Stefano Fusi, PhD

Academic Appointments

  • Professor of Neuroscience (in the Mortimer B. Zuckerman Mind Brain Behavior Institute)
Stefano Fusi, PhD

The complexity of real world behavior cannot be reduced to a simple mapping between a sensory stimulus and a motor response. Indeed the same stimulus should sometimes lead to different behaviors depending on the situation, the intention of the subject, and the rules imposed by the task to be performed. In many complex tasks we need to go through a series of different inner mental states each representing a particular disposition to behavior. Our group investigates the neural mechanisms which underlie the formation of rule representations (learning) and their expression. In particular we are developing a model of a neural network which encodes the inner mental states as attractor of the neural dynamics. Moreover we study the theory of synaptic mechanisms leading to the abstraction of the rules (learning and memory). In collaboration with experimentalists from different fields we test our ideas on real biological brains.

Departments and Divisions

  • Department of Neuroscience

Lab Locations

  • Jerome L. Greene Science Center

    3227 Broadway
    L6-072
    New York, NY 10027
    Phone:
    (212) 853-0176
    Email:
    sf2237@columbia.edu

Research Interests

  • Cognitive/Systems Neuroscience
  • Computation and Theory
  • Neurobiology of Learning and Memory
  • Theoretical Neuroscience

NIH Grants

  • NEUROPHYSIOLOGY UNDERLYING NEURAL REPRESENTATIONS OF VALUE (Federal Gov)

    Dec 27 2017 - Oct 31 2022

    DECODING EARLY SIGNS OF ALZHEIMER S DISEASE IN THE LATERAL ENTORHINAL CORTEX USING MACHINE LEARNING (Federal Gov)

    Sep 15 2019 - May 31 2021

    THE BEHAVIORAL FUNCTIONS OF UPPER AND LOWER CORTICAL LAYERS (Federal Gov)

    Jul 15 2016 - Apr 30 2021

    CIRCUIT MECHANISMS OF SOCIAL COGNITIVE COMPUTATIONS (Private)

    Oct 1 2015 - Sep 30 2018

    NEUROPHYSIOLOGY UNDERLYING NEURAL REPRESENTATIONS OF VALUE (Federal Gov)

    Feb 1 2007 - Dec 26 2017

    NEUROPHYSIOLOGY UNDERLYING NEURAL REPRESENTATIONS OF VALUE (Federal Gov)

    Feb 1 2007 - Oct 31 2017

    NEUROPHYSIOLOGY UNDERLYING NEURAL REPRESENTATIONS OF VALUE (Federal Gov)

    Feb 1 2007 - Oct 31 2017

    COMPUTATIONAL PRINCIPLES OF MECHANISMS UNDERLYING COGNITIVE FUNCTIONS (Private)

    Jul 1 2014 - Jun 30 2017

    SYSTEMS OF NEUROMORPHIC ADAPTIVE PLASTIC SCALABLE ELECTRONIC S (Federal Gov)

    Oct 24 2008 - Jan 31 2013

    C-LEARNING - LEARNING CONTEXT DEPENDENT BEHAVIOR: NEURAL AND SYNAPTIC MECHANISMS (Private)

    Sep 1 2009 - Aug 31 2011

    NIH DIRECTOR"S PIONEER AWARD (Federal Gov)

    Sep 30 2004 - Jul 31 2011

    A MATHEMATICAL MODEL OF HIPPOCAMPAL NEUROGENESIS TO EXPLAIN THE COMPUTATIONAL INFLUENCE OF ADULT-BORN NEURONS ON BRAIN F (Federal Gov)

    Jul 1 2009 - Jun 30 2011

Publications

  • M. Rigotti, O. Barak, M.R. Warden, X.-J. Wang, N.D. Daw, E.K. Miller, S. Fusi, The importance of mixed selectivity in complex cognitive tasks, Nature 497, 585-590 (2013)
  • A. Roxin, S. Fusi, Efficient Partitioning of Memory Systems and Its Importance for Memory Consolidation, PLoS Comput Biol 9(7): e1003146. doi:10.1371/journal.pcbi.1003146 (2013)
  • O. Barak, M. Rigotti, S. Fusi, The sparseness of mixed selectivity neurons controls the generalization-discrimination trade-off, Journal of Neuroscience 33, 3844-56 (2013)
  • M. Rigotti, D. D. Ben Dayan Rubin, X.-J. Wang and S. Fusi, Internal representation of task rules by recurrent dynamics: the importance of the diversity of neural responses, Frontiers in Computational Neuroscience, 4, doi: 10.3389/fncom.2010.00024 (2010)
  • S. Fusi, P.J. Drew, L.F. Abbott, Cascade models of synaptically stored memories, Neuron, 45, 599-611, (2005)

For a complete list of publications, please visit:
http://www.neurotheory.columbia.edu/Fusi/pubs.html