Darrell J. Yamashiro, MD

Academic Appointments

  • Robert and Ellen Kapito Associate Professor of Pediatrics at the Columbia University Medical Center

Current Administrative Positions

  • Chief, Division of Hematology, Oncology, and Stem Cell Transplantation
Darrell J. Yamashiro, MD

I am a pediatric oncologist who specializes in caring for children with solid tumors, especially neuroblastoma, Wilms' and other kidney tumors, and liver tumors such hepatoblastoma and hepatocellular carcinoma. I serve as chief of the Division of Hematology, Oncology and Stem Cell Transplantation at Columbia University Irving Medical Center and NewYork-Presbyterian Morgan Stanley Children's Hospital.

I treat children of all ages, from infants to young adults. Some of the cancers I treat are rare (liver tumors account for one to two percent of childhood cancers), but they can be very complex and require a multidisciplinary approach so patients have the best outcomes. I enjoy working as part of a team of physicians, nurse practitioners, nurses, social workers, child life specialists, and other dedicated professionals who care deeply about our patients and provide care with compassion and comfort.

I also conduct basic science research. The latest advances in tumor genetics and the design of innovative therapies make this a very exciting time for cancer research. My team and I have done extensive research on the genetics of hepatoblastoma. We have developed mouse models of this disease and are entering a new phase where we are offering a personalized/precision medicine approach to children with this disease. We are also identifying novel genes that specifically target neuroblastoma—information that may be used to create targeted therapies.

Departments and Divisions

  • Department of Pediatrics
    Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation
  • Department of Pathology & Cell Biology

Board Certifications

  • Pediatric Hematology-Oncology
  • Pediatrics

Areas of Expertise

  • Cancer Care
  • Angiogenesis
  • Hepatoblastoma
  • Neuroblastoma
  • Pediatric Liver Cancer
  • Pediatric Solid Tumors
  • Wilm's Tumor

Education and Training

  • Internship: Children's Hospital of Philadelphia
  • Residency: Children's Hospital of Philadelphia
  • Fellowship: Children's Hospital of Philadelphia

Locations

  • CUIMC/Herbert Irving Pavilion

    161 Fort Washington Avenue
    New York, NY 10032
    For new and current patient appointments, call:
    (212) 305-9770
    Fax:
    (212) 305-5848

Centers / Institutes / Programs

  • Herbert Irving Comprehensive Cancer Center

Provider Affiliations

  • NewYork-Presbyterian / Columbia University Irving Medical Center
  • NewYork-Presbyterian Morgan Stanley Children's Hospital

Insurance Programs

Please contact the provider's office directly to verify that your particular insurance is accepted.

  • AETNA [Aetna Signature Administrators, EPO, HMO, Medicare Managed Care, NYP Employee Plan, NY Signature, POS, PPO, Student Health]
  • Affinity Health Plan [Essential Plan, Medicaid Managed Care]
  • Amida Care [Special Needs]
  • CIGNA [EPO, Great West (National), HMO, POS, PPO]
  • Emblem/GHI [Medicare Managed Care, PPO]
  • Emblem/HIP [ConnectiCare, EPO, Essential Plan, HMO, Medicaid Managed Care, Medicare Managed Care, POS, PPO, Select Care (Exchange), Vytra]
  • Empire Blue Cross/Blue Shield [EPO, HMO, Medicare Managed Care, PPO]
  • Empire Blue Cross Blue Shield HealthPlus [Child/Family Health Plus, Essential Plan, Medicaid Managed Care]
  • Fidelis Care [Child/Family Health Plus, Essential Plan, Medicaid Managed Care, Medicare Managed Care]
  • Healthfirst [Child/Family Health Plus, Leaf (Exchange), Medicaid Managed Care, Medicare Managed Care]
  • Local 1199 [Local 1199]
  • MagnaCare (National) [MagnaCare]
  • Medicare [Railroad, Traditional Medicare]
  • Multiplan [Multiplan]
  • MVP Health Care [Child/Family Health Plus, Essential Plan, HMO, Medicaid Managed Care]
  • Oxford Health Plans [Freedom, Liberty]
  • UnitedHealthcare [Compass (Exchange), Empire Plan, HMO, Medicaid (Community Plan), Medicare Managed Care, POS, PPO]
  • VNSNY CHOICE [Medicare Managed Care, SelectHealth, Special Needs]
  • WellCare [Medicaid Managed Care, Medicare Managed Care]

This provider sees pediatric patients

This provider accepts new patients

Appointment Phone Number: (212) 305-9770

NIH Grants

  • QUANTUM COLLABORATION AWARD (Private)

    Aug 15 2018 - Dec 15 2023

    COLUMBIA UNIVERSITY DEVELOPMENTAL THERAPEUTICS PROGRAM: STRIVING FOR EXCELLENCE (Private)

    Jan 1 2014 - Dec 31 2018

    PRECISION MEDICINE PROGRAM FOR CHILDREN WITH HIGH-RISK CANCERS (Private)

