Rudolph L. Leibel, MD

Academic Appointments

  • Professor of Pediatrics
  • Professor of Medicine

Current Administrative Positions

  • Co-Director, Naomi Berrie Diabetes Center
  • Chief, Division of Pediatric Molecular Genetics
Rudolph L. Leibel, MD

Dr. Leibel's research focuses on the genetics of obesity and noninsulin-dependent diabetes. His laboratory has mapped, cloned, and identified mutations in the obese and fatty genes in rats, mice, and, more recently, in humans. The obese gene encodes leptin, an adipose derived hormone responsible for regulating body weight, whereas the fatty gene encodes the leptin receptor. Currently, his research group is defining the physiological bases by which this and related signaling networks regulate body size and composition. For example, changes in leptin production following reduction in body fat might play a role in the metabolic changes that accompany weight loss in humans. Dr. Leibel's laboratory is also working to isolate additional rodent genes that influence body weight and the susceptibility to noninsulin dependent diabetes mellitus in the context of obesity. Laboratory members have extended their genetic studies to search for similar obesity and diabetes related genes in human families.

Departments and Divisions

  • Department of Pediatrics
    Division of Pediatric Molecular Genetics
  • Department of Medicine
    Division of Endocrinology

Board Certifications

  • Pediatrics

Areas of Expertise

  • Obesity

Education and Training

  • Albert Einstein College of Medicine - Yeshiva University
  • Internship: Massachusetts General Hospital
  • Residency: Massachusetts General Hospital
  • Residency: Children's Hospital of Boston
  • Fellowship: Massachusetts General Hospital

Locations

  • CUIMC/Russ Berrie Medical Science Pavilion

    1150 St. Nicholas Avenue
    Floor 6
    New York, NY 10032
    For new and current patient appointments, call:
    (212) 851-5257
    Phone:
    (212) 851-5315

Centers / Institutes / Programs

  • Institute of Human Nutrition

Provider Affiliations

  • NewYork-Presbyterian Morgan Stanley Children's Hospital
  • NewYork-Presbyterian / Columbia University Irving Medical Center

This provider does not accept new patients

Lab Locations

  • CUIMC/Russ Berrie Medical Science Pavilion

    1150 St. Nicholas Avenue
    Floor 6
    New York, NY 10032
    Phone:
    (212) 851-5315

Research Interests

  • Genetics of obesity and noninsulin-dependent diabetes

NIH Grants

  • COLUMBIA DIABETES RESEARCH CENTER (Federal Gov)

    Jul 6 2018 - Jan 31 2023

    THE MOLECULAR GENETIC ANALYSIS OF HUMAN OBESITY (Federal Gov)

    Sep 24 2016 - Aug 31 2021

    SHORT TERM TRAINING GRANT (Federal Gov)

    May 1 2016 - Apr 30 2021

    NEW YORK OBESITY RESEARCH CENTER (Federal Gov)

    Apr 15 2016 - Mar 31 2021

    NEW YORK OBESITY RESEARCH CENTER (Federal Gov)

    Dec 1 1996 - Mar 31 2021

    CONVERTING GUT ENDOCRINE CELLS TO GLUCOSE-RESPONSIVE INSULIN PRODUCING CELLS BY SELECTIVE FOXO1 INHIBITION TO CURE INSULIN-DEPENDENT DIABETES (Federal Gov)

    Apr 1 2020 - Aug 31 2020

    THE REWARDING VALUE OF SUGAR IN THE ABSENCE OF SWEET TASTE (Federal Gov)

    Sep 1 2015 - Aug 31 2020

    THE REWARDING VALUE OF SUGAR IN THE ABSENCE OF SWEET TASTE (Federal Gov)

    Sep 1 2015 - Aug 31 2020

    FORKHEAD BIOTHERAPEUTICS SRA (Private)

    Dec 15 2017 - Aug 31 2020

    THE REWARDING VALUE OF SUGAR IN THE ABSENCE OF SWEET TASTE (Federal Gov)

    Sep 1 2015 - Aug 31 2020

    CENTER FOR IDENTIFICATION AND STUDY OF INDIVIDUALS WITH ATYPICAL DIABETES MELLLITUS (Federal Gov)

    Sep 10 2018 - May 31 2020

    DIABETES AND ENDOCRINOLOGY RESEARCH CENTER (Federal Gov)

    Mar 15 2013 - May 9 2020

    NYCT: MOLECULAR ANALYSES OF THE CAUSES OF DIABETES AND ITS COMPLICATIONS (Private)

