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Ten years ago, a Columbia postdoc identified a simple nutrient that can alleviate Parkinson’s disease symptoms in mice by rewiring the brain. It’s finally being put to the test in people.
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Established two decades ago, the essential tremor brain bank at Columbia has been instrumental in revealing the source and biology of a common but understudied neurodegenerative disorder.
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Variants of the ABCA7 gene accelerate neurodegeneration by reducing the amount of neuropeptide Y, a protein essential for maintaining brain synapses.
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Analysis of 1.6 million brain cells from older adults has captured the cellular changes that occur in Alzheimer’s early stages, revealing potential new targets and routes for prevention.
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