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Columbia scientists caught a malaria parasite in the act of breaking into a blood cell, revealing a parasite machine that reshapes the cell. They then designed a mini-protein to jam it.

Trials of two experimental sickle cell gene therapies—conducted at Columbia and other centers—show that new gene-editing techniques reshape blood cells and free patients from frequent pain crises.

Early discoveries in Lawrence Lustig’s lab helped pave the way for the first FDA-approved gene therapy for hearing loss, which has restored near-normal hearing in children with rare genetic deafness.

A new study that tracks how blood cells develop could help researchers uncover new treatments for aging and some of the most difficult-to-treat blood cancers.