain why many children with congenital heart disease also have neurodevelopmental disorders.
In a case demonstrating the promise of precision medicine, a 20-month-old girl suffering from a rare neurodegenerative disease was diagnosed by exome sequencing and successfully treated.