Stephen P. Goff, PhD

Academic Appointments

  • Higgins Professor of Biochemistry and Molecular Biophysics
  • Professor of Microbiology & Immunology
Stephen P. Goff, PhD

Goff has been interested in viruses and their interactions with the host throughout his career. Over the past three decades, the Goff laboratory at Columbia University has focused on the replication of the mammalian retroviruses, including the Moloney murine leukemia virus and human immunodeficiency virus type 1 (HIV-1), aiming to define the functions of each of the viral gene products and to identify host proteins with which the viruses interact. His group studies all aspects of the viral life cycle. He has also made a major effort toward the characterization of the Abelson murine leukemia virus oncogene, its regulation, and its downstream signaling pathway. The laboratory makes use of the two-hybrid system, proteomic methods, and somatic cell genetics to identify host proteins that impact the viruses, including those that either restrict or enhance virus replication. The lab has identified and characterized a novel host protein, termed ZAP for zinc finger antiviral protein, that blocks gene expression of many viruses, including the murine leukemia viruses, Ebola, Sindbis, and HIV-1, by degrading viral mRNAs. Lab members have also characterized a protein complex responsible for the silencing of retroviral DNAs in embryonic stem (ES) cells, and identified a zinc finger protein, ZFP809, as an ES-cell specific recognition molecule that binds the proviral DNA and brings TRIM28 to locally modify chromatin.

Goff is strongly committed to the training of students and fellows and preparing them for careers in science. To date he has trained about thirty-five PhD students and a similar number of postdoctoral fellows. His alumni include heads of laboratories at universities in the US, UK, Australia, Chile, China, Taiwan, and Israel; department chairs; investigators at the NIH; and scientists at many biotech companies and large pharmaceutical firms.

Molecular Biology of retrovirus replication; tyrosine kinases and signal transduction pathways.

Departments and Divisions

  • Department of Biochemistry and Molecular Biophysics
  • Department of Microbiology & Immunology

Education and Training

  • AB, 1973 Biophysics, Amherst College
  • PhD, 1978 Biochemistry, Stanford University Medical Center
  • Fellowship: 1981 Massachusetts Institute of Technology

Centers / Institutes / Programs

  • Herbert Irving Comprehensive Cancer Center

Lab Locations

  • Hammer Health Sciences Building

    701 West 168th Street
    New York, NY 10032
    Phone:
    (212) 305-3794
    Lab Phone:
    (212) 305-7956
    Fax:
    (212) 305-5106
    Email:
    spg1@cumc.columbia.edu

