Iok In Christine Chio, PhD

Academic Appointments

  • Assistant Professor of Genetics and Development (in the Institute for Cancer Genetics)
Iok In Christine Chio, PhD

Email: ic2445@cumc.columbia.edu

Christine Chio studies Pancreatic ductal adenocarcinoma (PDAC) that represents the third leading cause of cancer death in the United States. Lethality of PDA owes largely to the advanced disease stage at the time of diagnosis and to its profound resistance to existing therapies. Targeted therapy is a cornerstone of precision medicine, and is currently the focus of much anticancer drug development. However, in the context of pancreatic cancer, no chemical inhibitors exist for the most common KRAS mutations (G12D, G12V) even though it is well established that the oncogenic KRAS promotes drug resistance. Thus, a detailed understanding of the role of specific genetic lesions and their signaling surrogates in the initiation and progression of PDA is critical to improving treatment efficacy and patient outcome for this disease. Using genetically engineered mouse models and ex vivo culture systems, the Chio lab seeks to understand the basic mechanisms underlying PDAC biology such that vulnerabilities can be identified and tested for therapeutic intervention. For more information please visit chiolab.com.

Departments and Divisions

  • Department of Genetics & Development

Lab Locations

  • Irving Cancer Research Center

    1130 St. Nicholas Avenue
    Room 505
    New York, NY 10032
    Phone:
    (212) 851-4967
    Lab Phone:
    (212) 851-4966
    Email:
    ic2445@cumc.columbia.edu

Contact Info

  • (212) 851-4967

Past Positions

Research experience

11/17-Present: Assistant professor at Columbia University. Department of Genetics and Development. Institute of Cancer Genetics.

11/12-10/17: Postdoctoral research fellow in Dr David Tuveson’s laboratory: Project: Analysis of oxidative stress and Nrf2 in pancreatic cancer development

09/06-11/12: PhD research in Dr Tak Wah Mak’s laboratory: Project: Analysis of the TRADD adaptor protein in TNFR1 and other signaling pathways.

09/05-09/06: Independent research course. Project: Structural and functional analysis of RHAMM, a microtubule associated protein, in cell division.

Summers of 05 and 06: Summer research student in the lab of Dr. Andrew Wilde (Dept of Medical Genetics, U of Toronto). Participation in research projects designed to understand the molecular mechanisms of chromosome segregation and cell division.

Presentations

Poster and oral presentations:

02/2018. Invited speaker of Cancer Colloquium on NRF2. St. Andrews, Scotland, UK.

06/2017. Invited speaker of 2nd Asia Pacific Nano Biotechnology Summit” at Holiday Inn Atrium, Singapore

05/17: Invited speaker of 2017 AGCTS-ASSCR Conference as a funded Plenary Speaker (Sydney, Australia).

1/17: Invited speaker of the IMP-IMBA-BI Meeting on Advances in modelling development and disease in vitro (18-20 January 2017, Vienna Austria). Title of presenation: Organoids to study pancreatic cancer.

10/16: Conference oral presentation: AACR: Translational Control of Cancer (San Francisco, California). Title of presentation: NRF2 promotes mRNA translation in pancreatic cancer.

10/16: Invited speaker of Plenary session for EMBO EMBL Symposium on Organoids: Modelling Organ Development and Disease in 3D Culture, Heidelberg, Germany. Title of presentation: Organoid models of Pancreatic Cancer Biology and Therapy

09/16: Invited speaker of Banbury meeting on ROS and Chemotherapy. Title of presentation: NRF2 promotes mRNA translation in pancreatic cancer.

Poster presenation at 31st Aspen Cancer Conference (Aspen, Colorado). Poster title: NRF2 promotes tumor maintenance through modulating mRNA translation in pancreatic cancer.

06/16: Poster presentation at the Cold Spring Harbor Laboratory 81st Symposium of Quantitative Biology. Poster title: NRF2 mediates redox-dependent mRNA translation and tumor maintenance in pancreatic cancer

05/16: Conference oral presentation. The Special AACR conference on Pancreatic Cancer (Orlando, Florida). Title of presentation: NRF2 promotes mRNA translation in pancreatic cancer.

04/15: Invited speaker of CSHL in-house symposium. Title of presenation Redox regulation in pancreatic cancer

08/14: Poster presentation at Models and Mechanism of Cancer conference, CSHL. Poster title: Investigating the role of Nrf2 in pancreatic cancer development

10/14: Poster presentation at Damon Runyon Fellow’s retreat. Poster Title: Redox regulation in pancreatic cancer

04/09: Conference oral presentation. Plenary session of the 12th International TNF conference: Madrid, Spain. Title of presentation: Beyond TNFR1 signaling, the multi-functionality of TRADD

11/08: Poster presentation at the Campbell Family Institute of Cancer Research Annual Retreat. Poster title: Analysis of the multi-functionality of the TRADD adaptor protein.

