Rene Hen, PhD

Academic Appointments

  • Professor of Pharmacology (in Psychiatry)
  • Professor of Neuroscience

Current Administrative Positions

  • Director, Division of Integrative Neuroscience
Rene Hen, PhD

Departments and Divisions

  • Department of Psychiatry
    Division of Systems Neuroscience
  • Department of Molecular Pharmacology and Therapeutics
  • Department of Neuroscience

Lab Locations

  • Kolb Research Annex

    40 Haven Ave
    7th floor, Room 767
    New York, NY 10032
    Phone:
    (646) 774-7107
    Email:
    rh95@cumc.columbia.edu

Committees / Societies / Memberships

Member, Kavli Institute for Brain Science

Research Interests

  • Models of Psychiatric Disorders
  • Stem Cell Biology

NIH Grants

  • INVESTIGATING THE ROLE OF HILAR MOSSY CELLS IN ANXIETY-LIKE BEHAVIOR (Federal Gov)

    Jul 1 2018 - Jun 30 2022

    TRANSLATIONAL NEUROSCIENCE TRAINING GRANT (Federal Gov)

    Jul 1 2016 - Jun 30 2021

    HIPPOCAMPALNEUROGENESIS, PATTERN SEPARATION & AGE- RELATED COGNITIVE IMPAIRMENTS (Federal Gov)

    Sep 1 2013 - May 31 2019

    ADULT HIPPOCAMPAL NEUROPLASTICITY AND DEPRESSION (Federal Gov)

    May 23 2014 - Apr 30 2019

    HHMI GILLIAM FELLOWSHIPS (Private)

    Jul 1 2011 - Jun 30 2018

    HIPPOCAMPAL NEUROGENESIS, PATTERN SEPARATION & AGE- RELATED COGNITIVE IMPAIRMENTS. (Federal Gov)

    Sep 1 2013 - May 31 2018

    HIPPOCAMPALNEUROGENESIS, PATTERN SEPARATION & AGE- RELATED COGNITIVE IMPAIRMENTS (Federal Gov)

    Sep 1 2013 - May 31 2018

    HIPPOCAMPAL NEUROGENESIS, PATTERN SEPARATION & AGE- RELATED COGNITIVE IMPAIRMENTS. (Federal Gov)

    Sep 1 2013 - May 31 2018

    TRANSLATIONAL NEUROSCIENCE TRAINING GRANT (Federal Gov)

    Jul 1 1977 - Jun 30 2016

    EFFECTS OF NEUROGENIC DRUG TREATMENTS ON RODENT BEHAVIOR (Private)

    Apr 1 2013 - Dec 31 2015

    ACUTE INHIBITION OF ADULT-BORN GRANULE CELLS AND ITS EFFECT ON ANTIDEPRESSANT ACTION (Federal Gov)

    Sep 1 2013 - Aug 31 2015

    ACUTE INHIBITION OF ADULT-BORN GRANULE CELLS AND ITS EFFECT ON ANTIDEPRESSANT ACTION (Federal Gov)

    Sep 1 2013 - Aug 31 2015

    EFFECT OF S38093 ON PATTERN SEPARATION IN MICE (Private)

    Jan 15 2013 - Jan 14 2015

    THE ROLE OF NEUROGENESIS IN HIPPOCAMPAL EXCITABILITY AND THE ANTIDEPRESSANT RESPONSE (Private)

    Jul 15 2011 - Jul 14 2014

    HIPPOCAMPAL NEUROGENESIS IN A TRANSLATIONAL MODEL OF ANOREXIA NERVOSA (Private)

    Jul 1 2011 - Jun 30 2013

    MODULATING PLASTICITY IN ADULT-BORN NEURONS OF THE DENTATE G YRUS (Federal Gov)

    Jul 1 2011 - Oct 31 2012

    MODULATING PLASTICITY IN ADULT-BORN NEURONS OF THE DENTATE G YRUS (Federal Gov)

    Jul 1 2011 - Oct 31 2012

    ANALYSIS OF THE ROLE OF HIPPOCAMPAL ADULT-BORN NEURONS IN BE HAVIOR AND PHYSIOLOGY (Federal Gov)

    Jul 1 2009 - Jun 30 2012

    MECHANISMS MEDIATING THE ANTIDEPRESSANT RESPONSE (Private)

    Jul 1 2010 - Jun 30 2012

    ANALYSIS OF THE ROLE OF HIPPOCAMPAL ADULT-BORN NEURONS IN BE HAVIOR AND PHYSIOLOGY (Federal Gov)

    Jul 1 2009 - Jun 30 2012

    EXPLORING THE NEUROBIOLOGY OF ANTIDEPRESSANT RESPONSIVENESS - PRECLINICAL AND CLINICAL ACTIONS OF AN (Federal Gov)

    Jun 30 2008 - Dec 31 2010

    AGOMELATINE EFFECTS IN NEUROGENSES IN MICE (Private)

    Aug 1 2007 - Aug 31 2010

    THE ROLE OF SEROTONIN RECEPTOR 1B SIGNALS ON OBSESSIVE-COMPU LSIVE DISORDER SYMPTOMS (Private)

    Jul 1 2007 - Jun 30 2010

    EFFECTS OF STRESS AND ANTIDEPRESSANTS ON CELLULAR AND CIRCUIT PLASTICITY OF ADULT-BORN HIPOCAMPAL NEURONS (Private)

    Jul 1 2006 - Jun 30 2008

Publications

  • Luna VM, Anacker C, Burghardt N, Khandaker H, Andreu V, Millette A, Leary P, Ravenelle R, Jimenez J, Mastrodonato A, Denny CA, Fenton A, Scharfman H, Hen R. (2019); Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs int the dentate gyrus. Science. 364(6440):578-583.
  • Anacker C., Luna V., Stevens G., Millette A., Shores R., Jimenez JC., Chen B., Hen R (2018); Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus;Nature
  • Donaldson ZR, Hen R. (2015). From psychiatric disorders to animal models: a bidirectional and dimensional approach. Biol Psychiatry. 77(1):15-21. PMCID: PMC4135025.
  • Denny CA, Kheirbek MA, Alba EL, Tanaka KF, Brachman RA, Laughman KB, Tomm NK, Turi GF, Losonczy A, Hen R. (2014). Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis. Neuron. 83(1):189-201. PMCID: PMC4169172.
  • Kheirbek MA, Hen R. (2014). Add neurons, subtract anxiety. Sci Am. 311(1):62-7. PMCID: PMC4165637.
  • Drew LJ, Fusi S, Hen R. (2013). Adult neurogenesis in the mammalian hippocampus: why the dentate gyrus? Learn Mem. 20(12):710-29. Review. PMCID: PMC3834622.
  • Kheirbek MA, Drew LJ, Burghardt NS, Costantini DO, Tannenholz L, Ahmari SE, Zeng H, Fenton AA, Hen R. (2013). Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus. Neuron. 77(5):955-68. PMCID: PMC3595120.
  • Kheirbek MA, Klemenhagen KC, Sahay A, Hen R. (2012). Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders. Nat Neurosci.15(12):1613-20. PMCID: PMC3638121.
  • Sahay A, Scobie KN, Hill AS, O'Carroll CM, Kheirbek MA, Burghardt NS, Fenton AA, Dranovsky A, Hen R. (2011). Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation. Nature. 472(7344):466-70. PMCID: PMC3084370.
  • Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O,Belzung C, Hen R. (2003). Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science, 301(5634): 805-9. PMID: 12907793.