Shan Zha, MD, PhD

Academic Appointments

  • Associate Professor of Pathology and Cell Biology and of Microbiology and Immunology (in the Institute for Cancer Genetics and in the Herbert Irving Comprehensive Cancer Center)
  • James A Wolff Associate Professor of Pediatrics
Shan Zha, MD, PhD

Email: sz2296@cumc.columbia.edu

The Zha lab investigates how defects in DNA repair and DNA damage responses impact normal immune system development, lymphomagenesis, and treatment responses. The lab has developed cutting-edge technologies, including high-throughput translocation sequencing, sing cell-seq, multi-color flow-cytometry, CRISPR-based depletion and activation screens, high-content live-cell imaging, and a collection of over sixty-five unique mouse models, including the serial of mouse models expressing catalytically inactive ATM, ATR, DNA-PKcs, and now PARP1 and PARP2, which revealed unexpected structural function of DNA damage response factors. More details can be found at zhalab.org. We invite committed young scientists to join us in the adventures.

Departments and Divisions

  • Department of Pediatrics
    Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation
  • Department of Pathology & Cell Biology

Centers / Institutes / Programs

  • Herbert Irving Comprehensive Cancer Center

NIH Grants

  • DNADOUBLE-STRAND BREAK REPAIR, CHROMOSOME TRANSLOCATIONS AND CANCER (Federal Gov)

    Apr 1 2020 - Mar 25 2025

    THE CATALYTIC AND NON-CATALYTIC FUNCTIONS OF PARP1 IN CANCER BIOLOGY (Federal Gov)

    Apr 1 2018 - Mar 31 2023

    THESTRUCTURAL FUNCTION OF ATR IN DEVELOPMENT, ONCOGENESIS AND CANCER THERAPY (Federal Gov)

    Apr 1 2017 - Mar 31 2022

    THE ROLE OF ATM IN SUPPRESSION OF LYMOPHOMAS (Federal Gov)

    Feb 1 2017 - Jan 31 2022

    THESTRUCTURAL FUNCTION OF ATR IN DEVELOPMENT, ONCOGENESIS AND CANCER THERAPY (Federal Gov)

    Jul 1 2018 - Jun 30 2021

    DNA-PKCS PHOSPHORYLATION IN DNA REPAIR AND CHROMOSOMAL TRANSLOCATIONS (Federal Gov)

    Dec 1 2014 - Nov 30 2020

    DNA DOUBLE-STRAND BREAK REPAIR, CHROMOSOMES TRANSLOCATIONS AND CANCER (Federal Gov)

    Apr 1 2014 - Mar 31 2020

    DNA-PKCS PHOSPHORYLATION IN DNA REPAIR AND CHROMOSOMAL TRANSLOCATIONS (Federal Gov)

    Dec 1 2014 - Nov 30 2019

    DNA-PKCS PHOSPHORYLATION IN DNA REPAIR AND CHROMOSOMAL TRANSLOCATIONS (Federal Gov)

    Dec 1 2014 - Nov 30 2019

    CANCER CENTER SUPPORT GRANT (Federal Gov)

    Jul 1 2014 - Jun 30 2019

    CANCER CENTER SUPPORT GRANT (Federal Gov)

    Jul 1 2014 - Jun 30 2019

    DNA DOUBLE-STRAND BREAD REPAIR, CHROMOSOME TRANSLOCATIONS AND CANCER (Federal Gov)

    Apr 1 2014 - Mar 31 2019

    DNA DOUBLE-STRAND BREAD REPAIR, CHROMOSOME TRANSLOCATIONS AND CANCER (Federal Gov)

    Apr 1 2014 - Mar 31 2019

    ATM KINASES AS A TUMOR SUPPRESSOR IN DEVELOPING B CELLS (Private)

    Jul 1 2013 - Jun 30 2018

    NON-CATALYTIC FUNCTIONS OF DNA-PK IN DNA REPAIR AND TUMORIGENESIS (Federal Gov)

    Sep 1 2014 - Aug 31 2017

    NON-CATALYTIC FUNCTIONS OF DNA-PK IN DNA REPAIR AND TUMORIGENESIS (Federal Gov)

    Sep 1 2014 - Aug 31 2017

    THE STRUCTURAL FUNCTION OF ART IN DNA REPLICATION AND TUMORIGENESIS (Private)

    Aug 1 2016 - Jul 31 2017

    THE ROLE OF ATM IN SUPPRESSION OF LYMPHOMAS (Federal Gov)

    Feb 1 2011 - Jan 31 2017

    THE KINASE VS STRUCTURE FUNCTION OF ATM IN DNA REPAIR AND TUMOR SUPPRESSION (Private)

    Jan 1 2013 - Dec 31 2016

    ROLES OF XLF AND 53P1 IN DNA REPAIR AND SUPPRESSION OF LYMPHOMA (Private)

    Jul 1 2013 - Jun 30 2016

    TARGET ATM MUTATION FOR CANCER THERAPY (Private)