Committees / Societies / Memberships

Present: Member of American Association of Cancer Research

2003-Present: Member of Golden Key International Honour Society

10/2013- Present: Damon Runyon Research Fellow

4/2015-Present: Member of American Association for Cancer Research

2/2017-Present: Editorial board member of “Gastroenterology and Liver Clinical and Medical Issues”

NIH Grants

  • NRF2-DEPENDENT REDOX SIGNALING IN PANCREATIC CANCER (Federal Gov)

    Mar 4 2020 - Feb 28 2025

    TARGETING REDOX STATUS AND MRNA TRANSLATION IN PANCREATIC CANCER (Private)

    Jul 1 2018 - Jun 30 2021

    CLINICAL TRANSLATION OF REGULATORY NETWORK-BASED PRECISION MEDICINE FOR PANCREATIC CANCER (Private)

    Apr 1 2018 - Mar 31 2021

    TARGETING REDOX-DEPENDENT PROTEIN SYNTHESIS IN KRAS-DRIVEN CANCERS (Private)

    Nov 1 2018 - Nov 1 2020

    METABOLIC PROFILING TO IDENTIFY KEY REGULATORY EVENTS THAT DRIVE PANCREATIC TUMORIGENESIS AND METASTATIC DISSEMINATION (Private)

    Jun 1 2019 - May 31 2020

Lab Members

Postdoctoral fellows:
1. Marina M. Ayres Pereira- mma2246@cumc.columbia.edu
2. Ipsita Pal- ip2326@cumc.columbia.edu

Graduate Student:
1. Michael B. Mendelsohn-mbm2220@cumc.columbia.edu

Undergraduate project student
1. Jordan Jordan Lu - jjl2246@columbia.edu

Technician
1. Belen Sundberg -bs3281@cumc.columbia.edu

 

Publications

eIF4A-dependent translational control of central carbon metabolism in pancreatic ductal adenocarcinoma. Nature Communications.  Chan KM, Robert F, Oertlin C, Kapeller-Libermann, D, Avizonis D, Park J, Schoepfer C, Da Silva B, Yao M, Gorton F, Thomas C, Brown L, Porco J, Doubrovin M, Pollak M, Larsson O, Pelletier J, Chio II.  2019; 10, 5151.

Metastasis in Pancreatic Cancer: advances in the field and methodologies.   Ayres Pereira M, Chio II.  Genes. 2019; 11 (1), 6

PDA Got SERious Nerves.  Yang X, Chio IIC. Trends Cancer. 2021.
PMID: 33341431, DOI: 10.1016/j.trecan.2020.12.004

Metastasis in Pancreatic Ductal Adenocarcinoma: Current Standing and Methodologies
Ayres Pereira M, Chio IIC. Genes (Basel). 2019.
PMID: 31861620, DOI: 10.3390/genes11010006

Bioactivation of Napabucasin Triggers Reactive Oxygen Species-Mediated Cancer Cell Death
Froeling FEM, Swamynathan MM, Deschênes A, Chio IIC, Brosnan E, Yao MA, Alagesan P, Lucito M, Li J, Chang AY, Trotman LC, Belleau P, Park Y, Rogoff HA, Watson JD, Tuveson DA
Clin Cancer Res. 2019.
PMID: 31527169, DOI: 10.1158/1078-0432.CCR-19-0302

Identification of Resistance Pathways Specific to Malignancy Using Organoid Models of Pancreatic Cancer.  Ponz-Sarvise M, Corbo V, Tiriac H, Engle DD, Frese KK, Oni TE, Hwang CI, Öhlund D, Chio IIC, Baker LA, Filippini D, Wright K, Bapiro TE, Huang P, Smith P, Yu KH, Jodrell DI, Park Y, Tuveson DA
Clin Cancer Res. 2019.
PMID: 31492749, DOI: 10.1158/1078-0432.CCR-19-1398

eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma
Chan K, Robert F, Oertlin C, Kapeller-Libermann D, Avizonis D, Gutierrez J, Handly-Santana A, Doubrovin M, Park J, Schoepfer C, Da Silva B, Yao M, Gorton F, Shi J, Thomas CJ, Brown LE, Porco JA, Pollak M, Larsson O, Pelletier J, Chio IIC.  Nat Commun. 2019.
PMID: 31723131, DOI: 10.1038/s41467-019-13086-5