    Jan 1 2016 - Sep 30 2018

    SOHN COLLABORATIVE FOR PEDIATRIC CANCER RESEARCH (Private)

    Apr 22 2014 - Dec 31 2016

    PEDIATRIC ONCOLOGY STUDENT TRAINING (POST) PROGRAM (Private)

    Apr 1 2015 - Mar 31 2016

    IDENTIFICATION OF TFAP4 (TRANSCRIPTION FACTOR AP-4/ACTIVATING ENHANCER BINDING PROTEIN) AS A POTENTIAL MASTER REGULATOR/SYNTHETIC LETHAL GENE OF MYCN AMPLIFIED NEUROBLASTOMA (Private)

    Jul 1 2013 - Jul 1 2015

    PEDIATRIC CANCER FOUNDATION DEVELOPMENTAL THERAPEUTICS PROGRAM (PCFDTP) (Private)

    Jul 1 2005 - Jun 30 2015

    VEGF BLOCKADE AND ALTERNATIVE ANGIOGENIC PATHWAYS IN NEUROBLASTOMA (Federal Gov)

    Apr 10 2008 - Jan 31 2014

    USING CONTRAST ENHANCED ULTRASOUND TO ASSESS THE EFFICACY OF ADT INHIBITION AS A RADIOSENSITIZER IN EXPERIMENTAL NEUROBLASTOMA (Private)

    May 1 2013 - Aug 31 2013

    NOVEL MICROBUBBLE-BASED GENE DELIVERY VEHICLES TARGETING SOL ID TUMORS (Private)

    Jul 1 2009 - Jan 31 2011

    THE ROLE OF NOTCH SIGNALING IN NEUROBLASTOMA ANGIOGENESIS (Private)

    Jul 1 2007 - Jun 30 2010

Publications

Boboila S, Lopez G, Yu J, Banerjee D, Kadenhe-Chiweshe A, Connolly EP, Kandel JJ, Rajbhandari P, Silva JM, **Califano A, **Yamashiro DJ. Transcription factor activating protein 4 is synthetically lethal and a master regulator of MYCN-amplified neuroblastoma. Oncogene. 2018. Epub 2018/06/09. doi: 10.1038/s41388-018-0326-9. PubMed PMID: 29880876.

Tavana O, Li D, Dai C, Lopez G, Banerjee D, Kon N, Chen C, Califano A, Yamashiro DJ, Sun H, Gu W. HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma. Nat Med. 2016. doi: 10.1038/nm.4180. PubMed PMID: 27618649.

Oberg JA, Glade Bender JL, Sulis ML, Pendrick D, Sireci AN, Hsiao SJ, Turk AT, Dela Cruz FS, Hibshoosh H, Remotti H, Zylber RJ, Pang J, Diolaiti D, Koval C, Andrews SJ, Garvin JH, Yamashiro DJ, Chung WK, Emerson SG, Nagy PL, Mansukhani MM, Kung AL. Implementation of next generation sequencing into pediatric hematology-oncology practice: moving beyond actionable alterations. Genome Med. 2016;8(1):133. doi: 10.1186/s13073-016-0389-6. PubMed PMID: 28007021; PMCID: PMC5180407.

Dela Cruz FS, Diolaiti D, Turk AT, Rainey AR, Ambesi-Impiombato A, Andrews SJ, Mansukhani MM, Nagy PL, Alvarez MJ, Califano A, Forouhar F, Modzelewski B, Mitchell CM, Yamashiro DJ, Marks LJ, Bender JL, Kung AL. A case study of an integrative genomic and experimental therapeutic approach for rare tumors: identification of vulnerabilities in a pediatric poorly differentiated carcinoma. Genome Med. 2016;8(1):116. doi: 10.1186/s13073-016-0366-0. PubMed PMID: 27799065.

Jani A, Shaikh F, Barton S, Willis C, Banerjee D, Mitchell J, Hernandez SL, Hei T, Kadenhe-Chiweshe A, **Yamashiro DJ, **Connolly EP. High-Dose, Single-Fraction Irradiation Rapidly Reduces Tumor Vasculature and Perfusion in a Xenograft Model of Neuroblastoma. Int J Radiat Oncol Biol Phys. 2016;94(5):1173-80. doi: 10.1016/j.ijrobp.2015.12.367. PubMed PMID: 26907918.

Banerjee D, Hernandez SL, Garcia A, Kangsamaksin T, Sbiroli E, Andrews J, Forrester LA, Wei N, Kadenhe-Chiweshe A, Shawber CJ, Kitajewski JK, **Kandel JJ, **Yamashiro DJ. Notch suppresses angiogenesis and progression of hepatic metastases. Cancer Res. 2015;75(8):1592-1602. PMID: 25744722; PMCID: PMCPMC4401639.

For a complete list of publications, please visit PubMed.gov