Contact Info

  • 2123055106
  • (212) 305-3794

Presentations

1/22/07 Gilead Sciences, Foster City, CA Dr. Romas Geleziunas

4/11/07 Biology Dept., Princeton Univ., Princeton, NJ Dr. Lynn Enquist

4/13/07 Cancer Center Retreat, CU, Wave Hill, NY Dr. Riccardo Dalla Favera

5/8/07 Scripps Research Institute, La Jolla, CA Dr. Bruce Beutler

6/4/07 Dept. of BMBB, U Minn., Minneapolis, MN Ms. Patrycja Lech

8/28/07 Ubiquitin in Viral Infection, NIH, Bethesda, MD Dr. Eun-Chung Park

9/8/07 Biochemistry Dept. Retreat, New Paltz, NY Dr. Parychtery Srinivasan

9/10/07 Science Meeting, Janelia Farm, Ashburn, VA Dr. Thomas Cech

9/17/07 Nankai University, Tianjin, China President Zehi Rao

9/18/07 Institute of Biophysics, Chin. Acad.Sci., Beijing, Dr. Guangxia Gao

10/16/07 Dept. of Physiology, Columbia Univ. Dr. Andrew Marks

11/5/07 Institut de Recherche Cliniques de Montreal, Cn Dr. Eric Cohen

11/16/07 Shipley Symp., Microbiol., Harvard Med. Bos MA Dr. John Mekalanos

11/20/07 DRP NCI/FCRC, Frederick, MD Dr. John Coffin

12/11/07 Biology Dept., Johns Hopkins Univ., Baltimore, MD Dr. Karen Beemon

1/24/08 MBG Dept., Johns Hopkins U. Med. S, Balt., MD Dr. Carol Greider

3/11/08 Monogram Biosciences, S. San Francisco, CA Dr. Chris Petropoulos

3/26/08 S. Edward Selkin Lecture, UTSW, Dallas, TX Dr. Michael Norgard

3/27/08 Microbiology Dept., UTSW, Dallas, TX Dr. Beth Levine

4/3/08 Fox Chase Cancer Center, Philadelphia, PA Dr. Richard Katz

4/16/08 Dept. of Chemistry, City College, New York, NY Dr. Tom Haines

4/29/08 Microbiology/Pathology, Wash. U., St. Louis, MO Dr. Skip Virgin

5/22/08 Session Chair, CSH Retrovirus Meeting, CSH, NY Dr. Alice Telesnitsky

5/30/08 HIV Vaccines, Inst. Adv. Study, Princeton NJ Dr. Arnold Levine

6/24/08 FASEB Conf. Virus Assembly, Saxtons River, VT Dr. Robert Garcea

6/27/08 Struct. AIDS-related Systems, NIH, Bethesda, MD Dr. Wes Sundquist

7/7/08 Plenary Talk, ASM 2008, Melbourne, Australia Dr. Gilda Tachedjian

7/7/08 Division 2 presentation, ASM 2008, Melbourne Dr. Hans Netter

7/8/08 MacFarlane Burnett Inst., Melbourne, Australia Dr. Gilda Tachedjian

9/16/08 Third Int. Conf. Retrov. Integrase, Woods Hole, MA Dr. Alan Engelman

10/3/08 Microbiology Dept. Retreat, IBM Cntr., Palisad, NY Dr. Sankar Ghosh

10/6/08 CSN Section, HICC Retreat, Wave Hill, Bronx, NY Dr. Riccardo Dalla Favera

10/14/08 Dept. of Micro., Med. Coll. of Wisc., Milwaukee, WI Dr. Li Wu

10/17/08 Keynote, West Coast Rtrvrs Mtng, Palm Spr, CA Dr. Jonathan Karn

11/20/08 Burnham Institute, San Diego, CA Dr. Yong Cang

1/13/09 Virology minisymposium, JHU, Baltimore, MD Dr. Karen Beemon

3/17/09 HHMI Science Meeting, Janelia Farm, Ashburn VA Dr. Thomas Cech

3/26/09 Grand Rounds, Heme/Onc, CU P & S, NY, NY Dr. Ed Gelmann

5/4/09 6th Internat’l. Virus Assembly Symp., Crete, Greece Dr. Polly Roy

5/13/09 Pitt. Cntr. for HIV Protein Int., U Pitt., Pittsburgh, PA Dr. Angela Gronenborn