A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product
Liberti MV, Dai Z, Wardell SE, Baccile JA, Liu X, Gao X, Baldi R, Mehrmohamadi M, Johnson MO, Madhukar NS, Shestov AA, Chio IIC, Elemento O, Rathmell JC, Schroeder FC, McDonnell DP, Locasale JW
Cell Metab. 2017.
PMID: 28918937, DOI: 10.1016/j.cmet.2017.08.017

ROS in Cancer: The Burning Question
Chio IIC, Tuveson DA.  Trends Mol Med. 2017.
PMID: 28427863, DOI: 10.1016/j.molmed.2017.03.004

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
Öhlund D, Handly-Santana A, Biffi G, Elyada E, Almeida AS, Ponz-Sarvise M, Corbo V, Oni TE, Hearn SA, Lee EJ, Chio II, Hwang CI, Tiriac H, Baker LA, Engle DD, Feig C, Kultti A, Egeblad M, Fearon DT, Crawford JM, Clevers H, Park Y, Tuveson DA.  J Exp Med. 2017.
PMID: 28232471, DOI: 10.1084/jem.20162024

NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer
Chio IIC, Jafarnejad SM, Ponz-Sarvise M, Park Y, Rivera K, Palm W, Wilson J, Sangar V, Hao Y, Öhlund D, Wright K, Filippini D, Lee EJ, Da Silva B, Schoepfer C, Wilkinson JE, Buscaglia JM, DeNicola GM, Tiriac H, Hammell M, Crawford HC, Schmidt EE, Thompson CB, Pappin DJ, Sonenberg N, Tuveson DA
Cell. 2016.
PMID: 27477511, DOI: 10.1016/j.cell.2016.06.056

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH
Yun J, Mullarky E, Lu C, Bosch KN, Kavalier A, Rivera K, Roper J, Chio II, Giannopoulou EG, Rago C, Muley A, Asara JM, Paik J, Elemento O, Chen Z, Pappin DJ, Dow LE, Papadopoulos N, Gross SS, Cantley LC
Science. 2015.
PMID: 26541605, DOI: 10.1126/science.aaa5004

Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio.  Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF, Brenner D, Harris IS, Chio II, Afzal S, Cairns RA, Cescon DW, Elford AR, Ye J, Lang PA, Li WY, Wakeham A, Duncan GS, Haight J, You-Ten A, Snow B, Yamamoto K, Ohashi PS, Mak TW.  Cell Death Differ. 2015.
PMID: 25882048, DOI: 10.1038/cdd.2015.38

Organoid models of human and mouse ductal pancreatic cancer
Boj SF, Hwang CI, Baker LA, Chio II, Engle DD, Corbo V, Jager M, Ponz-Sarvise M, Tiriac H, Spector MS, Gracanin A, Oni T, Yu KH, van Boxtel R, Huch M, Rivera KD, Wilson JP, Feigin ME, Öhlund D, Handly-Santana A, Ardito-Abraham CM, Ludwig M, Elyada E, Alagesan B, Biffi G, Yordanov GN, Delcuze B, Creighton B, Wright K, Park Y, Morsink FH, Molenaar IQ, Borel Rinkes IH, Cuppen E, Hao Y, Jin Y, Nijman IJ, Iacobuzio-Donahue C, Leach SD, Pappin DJ, Hammell M, Klimstra DS, Basturk O, Hruban RH, Offerhaus GJ, Vries RG, Clevers H, Tuveson DA
Cell. 2015.
PMID: 25557080, DOI: 10.1016/j.cell.2014.12.021

D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function
Sasaki M, Knobbe CB, Itsumi M, Elia AJ, Harris IS, Chio II, Cairns RA, McCracken S, Wakeham A, Haight J, Ten AY, Snow B, Ueda T, Inoue S, Yamamoto K, Ko M, Rao A, Yen KE, Su SM, Mak TW
Genes Dev. 2012.
PMID: 22925884, DOI: 10.1101/gad.198200.112

TRADD contributes to tumour suppression by regulating ULF-dependent p19Arf ubiquitylation
Chio II, Sasaki M, Ghazarian D, Moreno J, Done S, Ueda T, Inoue S, Chang YL, Chen NJ, Mak TW
Nat Cell Biol. 2012.
PMID: 22561347, DOI: 10.1038/ncb2496

Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors
Chen NJ, Chio II, Lin WJ, Duncan G, Chau H, Katz D, Huang HL, Pike KA, Hao Z, Su YW, Yamamoto K, de Pooter RF, Zúñiga-Pflücker JC, Wakeham A, Yeh WC, Mak TW.  Proc Natl Acad Sci USA. 2008.
PMID: 18719121, DOI: 10.1073/pnas.0806585105

For a complete list of publications, please visit PubMed.gov