Peter A. Sims, PhD

Academic Appointments

  • Associate Professor of Systems Biology (in Biochemistry and Molecular Biophysics and in Systems Biology)

Current Administrative Positions

  • Director, Columbia Single Cell Analysis Core
  • Director, Systems Biology Graduate Studies
Peter A. Sims, PhD

Dr. Sims received in Ph.D. in chemistry from Harvard University where he also conducted postdoctoral research, and has been an Assistant Professor at Columbia since 2012. He has served as Director of Systems Biology Graduate Studies since 2016 and Director of the Columbia Single Cell Analysis Core since 2017.

The Sims Lab at Columbia University Medical Center focuses on the development of new technology for the application of systems biology in biomedicine. We recently developed and applied new experimental and computational methods for cell type-specific, genome-wide analysis of transcription and translation in complex tissues such as the brain. In addition, we have developed new technology for large-scale expression analysis of individual cells by combining cutting-edge microscopy, next-generation sequencing, and microfabrication. We apply these tools in several human disease contexts including brain tumors and other neurological disorders.

Departments and Divisions

  • Department of Biochemistry and Molecular Biophysics

Education and Training

  • PhD, 2009 Chemistry, Harvard University

NIH Grants

  • GENEEXPRESSION PROGRAMS IN MATURING DOPAMINE NEURONS: TEMPORAL REGULATION, SUBCELLULAR LOCALIZATION, AND ALTERATION BY AMPHETAMINE (Federal Gov)

    Jan 1 2019 - Dec 31 2023

    TISSUE COMPARTMENTALIZATION OF HUMAN LYMPHOCYTES (Federal Gov)

    Jun 25 2018 - May 31 2023

    IMMUNOBIOLOGY AND ALVEOLAR PHYSIOLOGY OF THE AGING LUNG (Federal Gov)

    Jan 1 2019 - Dec 31 2022

    ELUCIDATING THE DEPENDENCIES OF TUMOR INITIATING AND DRUG-RESISTANT NICHES IN HUMAN MALIGNANCIES BY GENOME-WIDE MOLECULAR PROFILING OF SINGLE CELLS (Federal Gov)

    Aug 14 2015 - Jul 31 2022

    ELUCIDATING THE DEPENDENCIES OF TUMOR INITIATING AND DRUG-RESISTANT NICHES IN HUMAN MALIGNANCIES BY GENOME-WIDE MOLECULAR PROFILING OF SINGLE CELLS (Federal Gov)

    Aug 14 2015 - Jul 31 2022

    SYSTEMATIC IDENTIFICATION AND PHARMACOLOGICAL TARGETING OF TUMOR DEPENDENCIES FOR PRECISION CANCER MEDICINE (Federal Gov)

    Jul 1 2017 - Jul 31 2022

    AN INTEGRATED MAP OF THE IMMUNE SYSTEM IN HUMANS ACROSS TISSUES AND AGES (Private)

    Jul 1 2019 - Jun 30 2022

    SINGLE CELL ANALYSIS OF THE INFILTRATIVE MARGINS OF GLIOBLASTOMA AND POST-TREATMENT RECURRENCE (Federal Gov)

    Jul 1 2017 - Jun 30 2022

    INTEGRATED IMAGING AND MOLECULAR ANALYSIS OF GLIOBLASTOMA USING SCOPE-SEQ ON THE AIR FLOW SYSTEM (Federal Gov)

    Sep 16 2019 - Jun 15 2022

    NOTCH IN ANGIOGENESIS AND VASCULAR BIOLOGY (Federal Gov)

    Jan 1 2018 - Dec 31 2021

    HUMAN ANTI-VIRAL IMMUNE RESPONSES IN TISSUES AND CIRCULATION (Federal Gov)

    Jan 1 2017 - Dec 31 2021

    NEW OPPORTUNITIES FOR MODELING DRUG RESPONSE IN SOLID TUMORS AFFORDED BY SINGLE-CELL GENOMICS (Private)

    Dec 7 2018 - Dec 6 2021

    CENTERS FOR CANCER SYSTEMS THERAPEUTICS (CAST) (Federal Gov)

    Aug 8 2016 - Jul 31 2021

    NOVEL GENOMIC AND TRANSCRIPTOMIC TOOLS TO STUDY HUMAN CONGENITAL ANOMALIES OF THE KIDNEY AND URINARY TRACT (Federal Gov)

    Sep 20 2018 - Jun 30 2021

    TOPOLOGY OF CANCER EVOLUTION AND HETEROGENEITY (Federal Gov)

    May 19 2015 - Apr 30 2021

    NOVEL GENOMIC AND TRANSCRIPTOMIC TOOLS TO STUDY HUMAN CONGENITAL ANOMALIES OF THE KIDNEY AND URINARY TRACT (Federal Gov)

    Sep 20 2018 - Jun 30 2020

    TOPOLOGY OF CANCER EVOLUTION AND HETEROGENEITY (Federal Gov)

    May 19 2015 - Apr 30 2020

    LARGE-SCALE INTEGRATION OF SINGLE CELL RNA-SEQ AND HIGH-CONTENT IMAGING FOR ANALYZING DRUG RESPONSE IN CANCER (Federal Gov)