    Jan 1 2019 - Dec 31 2019

    FUNCTIONAL IMAGING AND EATING BEHAVIOR AMONG FTO GENOTYPES IN PRE-OBESES CHILDREN (Federal Gov)

    Sep 18 2013 - Aug 31 2019

    WALLKILL (Private)

    Jan 1 2018 - Dec 31 2018

    FUNCTIONAL IMAGING AND EATING BEHAVIOR AMONG FTO GENOTYPES IN PRE-OBESES CHILDREN (Federal Gov)

    Sep 18 2013 - Aug 31 2018

    FUNCTIONAL IMAGING AND EATING BEHAVIOR AMONG FTO GENOTYPES IN PRE-OBESES CHILDREN (Federal Gov)

    Sep 18 2013 - Aug 31 2018

    DIABETES AND ENDOCRINOLOGY RESEARCH CENTER (Federal Gov)

    Mar 15 2013 - Jan 31 2018

    DIABETES AND ENDOCRINOLOGY RESEARCH CENTER (Federal Gov)

    Mar 15 2013 - Jan 31 2018

    DIABETES AND ENDOCRINOLOGY RESEARCH CENTER (Federal Gov)

    Mar 15 2013 - Jan 31 2018

    HELMSLEY TRUST DIABETES CELL REPOSITORY (Private)

    Jan 1 2015 - Dec 31 2017

    MOLECULAR ANALYSES OF THE CAUSES OF DIABETES AND ITS COMPLICATIONS (Private)

    Jan 1 2017 - Dec 31 2017

    CLINICAL INVESTIGATION OF EFFICACY OF TAUROURODEOXYCHOLIC ACID (TUDCA) TO ENHANCE PANCREATIC BETA CELL SURVIVAL IN TYPE 1 DIABETES BY REDUCING ER STRESS (Private)

    Oct 1 2014 - Sep 30 2017

    INVESTIGATING THE ROLE OF LLDR2 IN HEPATIC STEATGOSIS AND ENDOPLASMIC RETICULUM STRESS (Private)

    Sep 1 2015 - Aug 31 2017

    REDUCED PROHORMONE PROCESSIN(PROHORMONE CONVERTASE 1 HYPOACTIVITY) AS A MECHANISM FOR PRADER-WILLI SYNDROME. PRE-CLINICAL ANALYSES. (Private)

    Jul 15 2016 - Jul 14 2017

    PEDIATRIC SCIENTIST DEVELOPMENT PROGRAM (PSDP) K12 (Federal Gov)

    Jul 1 2015 - Jun 30 2017

    STUDY OF CODING VARIANTS IN HUMAN OBESITY AND THEIR FUNCTIONAL CHARACTERIZATION USING HUMAN IPSC-DERIVED CELLULAR MODELS (Federal Gov)

    Sep 17 2016 - Jun 30 2017

    A TWIN STUDY OF OBESITY PATHOGENESIS USING FM (Federal Gov)

    Sep 1 2015 - Aug 31 2016

    DIABETES STEM CELLS (Private)

    Sep 1 2010 - Aug 31 2016

    PEDIATRIC SCIENTIST DEVELOPMENT PROGRAM (PSDP) K12 (Federal Gov)

    Jul 1 2015 - Jun 30 2016

    TO FUNCTIONALLY EVALUATE POSSIBLE DISEASE-CAUSING VARIANTS IDENTIFIED IN WES/WGS TO DETERMINE PATHOGENICITY OF RARE VARIANTS AND DISEASE MECHANISM. (Private)

    Jul 1 2014 - Jun 30 2016

    COLLABORATIVE RESEARCH PROGRAM RELATING TO THE STUDY OF GENETIC DISEASES THROUGH WHOLE EXOME/GENOME SEQUENDING (Private)

    Jul 1 2014 - Jun 30 2016

    THE ROLE OF ENDOPLASMIC RETICULUM STRESS IN DIABETIC BETA CELL FAILURE (NY State Gov)

    Jun 1 2014 - May 31 2016

    SHORT-TERM TRAINING: STUDENTS IN HEALTH PROFESSIONAL SCHOOLS (Federal Gov)

    May 1 1981 - Apr 30 2016

    NEW YORK NUTRITION OBESITY RESEARCH CENTER (Federal Gov)

    Dec 1 1996 - Mar 31 2016

    MOLECULAR ANALYSES OF THE CAUSES OF DIABETES AND ITS COMPLICATIONS (Private)

