Sanja Jelic, M.D.
Associate Professor of Medicine at Columbia University Medical Center
Bio
Education and Training
Honors and Awards
- 2007-2010 American Lung Association Research Grant
- 2006 American Thoracic Society: Highlighted Research
- 2006 American Thoracic Society Travel Award
- 2005-2010 Irving Scholar
- 2003-2005 Sleep Medicine Education and Research Foundation, Young Investigator Research Award
- 2002 American Federation for Medical Research Travel Award
Clinical
To initiate a transfer request, physicians should call 1-800-NYP-STAT which is available 24 hours a day, 7 days a week.
Specialties
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Pulmonary Disease Medicine
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Critical Care Medicine
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Sleep Medicine
Clinical Expertise
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Pulmonary Disease Medicine
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Critical Care Medicine
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Sleep Medicine
Clinical Centers
Board Certifications
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Internal Medicine
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Pulmonary Disease
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Critical Care Medicine
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Sleep Medicine
Research
Jelic Laboratory
P&S 8 Rm 512
630 W. 168th Street
New York, NY 10032
P: (212) 342-0256
Research Interest
Vascular complications of sleep apnea and sleep deprivation.
Funding
American Heart Association 16SFRN29050000 (PI: Jelic) 2016 - 2020
AHA Strategically Focused Research Network
Title: The Effects of Sleep Restriction on Endothelial Activation in pre- and post-menopausal women
The major goal of this project is to investigate molecular mechanisms of endothelial dysfunction in sleep
restriction, an emerging cardiovascular risk factor.
R56HL106041 (PI: Jelic) 2016 - 2017
NIH/NHLBI
Title: Vascular Endothelial Activation in Sleep Apnea
This project will determine whether intermittent hypoxia-induced cholesterol accumulation in endothelial cells alters complement inhibition leading to endothelial dysfunction and increased vascular risk in obstructive sleep apnea. .
2 R01 HL106041-06A1 (PI: Jelic) 2017 - 2021
NIH/NHLBI
Title: Vascular Endothelial Activation in Sleep Apnea
The goals of this project are: 1) To determine whether reduced complement inhibition promotes endothelial dysfunction in OSA and whether CPAP reverses these changes, 2) To determine whether reduced complement inhibition is mediated by cholesterol accumulation in ECs in OSA and whether CPAP reverses these changes, and 3) To determine whether statins prevent endothelial dysfunction in OSA by preserving complement inhibition using randomized design. Using an innovative approach to characterize human vascular endothelium, the proposed studies may advance our understanding of vascular dysfunction in OSA and provide the basis for clinical trials of novel therapeutic strategies, such as addition of statins to the standard CPAP therapy, for preventing and/or reversing vascular risk in OSA.
Selected Publications
1. Jelic S, Padeletti M, Canfield S, Higgins C, Kawut SM, Onat D, Colombo P, Basner RC, Factor P, LeJemtel T. Inflammation, Oxidative Stress and Repair Capacity of the Vascular Endothelium in Obstructive Sleep Apnea. Circulation 2008;117:2270-8.
2. Jelic S, Lederer D, Adams T, Padeletti M, Colombo P, Factor P, Le Jemtel T. Vascular Inflammation in Obesity and Sleep Apnea. Circulation 2010;121:1014-21.
3. Marin JM, Alvar A, Villar I, Forner M, Nieto D, Carrizo SJ, Barbe F, Vicente E, Wei Y, Nieto FJ, Jelic S. Association between Treated and Untreated Obstructive Sleep Apnea and Risk of Hypertension. JAMA. 2012;307:2169-76.
4. Emin M, Wang G, Castagna F, Rodriguez-Lopez J, Wahab R, Wang J, Adams T, Wei Y, Jelic S. Increased Internalization of Complement Inhibitor CD59 May Contribute to Endothelial Inflammation in Obstructive Sleep Apnea. Sci Transl Med. 2016;8:320ra1. doi: 10.1126/scitranslmed.aad0634. PMID:26738794
622 West 168 Street | PH 8 East, Room 101