6/4/09 Microbiology Dept., Northwestern Univ., Chg, IL Andrew Pincetic

7/22/09 XMRV Workshop, NCI, Bethesda, MD Dr. Stuart LeGrice

9/1/09 Hepatitis B Virus Int’l Meeting 2009, Tours, France Dr. Stephen Locarnini

9/7/09 69th Annual Int’l Congress of FIP, Istanbul, Turkey Dr. Bernard Poggi

9/10/09 Microbiology Dept. Retreat, Palisades, NY Dr. Sankar Ghosh

9/11/09 Biology Dept. Retreat, Tarrytown, NY Dr. Marty Chalfie

9/17/09 Microbiology Dept. Faculty Seminar, Columbia, NY Dr. Sankar Ghosh

9/21/09 Frontiers of Retrovirology, Montpellier, France Dr. Kuan-Teh Jeang

9/25/09 Virus and Immunol. Unit, Pasteur Inst., Paris, Fr Dr. Olivier Schwartz

10/27/09 Dept. Microbiol. & Mol. Genet., UMDNJ, Newa, NJ Dr. David Kaback

11/4/09 Cancer Center CSN Section Seminar, Columbia, NYDr. Jan Kitajewski

1/12/10 Keynote, Keystone Symp.HIV Bio Path., Santa Fe, NM Dr. Thomas Hope

2/19/10 17th CROI meeting, plenary lecture, San Franciso, CA Dr. John Coffin

3/2/10 Frederick Hutchinson Cancer RC, Seattle, WA Dr. Bob Eisenman

4/1/10 Dist. Res. Career Award, OSU, Columbus, OH Dr. K. Boris-Lawrie

4/2/10 Center for Retrovirus Res., OSU, Columbus, OH Dr. Patrick Green

4/8/10 GSAS invited speaker, Rutgers, New Brunswick, NJ Jon Cruz

4/12/10 OnLine Webinar, Univ. of Utah, Salt Lake City, UT Dr. Wes Sundquist

4/19/10 HHMI Science Meeting, Chevy Chase, MD Dr. Robert Tjian

4/30/10 Chair & Summary, Cent’nial RV Meeting, Prague, CZ Dr. Anne Skalka

5/5/10 4th Int’nl Wkshp, Dept. of ID, Guy’s Hsp., London Dr. Monica Agromayor

5/7/10 Cntr. Res. in ID, University College, Dublin, Ireland Dr. Mojgan Naghavi

5/10/10 Drexel Inst. Biotech. Virol. Res., PA Biotech Cntr., PA Dr. Tim Block

5/17/10 U Mass Med. Center, Worcester, MA Dr. Victor Ambrose

5/26/10 NYSTEM 2010 Awardees Program, CUNY, NY Dr. David Anders

5/27/10 Verma Symposium Ophth., Columbia Univ., NY, NY Dr. Janet Sparrow

6/22/10 NY Stem Cell Day, Columbia Univ., NY, NY Dr. G. Vunjak-Novakovic

7/15/10 4th Int’nl Symp. Infect. Immunol., Dunhuang, China Dr. Guangxia Gao

9/1/10 HICCC, CSR section seminar, Columbia, NY, NY Dr. Jan Kitajewski

9/29/10 Viruses, Genes, and Cancer, Venice, Italy Dr. Genoveffa Franchini

12/10/10 HHMI Investigator Review, Chevy Chase, MD Dr. Robert Tjian

3/8/11 Vaccine Research Center, NIH, Bethesda MD Dr. Richard Koup

4/21/11 Cleveland Virol Grp., Case W./Cleveland Clinic, OH Dr. Jonathan Karn

5/12/11 Lady Davis Institute, McGill Univ., Montreal, CA Dr. Andrew Mouland

7/16/11 Keynote Address, ASV Symp., Minneapolis, MN Dr. Terry Dermody

9/8/11 Microbiology Dept. Retreat, Basking Ridge, NJ Dr. Sankar Ghosh

9/16/11 Biochemistry Dept. Retreat, Basking Ridge, NJ Dr. Thomas Maniatis

10/12/11 Institute for Advanced Studies, Princeton, NJ Dr. Benjamin Greenbaum

1/10/12 Keynote Add., Ann. Meeting Revson Fnd’n, NY, NY Dr. Cliff Tabin

2/8/12 14th International ATM Workshop, New Delhi, India Dr. Tej Pandita

2/15/12 HHMI Science Meeting, Chevy Chase, MD Dr. Robert Tjian

3/1/12 ICMB, University of Texas, Austin, TX Dr. Robert Krug

3/22/12 Microbiology, NYU Medical Center, NY, NY Dr. Claudio Basilico

3/27/12 Microbiology & Immunology, UAB, Birmingham, AL Dr. Peter Prevelige

4/11/12 WALS, NIH, Bethesda, MD Dr. Kuang-Teh Jeang

5/9/12 Microbiology Dept., U. of Chicago, Chicago, IL Dr. Tatyana Golovkina

5/11/12 Molecular Genetics, Cornell University, Ithaca, NY Dr. Volker Vogt

6/19/12 HIV Structure Center Meeting, NIGMS, Bethesda, MD Dr. Wes Sundquist

9/6/12 Microbiology Dept. Retreat, Basking Ridge, NJ Dr. Sankar Ghosh

10/3/12 Plum Island Animal Disease Center, Greenpoint, NY Dr. Teresa de los Santos