    Jan 1 2015 - Dec 31 2015

    MOLECULAR ANALYSES OF THE CAUSES OF DIABETES AND ITS COMPLICATIONS (Private)

    Jan 1 2015 - Dec 31 2015

    MENTOR-BASED POSTDOCTORAL FELLOWSHIP AWARD (Private)

    Jul 1 2011 - Jun 30 2015

    MOLECULAR GENETIC ANALYSIS OF HUMAN OBESITY (Federal Gov)

    Dec 1 2008 - Nov 30 2014

    THE ROLE OF SNORD116@ IN PRADER-WILLI SYNDROME (Private)

    Sep 1 2013 - Aug 31 2014

    METABOLIC ADAPTATION AND CHANGES IN CENTRAL NERVOUS SYSTEM CIRCUITRY IN WEIGHT-PERTURBED C57BL/6J MICE (Private)

    Jun 16 2008 - Nov 30 2013

    BODY COMPOSITION STUDIES AND EATING BEHAVIOR (Private)

    Aug 22 2013 - Nov 21 2013

    LEPTIN IN HUMAN ENERGY AND NEUROENDOCINE HOMEOSTASIS (Federal Gov)

    Jul 1 2003 - Sep 30 2013

    USE OF STEM CELL-DERIVED NEURONS TO IDENTIFY THE MOLECULAR BASIS OF THE PRADER-WILLI SYNDROME (Private)

    Jun 1 2012 - Aug 31 2013

    USING STEM CELLS TO INVESTIGATE HUMAN OBESITY MUTATIONS AND SUSCEPTIBILITY ALLELES (NY State Gov)

    Sep 1 2010 - Aug 31 2013

    UNDERSTANDING THE MOLECULAR PATHOGENESIS OF BETA CELL FAILURE IN DIABETES (Private)

    Dec 1 2012 - May 31 2013

    CLONING OF A TYPE 2 DIABETES MODIFIER IN OBESE MICE (Federal Gov)

    Sep 30 2003 - Apr 30 2013

    NYORC MOLECULAR GENETICS/MOLECULAR BIOLOGY CORE (Federal Gov)

    Jun 10 2011 - Mar 31 2013

    CELL BANK FROM DIABETES PATIENTS (Private)

    Aug 1 2009 - Jan 31 2013

    UNDERSTANDING INTRINSIC BETA CELLS DEFECTS IN MONOGENIC FORMS OF DIABETES- A POSITIVE CONTROL FOR CELL-AUTONOMOUS BETA CELL DEFECTS (Private)

    Aug 1 2009 - Jan 31 2013

    GENERATION OF ES CELLS BY SOMATIC CELL NUCLEAR TRANSFER (SCNT) AND COMPARISON OF THEIR FUNCTIONAL ASPECTS TO STEM CELLS CREATED BY IPS (Private)

    Aug 1 2009 - Jan 31 2013

    FORMATION OF ENDOCRINE PANCREAS PROGENITORS (Federal Gov)

    Jul 1 2010 - Jun 30 2012

    A TWIN STUDY OF OBESITY PATHOGENESIS USING FMRI (Federal Gov)

    Jul 19 2010 - Jun 30 2011

    MOLECULAR GENETIC ANALYSIS OF HUMAN OBESITY (Private)

    Jul 1 2007 - Jun 30 2011

    MOLECULAR GENETIC ANALYSIS OF HUMAN OBESITY (Federal Gov)

    Jul 1 2007 - Jun 30 2011

    NEW YORK OBESITY RESEARCH CENTER (Federal Gov)

    Dec 1 1999 - Mar 31 2011

    NEW YORK OBESITY RESEARCH CENTER (Federal Gov)

    Dec 1 1999 - Mar 31 2011

    NYORC MOLECULAR GENETICS/MOLECULAR BIOLOGY CORE (Federal Gov)

    Dec 1 1999 - Mar 31 2011

    NYORC MOLECULAR GENETICS/MOLECULAR BIOLOGY CORE (Federal Gov)

    Apr 1 2010 - Mar 31 2011

    NEW YORK OBESITY RESEARCH CENTER (Federal Gov)

    Dec 1 1999 - Mar 31 2011

    NYORC MOLECULAR GENETICS/MOLECULAR BIOLOGY CORE (Federal Gov)

    Apr 1 2010 - Mar 31 2011

    NYORC MOLECULAR GENETICS/MOLECULAR BIOLOGY CORE (Federal Gov)

    Dec 1 1999 - Mar 31 2011