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Dr. David Hellerstein, a professor of clinical psychiatry at Columbia University Irving Medical Center, said the question comes in many iterations but boils down to: Do antidepressants work?

Dr. David Hellerstein, a co-author and Columbia University research psychiatrist, said those side effects are not surprising given the intensity of the psychedelic experience from the drug.

Katherine Keyes, a professor of epidemiology at Columbia University, said the study painted a stark picture of the problem. “Where the science needs to go,” she said, “is what do we do about it?”