10/19/12 Infect., Immunol., & Inflam. Symp., ICR, London, UK Dr. Ari Fassati

10/26/12 24th Workshop on Retroviral Path., Philadelphia, PA Dr. Susan Ross

12/14/12 HIV DRP Conf. on Trafficking, NCI, Frederick, MD Dr. Stuart LeGrice

3/6/13 Cancer Center CSN Section Seminar, Columbia, NY Dr. Jan Kitajewski

3/8/13 Palm Sprgs Symp. on HIV/AIDS, Palm Springs, CA Drs. H. Fan, J. Zack

4/8/13 bluebird biosciences, Cambridge, MA Dr. Mitch Finer

5/16/13 Micro Dept. Lunch Seminar Prog., Columbia, NY, NY Dr. Sankar Ghosh

6/10/13 FASEB Conference, Mobile DNA, Big Sky, MT Dr. Jef Boeke

6/21/13 Kuan-Teh Jeang Memorial Symp., NIH, Beth, MD Dr. Michael Gottesman

8/8/13 25th Wkshp Retroviral Path., U Is, Reykyavik, Iceland Dr. Hung Fan

8/29/13 Keynote Shenquistea Symp.,Princeton U.,Princeton NJ Kai Wu

9/16/13 Keynote Addr., Frontiers of Retrovir., Cambridge, UK Dr. Andrew Lever

9/25/13 Micro. Emerging Path., Mt. Sinai Sch. Med., NY, NY Dr. Viviana Simon

10/3/13 Microbiology Grad. Prog., Yale Univ., New Haven CT Dr. Richard Sutton

10/10/13 Inst. Exptl. Hematol., Med. Sch., Hannover, Germany Dr. Axel Schambach

1/22/14 Innate Immunity to Viral Inf., Keystone Symp., CO Dr. Charles Rice

3/5/14 HHMI Science Meeting, Chevy Chase, MD Dr. Robert Tjian

3/12/14 Microbiology, Univ. Penn, Philadelphia, PA Dr. Matthew Weitzman

4/10/14 Murray Lect., Univ. W. Ontario, London, ON, Canada Dr. James Dikeakos

5/2/14 Mol. Cell. Biochem., Indiana Univ. Bloomington, IN Dr. Tuli Mukhopadhyay

5/6/14 Microbiol. Immunol., Harvard Med. Sch., Boston, MA Dr. David Knipe

5/10/14 Salk Institute HINT ProgProj SAB, San Diego, CA Dr. John Young

8/12/14 7th Intn’l Symp Infect., Inst of Biophys, CAS, Beijing Dr. Guangxia Gao

10/7/14 Microbiology Dept., Univ. of Wash., Seattle, WA Dr. Jaisri Linggappa

10/8/14 Fred Hutchinson Cancer Center, Seattle WA Dr. Robert Eisenman

11/7/14 Int’l. Symp. Vir., Univ. Andrés Bello, Santiago, Chile Dr. Simon Litvak

3/13/15 Fred Hutchinson Cancer Center, Seattle WA Dr. Robert Eisenman

4/13/15 Hilleman Lecture, Micro Dept., U of Chicago, IL Dr. Olaf Schneewind

7/7/15 Inaugural Heslin Mem. Symp., Einstein Coll Med, NY Dr. Jack Lenz

7/10/15 Basic Sciences, Fred Hutchinson CC, Seattle WA Dr. Jonathan Cooper

10/6/15 Center for Stem Cell Biology, NYU, NY, NY Dr. Claudio Basilico

12/1/15 Keynote, World AIDS Day, Rochester U. CFAR, NY Dr. Steven Dewhurst

12/17/15 Lewis/Hirschl Trust Lecture, Columbia, NY, NY Dr. Lee Goldman