    Jan 1 2014 - Dec 31 2015

    THE ROLE OF XLF IN HEMATOPOIETIC STEM CELL MAINTENANCE AND FUNCTION (Federal Gov)

    Aug 15 2013 - Jul 31 2015

    THE ROLE OF XLF IN HEMATOPOIETIC STEM CELL MAINTENANCE AND FUNCTION (Federal Gov)

    Aug 15 2013 - Jul 31 2015

    THE ROLE OF ATM KINASE IN SUPPRESSION B CELL LYMPHOMAS (Private)

    Jan 1 2012 - Dec 31 2014

    THE ROLE OF ATM KINASE ACTIVITY IN THE DEVELOPMENT OF LYMPHOID MALIGNANCY (Private)

    Jul 1 2012 - Jun 30 2014

    THE MECHANISM OF CLONAL TRANSLOCATIONS IN PEDIATRIC T-ALL: THE ROLE OF ATM (Private)

    Jul 1 2010 - Jun 30 2013

    THE FUNCTION OF CERNUNNOS IN LYMPHOCYTE DEVELOPMENT AND LYMP HOMAGENESIS (Private)

    Dec 1 2009 - Jun 30 2010

Publications

  1. The cancer-associated ATM R3008H mutation reveals the link between ATM activation and its exchange
    Milanovic M, Houghton LM, Menolfi D, Lee JH, Yamamoto K, Li Y, Lee BJ, Xu J, Estes VM, Wang D, McKinnon PJ, Paull TT, Zha S
    Cancer Res. 2020.
    PMID: 33239428, DOI: 10.1158/0008-5472.CAN-20-2447
  2. Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo
    Shao Z, Lee BJ, Rouleau-Turcotte É, Langelier MF, Lin X, Estes VM, Pascal JM, Zha S
    Nucleic Acids Res. 2020.
    PMID: 32890402, DOI: 10.1093/nar/gkaa718
  3. Dual-Color Plasmonic Nanosensor for Radiation Dosimetry
    Tao Y, Li M, Liu X, Leong KW, Gautier J, Zha S
    ACS Appl Mater Interfaces. 2020.
    PMID: 32337977, DOI: 10.1021/acsami.0c03001
  4. DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
    Shao Z, Flynn RA, Crowe JL, Zhu Y, Liang J, Jiang W, Aryan F, Aoude P, Bertozzi CR, Estes VM, Lee BJ, Bhagat G, Zha S, Calo E
    Nature. 2020.
    PMID: 32103174, DOI: 10.1038/s41586-020-2041-2
  5. CtIP is essential for early B cell proliferation and development in mice
    Liu X, Wang XS, Lee BJ, Wu-Baer FK, Lin X, Shao Z, Estes VM, Gautier J, Baer R, Zha S
    J Exp Med. 2019.
    PMID: 31097467, DOI: 10.1084/jem.20181139
  6. Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA
    Menolfi D, Jiang W, Lee BJ, Moiseeva T, Shao Z, Estes V, Frattini MG, Bakkenist CJ, Zha S
    Nat Commun. 2018.
    PMID: 30559436, DOI: 10.1038/s41467-018-07798-3
  7. Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination
    Crowe JL, Shao Z, Wang XS, Wei PC, Jiang W, Lee BJ, Estes VM, Alt FW, Zha S
    Proc Natl Acad Sci USA. 2018.
    PMID: 30072430, DOI: 10.1073/pnas.1808490115
  8. PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice
    Liu X, Shao Z, Jiang W, Lee BJ, Zha S
    Nat Commun. 2017.
    PMID: 28051062, DOI: 10.1038/ncomms13816
  9. Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors
    Yamamoto K, Wang J, Sprinzen L, Xu J, Haddock CJ, Li C, Lee BJ, Loredan DG, Jiang W, Vindigni A, Wang D, Rabadan R, Zha S
    Elife. 2016.
    PMID: 27304073, DOI: 10.7554/eLife.14709
  10. Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during nonhomologous end-joining
    Jiang W, Crowe JL, Liu X, Nakajima S, Wang Y, Li C, Lee BJ, Dubois RL, Liu C, Yu X, Lan L, Zha S
    Mol Cell. 2015.
    PMID: 25818648, DOI: 10.1016/j.molcel.2015.02.024
  11. Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice
    Yamamoto K, Wang Y, Jiang W, Liu X, Dubois RL, Lin CS, Ludwig T, Bakkenist CJ, Zha S
    J Cell Biol. 2012.
    PMID: 22869596, DOI: 10.1083/jcb.201204098
  12. ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks
    Zha S, Guo C, Boboila C, Oksenych V, Cheng HL, Zhang Y, Wesemann DR, Yuen G, Patel H, Goff PH, Dubois RL, Alt FW
    Nature. 2011.
    PMID: 21160472, DOI: 10.1038/nature09604
  13. Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination
    Li G, Alt FW, Cheng HL, Brush JW, Goff PH, Murphy MM, Franco S, Zhang Y, Zha S
    Mol Cell. 2008.
    PMID: 18775323, DOI: 10.1016/j.molcel.2008.07.017

For a complete list of publications, please visit PubMed.gov