Wang Laboratory

Research Overview

The Wang Lab's research focuses on understanding how cell identity is established, maintained, and altered during mammalian (both mouse and human) development. Specifically, we study the molecular control of stemness underlying pluripotency, reprogramming, and tumorigenesis. We employ both genomic and proteomic approaches as well as mouse models to identify and study novel transcription factors and epigenetic regulators that control stemness in pluripotent/totipotent stem cells and cancers.

Current projects include:

  • Dissect molecular mechanisms of naïve and primed pluripotency in mouse and human systems.
  • Understand molecular control of totipotency and expanded pluripotency.
  • Study RNA binding proteins in pluripotency and development control.
  • Understand pluripotency regulators as stemness factors in cancers.
  • Study transcriptional and epigenetic control of early development.

Jianlong Wang, PHD
Professor of Medicine
Columbia Center for Human Development (CCHD)
Herbert Irving Comprehensive Cancer Center (HICCC)
Columbia Center for Stem Cell Initiative (CSCI)

For more information, please visit The Wang Laboratory