1/5/16 Biochemistry Dept. Faculty Seminar, Columbia, NY Dr. Stavros Lomvardas

2/25/16 Cancer Res., Karolinska Insitutet, Stockholm, Sweden Dr. Dan Grander

3/17/16 Microbiology Dept. Faculty Seminar, Columbia, NY Dr. Sankar Ghosh

3/24/16 Keystone Symp. HIV Persistence, Squaw Creek, CA Dr. David M. Margolis

3/31/16 Dept. Infect. Dis. and Imm. Scripps East, Jupiter, FL Dr. Susana Valente

4/1/16 Miami CFAR, U Miami School of Med., Miami, FL Dr. Ronald Desrosiers

4/19/16 HHMI Science Meeting, Chevy Chase, MD Dr. Robert Tjian

4/28/16 Board of Advisors, Columbia Univ., NYC, NY Dr. Roy Vagelos

5/10/16 Dept. Microbiol.-Immunol., NW Univ., Chicago, IL Dr. Mojgan Naghavi

10/13/16 HICCC Annual Retreat, Tarrytown NY Dr. Stephen Emerson

10/13/16 Chair, CSH Meeting on History of AIDS, CSH NY Dr. John Coffin

10/20/16 Skalka Symposium, Fox Chase CC, Philadelphia, PA Dr. Richard Katz

10/26/16 Boston University, Microbiology Dept., Boston MA Dr. Andrew Henderson

11/12/16 Shenzhen Int. Inst. Biomed. Res., Shenzhen, China Dr. Bernard Roizman

2/20/17 Keynote address, Keystone Symp., Santa Fe NM Dr. Akiko Iwasaki

5/10/17 Hilldale Lecture, Univ. of Wisconsin, Madison WI Dr. Nathan Shearer

5/23/17 Prince Hitachi Prize for Comparative Oncology Dr. Tomoyuki Kitagawa

5/24/17 Japanese Found. for Cancer Research, Tokyo Japan Dr. Tetsuo Noda

Patents

1990 Patent #4,943,531: Expression of enzymatically active reverse transcriptase (U.S.: issued 7/24/90).

1993 Patent #5,202,259: Expression of HIV reverse transcriptase (U.S.: issued 4/13/93).

1993 Patent #5,256,554: Expression of HIV reverse transcriptase (U.S.: issued 10/26/93).

1994 Patent #5,278,056: Retroviral packaging cell lines and process of using same (U.S.: issued 1/11/94).

1998 Patent #5,773,225: Screening method for the identification of compounds capable of abrogation of HIV-1 gag-cyclophilin complex formation (U.S.: issued 6/30/98)

1999 Patent #5,872,213: Identification and characterization of a novel human protein designated integrase interactor 1, that binds specifically to the human immunodeficiency virus type 1 integrase (U.S.: issued 2/16/99)

2000 Patent #6,136,582: Reverse transcriptase of Moloney murine leukemia virus with RNA polymerase activity (U.S.: issued 10/24/00)

2001 Patent #6,222,024: Nucleic acids encoding a human immunodeficiency virus type 1 (HIV-1) integrase interactor protein (Ini-1) (U.S.: issued 4/24/01)

