Academic Appointments
- Professor of Genetics and Development (in Neuroscience)
Current Administrative Positions
- Principal Investigator at Columbia's Zuckerman Institute
Zuckerman Institute: https://zuckermaninstitute.columbia.edu/gary-struhl-phd
Struhl Lab: https://struhl-lab.zuckermaninstitute.columbia.edu/
During development, cells are programmed to generate and interpret spatial information so that every cell within a population knows where it is and what to do as a consequence. Dr. Struhl's work uses genetical and molecular approaches in Drosophila to address the fundamental questions (i) what is spatial information?, (ii) how is it generated?, and (iii) how is it interpreted? His work has led to discoveries about the nature and mode action of spatial determinants controlling cell and body patterns, tissue growth and planar cell polarity. These include (i) the Polycomb and HOX “selectors” in specifying body segments; (ii) the transcription and translation factors Bicoid, Caudal, Hunchback and Nanos in organizing global body pattern, (iii) secreted factors of the Hedgehog, Wnt, and BMP/TGFb superfamilies as the first, intercellular gradient morphogens, (iv) Delta/Notch signaling in cell-fate specification, and (v) the serpentine receptors Frizzled and Starry night, and the atypical cadherins Dachsous and Fat, in planar cell polarity.
Zuckerman Institute: https://zuckermaninstitute.columbia.edu/gary-struhl-phd
Struhl Lab: https://struhl-lab.zuckermaninstitute.columbia.edu/
Departments and Divisions
- Department of Genetics & Development
Links
Lab Locations
Jerome L. Greene Science Center
3227 Broadway
L9-035
New York, NY 10027- Phone:
- (212) 853-3575
- Email:
- gs20@columbia.edu
Honors and Awards
American Academy of Arts and Sciences Member (2005)
National Academy of Sciences Member (2008)
Research Interests
- Cell-cell signaling
- Cell patterning
- Organ growth
Grants
THE MECHANISM OF NOTCH ACTIVATION BY EPSIN-DEPENDENT LIGAND ENDYCYTOSIS IN DROSOPHILA
5RO1GM109183-04
Project Dates: Sep 1 2014 to May 31 2018
CONTROL OF DROSOPHILA WING GROWTH BY MORPHOGEN
1R35GM127141
Project Dates: May 1, 2018 to April 31 2023
NIH Grants
CONTROL OF DROSOPHILIA WING GROWTH BY MORPHOGEN (Federal Gov)
Sep 16 2014 - Jul 31 2018
CONTROL OF DROSOPHILIA WING GROWTH BY MORPHOGEN (Federal Gov)
Sep 16 2014 - Jul 31 2018
CONTROL OF DROSOPHILIA WING GROWTH BY MORPHOGEN (Federal Gov)
Sep 16 2014 - Jul 31 2018
MECHANISM OF NOTCH ACTIVATION BY EPSIN-DEPENDENT LIGAND ENDOCYTOSIS IN DROSOPHILA (Federal Gov)
Sep 1 2014 - May 31 2018
MECHANISM OF NOTCH ACTIVATION BY EPSIN-DEPENDENT LIGAND ENDOCYTOSIS IN DROSOPHILA (Federal Gov)
Sep 1 2014 - May 31 2018
CONTROLOF TISSUE MASS DURING AGING BY MORPHOGENS, STEROID HORMONES AND THE HIPPO TUMOR SUPPRESSOR PATHWAY (Private)
Oct 1 2011 - Sep 30 2015
THE ROLE OF NOTCH IN BEHAVIORAL PLASTICITY (Federal Gov)
Jan 1 2011 - Jun 30 2015
STUDIES IN ALZHEIMER DISEASES (Private)
Dec 1 2000 - Dec 31 2014
PLANER CELL POLARITY PROTEIN ACTIVITY AND FUNCTION IN DEVELO PING EPITHELIA (Private)
May 1 2009 - Apr 30 2012
Publications
- Evolutionary plasticity in the requirement for force exerted by ligand endocytosis to activate C. elegans Notch proteins. Langridge PD et al. Curr. Biol. 2022 Mar 23
- A unified mechanism for mechanism for the control of Drosophila wing growth by the morphogens Decapentaplegic and Wingless. Zecca M, Struhl G. PLoS Biol. 2021 Mar 3
- Control of Drosophila wing size by morphogen range and hormonal gating. Parker, J, Struhl, G. Proc. Natn. Acad. Sci. U.S.A. 2020 Dec 15
- Epsin-dependent ligand endocytosis activates Notch by force. Langridge PD, Struhl G. Cell.2017 Nov 30
- Causal role for inheritance of H3K27me3 in maintaining the OFF state of a Drosophila HOX gene. Coleman RT, Struhl G. Science.2017 Mar 16
- Fat/Dachsous Signaling Promotes Drosophila Wing Growth by Regulating the Conformational State of the NDR Kinase Warts. Vrabioiu AM, Struhl G. Dev Cell.2015 Dec 21
- A feed-forward circuit linking wingless, fat-dachsous signaling, and the warts-hippo pathway to Drosophila wing growth. Zecca M, Struhl G. PLoS Biol.2010 Jun 1
For a complete list of publications, please visit PubMed.gov