Academic Appointments
- Professor of Epidemiology
- Robert R. Williams Professor of Nutrition (in Pediatrics)
The major focus of Dr. Deckelbaum’s laboratory is to determine regulatory mechanisms for cell-lipid particle interaction, and cell cholesterol and triglyceride metabolism. Current projects are defining the effects of lipid particle properties on their metabolism in the whole animal, and in cells, via receptor-mediated and receptor-independent pathways. Integrated with these studies are studies on how different lipids, omega-3 and other free fatty acids regulate gene expression and focus on genes and mechanisms affecting atherogenesis, myocardial infarction and stroke. Dr. Deckebaum’s initial research training as a postdoctoral fellow in biophysics using NMR, calorimetry, and X-ray techniques to study the structure of lipoproteins has allowed him throughout his career to understand the importance of physical structure of different lipids in the biochemistry and in the molecular biology of lipids and lipid metabolism. Having been funded continuously for over thirty years by NIH R01s and PPGs focusing on triglyceride emulsions, lipoprotein metabolism, and lipid metabolism in in vitro and in vivo, we have obtained very exciting results over the years showing that EPA/DHA rich diets have the ability to inhibit pathways associated with atherogenesis in four different rodent models. Our laboratory has shown that acute administration of omega-3 fatty acids also provides major neuro- and cardioprotection after stroke and myocardial infarction in rodent models. Of the pre- and postdoctoral trainees Dr. Deckelbaum has mentored over the past 30 years, over 45 now have full-time academic positions at universities or are heading nutrition-related roles in industry and government.
Departments and Divisions
- Department of Pediatrics
Division of Pediatric Gastroenterology, Hepatology, and Nutrition
Board Certifications
- Pediatrics
Areas of Expertise
- Gastroenterology
- Pediatric Gastroenterology
- Nutrition
Languages Spoken
- Hebrew
- French
Education and Training
- McGill University Faculty of Medicine
- Residency: Hadassah University Medical Center, Israel
- Residency: Montreal Children's Hospital
- Fellowship: Boston University
- Fellowship: Massachusetts Institute of Technology
Locations
CUIMC/Presbyterian Hospital and Vanderbilt Clinic
622 West 168th Street
1512
New York, NY 10032- For new and current patient appointments, call:
- (212) 305-5903
- Phone:
- (212) 305-4808
Centers / Institutes / Programs
- Institute of Human Nutrition
Provider Affiliations
- NewYork-Presbyterian / Columbia University Irving Medical Center
- NewYork-Presbyterian Morgan Stanley Children's Hospital
This provider sees pediatric patients
This provider does not accept new patients
Lab Locations
CUIMC/Presbyterian Hospital and Vanderbilt Clinic
622 West 168th Street
1512
New York, NY 10032
Grants
NIH R21 NS109717, RJ Deckelbaum (PI) 08/15/2019-07/31/2021 "n-3 Diglyceride Emulsions: Characterization of a Novel Neuroprotectant"
NIH RO1 NS088197, RJ Deckelbaum (PI) 04/01/15-03/31/20 “Omega-3 Fatty Acids: Acute Neuroprotection via Mitochondria”
NIH 2P30 DK63068-06, D Accili (PI); RJ Deckelbaum (Mentor) 02/01/08-01/31/23 “Diabetes and Endocrinology Center”
NIH T32 DK07647-26, RJ Deckelbaum (Co-PI) 09/01/95-08/31/20 “Graduate Training in Nutrition”
NIH R01 HL141823, A Moran (PI); RJ Deckelbaum (Co-PI) 09/01/18-08/31/23 “Familial hypercholesterolemia screening in children: population impact of phenotype, genotype and cascade approaches”
Private, RJ Deckelbaum (PI) 06/01/16-12/31/19
“Characterization and Effects of an MCT-Fish Oil Intravenous Lipid Emulsion in Rodent Models”
NIH Grants
SYNERGISTIC EFFECTS OF MEDIUM-CHAIN AND OMEGA-3 TRIGLYCERIDES ON CELLULAR OMEGA-3 FATTY ACIDENRICH (Federal Gov)
Jan 10 2020 - Dec 31 2024
FAMILIALHYPERCHOLESTEROLEMIA SCREENING IN CHILDREN: POPULATION IMPACT OF PHENOTYPE, GENOTYPE, AND CASCADE APPROACHES (Federal Gov)
Feb 1 2019 - Apr 30 2023
N-3 DIGLYCERIDE EMULSIONS: CHARACTERIZATION OF A NOVEL NEUROPROTECTANT (Federal Gov)
Aug 15 2019 - Jul 31 2021
OMEGA 3 FATTY ACIDS ACUTE NEUROPROTECTION VIA MITOCHONDRIA (Federal Gov)
Apr 1 2015 - Mar 31 2021
OMEGA 3 FATTY ACIDS ACUTE NEUROPROTECTION VIA MITOCHONDRIA (Federal Gov)
Apr 1 2015 - Mar 31 2020
OMEGA 3 FATTY ACIDS ACUTE NEUROPROTECTION VIA MITOCHONDRIA (Federal Gov)
Apr 1 2015 - Mar 31 2020
CHARACTERIZATION AND EFFECTS OF AN MCT-FISH OIL INTRAVENOUS LIPID EMULSION (Private)
Jun 1 2016 - May 31 2018
CHARACTERIZATION AND OPTIMIZATION OF OMEGA-3 INTRAVENOUS PHOSPHOLIPID STABILIZED DIGLYCERIDE EMULSIONS FOR THE TREATMENT OF ORGAN ISCHEMIA (Private)
Jun 1 2012 - Dec 31 2015
METABOLISM OF INTRAVENOUS LIPID EMULSIONS (Federal Gov)
Apr 1 1988 - Aug 31 2009