2002 Patent #6,372,502: Retroviral packaging cell lines and processes of using same (U.S.: issued 4/16/02)

2002 Patent #6,469,153: EIP-1 and EIP-3 genes, envelope-interacting proteins, EIP-1 and EIP-3 (U.S.: issued 10/22/02)

2004 Patent #6,812,025: Two-hybrid assay that detects HIV-1 reverse transcriptase dimerization (U.S.: issued 11/2/04)

Committees / Societies / Memberships

1995 Fellow, American Academy of Arts and Sciences

1997 Fellow, American Academy of Microbiology

2006 Member, National Academy of Sciences

2006 Member, National Academy of Medicine

2007 Fellow, American Association for the Advancement of Science

Honors and Awards

1982-1986 Irma T. Hirschl Career Development Award; 1982-1985 Searle Scholarship Award; 1985 Harold and Golden Lamport Research Award, Columbia Univ.; 1990, 2003 MERIT award, NCI; 1991 Dean's Distinguished Lecture in the Basic Sciences, Columbia Univ.; 1995 Fellow, American Academy of Arts and Sciences 1996 Honorary degree (Doctor of Science), Amherst College; 1997 Fellow, American Academy of Microbiology; 2006 Member, National Academy of Sciences; 2006 Member, National Academy of Medicine; 2007 Fellow, American Association for the Advancement of Science; 2007 Shipley Lecture, Harvard Microbiology Department; 2008 S. Edward Selkin Lecture, University of Texas SW; 2010 Distinguished Research Career Award, Ohio State University; 2015 Hilleman Lecture, University of Chicago, Chicago IL; 2017 D.C. White Research and Mentoring Award of the ASM; 2017 Prince Hitachi Prize in Comparative Oncology

NIH Grants

  • MECHANISMS OF SILENCING OF RETROVIRAL DNAS IN EMBRYONIC CELL LINES (Federal Gov)

    Jan 8 2020 - Dec 31 2024

    ROLE OF CHROMATIN ASSOCIATED HOST FACTORS IN REGULATION OF RETROVIRAL REPLICATION (Federal Gov)

    Mar 1 2020 - Feb 28 2023

    ROLE OF HEME OXYGENASE 2 IN TRAFFICKING AND REGULATION OF MYRISTOYLATED PROTEINS (Federal Gov)

    Feb 1 2020 - Jan 31 2022

    MICROTUBLE NETWORKS AND VIRUS TRAFFICKING (Federal Gov)

    Apr 1 2014 - Apr 30 2020

    CONSTRUCTION AND ANALYSIS OF RETROVIRUS MUTANTS (Federal Gov)

    Aug 1 1981 - Jan 31 2020

    MICROTUBLE NETWORKS AND VIRUS TRAFFICKING (Federal Gov)

    May 1 2014 - Apr 30 2019

    MICROTUBLE NETWORKS AND VIRUS TRAFFICKING (Federal Gov)

    Apr 1 2014 - Apr 30 2019

    CONSTRUCTION AND ANALYSIS OF RETROVIRUS MUTANTS (Federal Gov)

    Aug 1 1981 - Jan 31 2019

    CONSTRUCTION AND ANALYSIS OF RETROVIRUS MUTANTS (Federal Gov)

    Aug 1 1981 - Jan 31 2019

    REGULATIONS OF HIV-1 GENE EXPRESSION IN LATENCY BY YY1,RUVB2, AND ZAP (Federal Gov)

    Aug 14 2013 - Jul 31 2016

    REGULATIONS OF HIV-1 GENE EXPRESSION IN LATENCY BY YY1,RUVB2, AND ZAP (Federal Gov)

    Aug 14 2013 - Jul 31 2016

    CHARACTERIZATION OF THE RETROVIRAL SILENCING MACHINERY IN EM BRYONIC STEM CELLS (NY State Gov)

    Jan 1 2009 - Dec 31 2012

    ROLE OF CA SUMYOLATION AND NUCLEAR PROTEINS BAF AND : AP2A I N THE NU (Private)

    Jul 1 2007 - Jun 30 2012

    THE ROLE OF XMRV A NOVEL XENOTROPIC MURINE RETROVIRUS IN HUM AN PROSTATE CANCERS (Federal Gov)

    Apr 23 2007 - Apr 22 2011

    ASSEMBLY AND EXPORT OF HIV MESSENGER RIBONUCLEOPROTEINS (Federal Gov)