    Apr 1 2016 - Mar 31 2020

    PATHOLOGOMICS: ESSENTIAL TREMOR IN THE BROADER CONTEXT OF NEURODEGENERATION (Federal Gov)

    Feb 1 2015 - Jan 31 2020

    FULLY INTEGRATED SINGLE CELL IMAGING AND RNA-SEQ LIBRARY PREPARATION (Federal Gov)

    Dec 15 2017 - Nov 30 2019

    THE GENETIC ORIGINS AND COMPLICATIONS OF URINARY TRACT ABNORMALITIES (Federal Gov)

    Sep 24 2014 - Sep 24 2019

    THE GENETIC ORIGINS AND COMPLICATIONS OF URINARY TRACT ABNORMALITIES (Federal Gov)

    Sep 24 2014 - Jul 31 2019

    LARGE-SCALE INTEGRATION OF SINGLE CELL RNA-SEQ AND HIGH-CONTENT IMAGING FOR ANALYZING DRUG RESPONSE IN CANCER (Federal Gov)

    Apr 1 2016 - Mar 31 2019

    REDEFINING DM BY AGNOSTIC KIDNEY INTERROGATION: A PILOT GRANT IN CONFIRMATION OF SN-RNASEQ TECHNOLOGY (Federal Gov)

    Nov 1 2017 - Oct 31 2018

    MOLECULAR MECHANISMS UNDERLYING THE EPILEPTOGENESIS AND SEIZURE PROGRESSION IN TUBEROUS SCLEROSIS COMPLEX 1 DEFICIENT MOUSE MODELS (Federal Gov)

    Sep 15 2015 - Sep 14 2018

    COMPARATIVE STUDIES OF LARGE-SCALE SINGLE CELL SEQUENCING TECHNOLOGIES IN COMPLEX TISSUES WITH INTEGRATED ON-CHIP IMAGING (Private)

    Sep 1 2017 - Aug 31 2018

    TARGETING KIF11 TO TREAT GLIOBLASTOMA INVASION AND PROLIFERATION (Federal Gov)

    Jul 1 2017 - Jun 30 2018

    A MICROFLUIDIC SYSTEM FOR IMAGE-GUIDED RNA-SEQ OF SINGLE CELLS IN GLIOBLASTOMA (Federal Gov)

    Sep 30 2012 - Aug 31 2017

    A MICROFLUIDIC SYSTEM FOR IMAGE-GUIDED RNA-SEQ OF SINGLE CELLS IN GLIOBLASTOMA (Federal Gov)

    Sep 30 2012 - Aug 31 2017

    A MICROFLUIDIC SYSTEM FOR IMAGE-GUIDED RNA-SEQ OF SINGLE CELLS IN GLIOBLASTOMA (Federal Gov)

    Sep 30 2012 - Aug 31 2017

    NEURONAL TRANSLATION IN TSC2+/-AND FMR1-/Y MUTANT ASD MOUSE MODELS (Private)

    Jul 1 2015 - Jun 30 2017

    THE ROLE OF PHOSPHOR-RPS6 AND TRANSLATIONAL REGULATION IN GLIOMA (Federal Gov)

    Jul 1 2014 - Jun 30 2017

    THE ROLE OF PHOSPHOR-RPS6 AND TRANSLATIONAL REGULATION IN GLIOMA (Federal Gov)

    Jul 1 2014 - Jun 30 2017

    MULTIPLEX RNA IMAGING IN SINGLE CELLS BY SUPERRESOLUTION MICROSCOPY AND BARCODE FISH (Federal Gov)

    Jul 1 2016 - Jun 30 2017

    IDENTIFYING NOVEL GILOMA THERAPEUTIC TARGETS USING AN ECOSYSTEMS APPROACH (Federal Gov)

    Sep 1 2015 - Aug 31 2016

    SINGLE CELL STUDIES OF LINEAGE SPECIFIC EXPRESSION OF THE PROTOCADHERIN GENE CLUSTER (Federal Gov)

    Jul 1 2014 - Jun 30 2016

    SINGLE CELL STUDIES OF LINEAGE SPECIFIC EXPRESSION OF THE PROTOCADHERIN GENE CLUSTER (Federal Gov)

    Jul 1 2014 - Jun 30 2016

    GENE EXPRESSION CHANGES IN STRIATAL CHOLINERGIC INTERNEURONS ASSOCIATED WITH L-DOPA-INDUCED DYSKINESIA IN PD. (Private)

    Aug 7 2014 - Aug 6 2015

    MULTIPLEXED, SINGLE MOLECULE PROTEIN IDENTIFICATION FOR SINGLE CELL PROTEOMICS (Federal Gov)

    Sep 30 2012 - Aug 31 2014

    MULTIPLEXED, SINGLE MOLECULE PROTEIN IDENTIFICATION FOR SINGLE CELL PROTEOMICS (Federal Gov)

    Sep 30 2012 - Aug 31 2014

    CELL TYPE-SPECIFIC PROFILING FOR AUTISM SPECTRUM DISORDERS (Private)

    Dec 1 2012 - Nov 30 2013