Susan F. Steinberg, MD

Academic Appointments

  • Professor of Molecular Pharmacology and Therapeutics
Susan F. Steinberg, MD

The studies in my laboratory aim to identify the mechanisms that underlie the physiologically important changes in cardiomyocyte adrenergic receptor responsiveness that accompany normal cardiac development, that influence the evolution of heart failure, or that contribute to cardiac injury in the setting of ischemia-reperfusion injury and oxidative stress. Our studies take advantage of a wide range of reductionist molecular and cell biological approaches in both cell culture and in vitro models to study the expression and subcellular localization of adrenergic receptor subtypes, to identify the adrenergic receptor binding partners and effectors that dictate signaling specificity in cardiomyocytes, and to understand the molecular basis for catecholamine-dependent cardiomyocyte remodeling. One area of particular interest has been the stimulus- (in some cases redox-) dependent post-translational modifications on signaling kinases such as protein kinase C and protein kinase D that alter their enzymology. We also have identified post-translational processing (involving an O-glycan-regulated proteolytic cleavage) of the beta1-adrenergic receptor N-terminus as a mechanism that calibrates signaling output to downstream effector responses. In both cases, these studies identify novel molecular determinants that can serve as druggable targets.

Departments and Divisions

  • Department of Molecular Pharmacology and Therapeutics

Education and Training

  • BS, 1972 Biology, Massachusetts Institute of Technology
  • MD, 1976 Medicine, Harvard Medical School
  • Internship: 1977 Columbia Presbyterian Medical Center, NY
  • Residency: 1979 Columbia Presbyterian Medical Center, NY
  • Fellowship: 1982 Columbia Presbyterian Medical Center, NY

Committees / Societies / Memberships

MEMBERSHIPS IN PROFESSIONAL SOCIETIES:

Diplomat, Internal Medicine, American Board of Internal Medicine

Diplomat, Endocrinology & Metabolic Diseases, American Board of Internal Medicine

American Federation for Clinical Research

American Society for Biochemistry and Molecular Biology

American Society for Pharmacology and Experimental Therapeutics

American Heart Association, Fellow of the Council on Basic Cardiovascular Sciences

Fellow of the International Society for Heart Research (FISHR)

ADVISORY AND EDITORIAL BOARDS:

Member, Program Project Study Section A, USPHS-NHLBI 1992-1996

Molecular Signaling Study Committee, Basic Science Council, American Heart Association 1995-2000

American Heart Association, Northeast Research Consortium Peer Review Group, Cardiovascular Physiol & Pharm, Molecular Biology of Muscle, and Molecular Signaling. 1998-2002

Ad Hoc Reviewer, Cardiovascular and Renal (CVB) Study Section, USPHS-NHLBI 1999

Howard Hughes Medical Institute Research, Medical Student Fellowship Awards Review Panel 1999-2000

Cardiovascular A (CVA) Study Section, Member, USPHS-NHLBI 2000-2004

Chair, NIH Scientific Review Group ZRG1 CVRS-C 02 M, Cardiac Therapies 2010

Program Committee, Basic Science Council, American Heart Association 1994-1997

Abstract Reviewer, American Heart Association Scientific Sessions 1989-2001, 2006-2009, 2011, 2014

Editorial Boards:

Circulation Research 1995-2013

Journal of Cardiovascular Pharmacology 1998-present

Journal of Molecular & Cellular Cardiology 2000-present

American Journal of Physiology 1999-2015

Circulation 2004-2016

Journal of Biological Chemistry 2006-2011

Journal of Cardiovascular Pharmacology, Associate Editor 2008-present

Faculty of 1000, Cardiovascular Physiology 2005-present

Faculty of 1000, Pharmacology & Drug Discovery Advisory Board 2009-present

Columbia University; Department of Medicine, Graduation prizes committee 2002-2004

Molecular Pharmacology Division of ASPET; Secretary-Treasurer 2003-2005

Women in Pharmacology Committee – ASPET 2003-2010

American Heart Association: Chair - Scientific Conference on Molecular Mechanisms of Growth, Death and Regeneration in the Myocardium (with Dr. David Kass) August, 2005

New York Academy of Medicine, Chair, Selection Committee for the Glorney-Raisbeck Fellowship in Cardiovascular Diseases 2005-2008

American Heart Association - Chair Northeast 5B Study Group, Basic Cell and Molecular Biology, Molecular Signaling and Cardiovascular Development April, 2005

American Heart Association, National, Research Committee, Strategic Planning Subcommittee 2005-2008

Chair Stem Cell Task Force 2007-2009

International Society for Heart Failure Research, North American Section Council Member 2006-2012

Nominating Committee for ISHR, North American section officers 2009-2011

North American section program/steering committee 2009-2011

Katz Prize Selection Committee, American Heart Association, Council on Basic Cardiovascular Science 2008-2012

Cardiac Contractility, Hypertrophy, and Failure (CCHF), Study Section, member USPHS-NHLBI 2012-2015

Committee on Appointments and Promotions, Columbia University 2007-2012

Dean’s Committee on Faculty Diversity, Columbia University 2012-present

American Heart Association – Basic Cardiovascular Science Council, Leadership Committee 2014-2018

Columbia University Senate 2016-2018

Honors and Awards

Thomas Smith Memorial Lecture, American Heart Associattion, 2019

NIH Grants

  • A NOVEL MOLECULAR DETERMINANT OF THE CARDIAC BETA1-ADRENERGIC RECEPTOR RESPONSE (Federal Gov)

    Apr 1 2018 - Feb 28 2022

    DISTRICT PROTEIN KINASE C-DELTA SIGNALING MODES IN CARIOMYOCYTES (Federal Gov)

    Nov 15 2014 - Oct 31 2018

    DISTRICT PROTEIN KINASE C-DELTA SIGNALING MODES IN CARIOMYOCYTES (Federal Gov)

    Nov 15 2014 - Oct 31 2018

    PKD ISOFORMS IN HEART (Federal Gov)

    Aug 15 2012 - Jul 31 2016

    PROTEIN KINASE C-DELTA ACTIONS IN CARDIOMYOCYTES (Federal Gov)

    Aug 15 2004 - Apr 30 2015

    P66SHC SIGNALING FUNCTIONS IN CARDIOMYOCYTES (Federal Gov)

    Apr 15 2010 - Mar 31 2015

    B1-/B2-ADRENERGIC RECEPTOR MECHANISMS IN CARDIOMYOCYTES (Federal Gov)

    Jul 1 2003 - Jun 30 2009