    Jan 1 2009 - Dec 31 2010

    ASSEMBLY AND EXPORT OF HIV MESSENGER RIBONUCLEOPROTEINS (Federal Gov)

    Jan 1 2009 - Dec 31 2010

Lab Members

  • Yiping Zhu, Postdoctoral Fellow
  • Oya Cingoz, Postdoctoral Fellow
  • Michael Metzger, Postdoctoral Fellow
  • Sefef Onal Tinaztepe, Graduate Research Assistant
  • Marina Ermakova, Graduate Research Assistant
  • Marlene Arroyo, Graduate Research Assistant
  • Josef Sabo, Postdoctoral Fellow

Publications

  • Wolf, D., and Goff, S.P. (2007) TRIM28 mediates primer binding site-targeted silencing of murine leukemia virus in embryonic cells. Cell 131, 46-57.
  • Studamire, B., and Goff, S.P. (2008) Host proteins interacting with the Moloney murine leukemia virus integrase: multiple transcriptional regulators and chromatin binding factors. Retrovirology 5, 48.
  • Wolf, D., and Goff, S.P. (2009) Embryonic stem cells use ZFP809 to silence retroviral DNAs. Nature 458, 1201-1204.
  • Valente, S.T., Gilmartin, G.M., Venkataraman, K., and Goff, S.P. (2009) HIV-1 mRNA 3' end processing is distinctively regulated by eIF3f, CDK11, and splice factor 9G8. Mol. Cell 36, 279-289.
  • Hogg, J.R., and Goff, S.P. (2010) Upf1 senses 3'UTR length to potentiate mRNA decay. Cell 143, 379-389.
  • Schlesinger, S., Lee, A., Wang, G.Z., Green, L., and Goff, S.P. (2013) Proviral silencing in embryonic cells is regulated by Yin Yang 1. Cell Rep. 4, 50-58.
  • Sabo, Y., Walsh, D., Barry, D.S., Tinaztepe, S., de los Santos, K., Goff, S.P., Gundersen, G.G., and Naghavi, M.H. (2013) HIV-1 induces the formation of stable microtubules to enhance early infection. Cell Host Microbe 14, 535-546.
  • Arriagada, G., Metzger, M.J., Muttray, A., Sherry, J., Reinisch, C., Street, C., Lipkin, W.I., and Goff, S.P. (2014) Activation of transcription and retrotransposition of a novel retroelement, Steamer, in neoplastic hemocytes of the mollusk Mya arenaria. Proc. Natl. Acad. Sci. USA 111, 14175-14180.
  • Metzger, M.J., Reinisch, C., Sherry, J., and Goff, S.P. (2015) Horizontal transmission of clonal cancer cells causes leukemia in soft-shell clams. Cell 161, 255-263.
  • Metzger, M.J., Villalba, A., Carballal, M.J., Iglesias, D., Sherry, J., Reinisch, C., Muttray, A.F., Baldwin, S.A., and Goff, S.P. (2016) Widespread transmission of independent cancer lineages within multiple bivalve species. Nature 534, 705-709.
  • Wang, G.Z, Wang, Y., and Goff, S.P. (2016) Histones are rapidly loaded onto unintegrated retroviral DNAs soon after nuclear entry. Cell Host Microbe 20, 798-809.
  • Zhu, Y., Luo, S., Tong, L., and Goff, S.P. (2017) Heme oxygenase 2 binds myristate to negatively regulate retrovirus assembly and TLR4 signaling. Cell Host Microbe 21, 220-230.
  • Wang, C., and Goff, S.P. (2017) Differential control of retrovirus silencing in embryonic cells by proteasomal regulation of the ZFP809 retroviral repressor. Proc. Natl. Acad. Sci. USA 114, E922-E930.
  • Zhu, Y., Wang, G.Z., Cingöz, O., and Goff, S.P. (2018) NP220 mediates silencing of unintegrated retroviral DNA. Nature 564, 278-282.

For a complete list of publications, please visit PubMed.gov