Neil L. Harrison, PhD

Academic Appointments

  • Professor of Anesthesiology
  • Professor of Molecular Pharmacology and Therapeutics
Neil L. Harrison, PhD

The Harrison laboratory is interested in synaptic transmission, especially at inhibitory synapses, which are necessary for the normal processing of information in the mammalian brain. Failure of synaptic inhibition leads to epilepsy, while enhancement of synaptic inhibition is associated with reduced anxiety, muscle relaxation, sedation, hypnosis and anesthesia. The lab studies the details of inhibitory synaptic function, its modulation and plasticity, using a variety of modern electrophysiological and molecular biological techniques. Projects within the lab study these synapses at several different levels of organization, including brain slice, single cell and subcellular preparations. A major focus of the lab is on the GABA-A receptor, the principal receptor protein at inhibitory synapses in the brain. The lab personnel include physiologists, biophysicists, molecular biologists and pharmacologists.

Departments and Divisions

  • Department of Molecular Pharmacology and Therapeutics
  • Department of Anesthesiology

Lab Locations

  • CUIMC/Presbyterian Hospital and Vanderbilt Clinic

    622 West 168th Street
    Box 46 Mail Code 5
    New York, NY 10032
    Phone:
    (212) 304-6459
    Email:
    nh2298@cumc.columbia.edu

Research Interests

  • Biophysics/Ion Channels
  • Cellular/Molecular/Developmental Neuroscience
  • Synapses and Circuits

NIH Grants

  • PREFRONTAL CORTEX AND ADOLESCENT BINGE DRINKING: ROLE OF HCN CHANNELS (Federal Gov)

    Feb 15 2015 - Jan 31 2021

    PREFRONTAL CORTEX AND ADOLESCENT BINGE DRINKING: ROLE OF HCN CHANNELS (Federal Gov)

    Feb 15 2015 - Jan 31 2020

    PREFRONTAL CORTEX AND ADOLESCENT BINGE DRINKING: ROLE OF HCN CHANNELS (Federal Gov)

    Feb 15 2015 - Jan 31 2020

    ALCOHOL ACTIONS-MOLECULAR TARGETS ON BRAIN PROTEINS (Federal Gov)

    Jun 1 2016 - May 31 2019

    IMPACT OF ADOLESCENT ALCOHOL ON DEVELOPMENT OF THE PREFRONTAL CORTEX (Federal Gov)

    Feb 1 2017 - Jan 31 2019

    HETEROGENEITY OF VTA DA NEURONS: RESPONSE TO ACUTE AND CHRONIC ETHANOL (Federal Gov)

    Aug 1 2015 - Jul 31 2018

    HETEROGENEITY OF VTA DA NEURONS: RESPONSE TO ACUTE AND CHRONIC ETHANOL (Federal Gov)

    Aug 1 2015 - Jul 31 2018

    FUNCTIONALLYSELECTIVE D2R S, STRIATAL CIRCUIT FUNCTION AND MOTIVATION (Federal Gov)

    May 20 2016 - Mar 31 2017

    MEDIUM SPINY NEURON EXCITABILITY AND MOTIVATION (Federal Gov)

    May 20 2011 - Sep 30 2016

    ALCOHOL WITHDRAWAL AND TONIC INHIBITION IN THE THALAMUS. (Federal Gov)

    Sep 16 2013 - Sep 15 2015

    ALCOHOL WITHDRAWAL AND TONIC INHIBITION IN THE THALAMUS. (Federal Gov)

    Sep 16 2013 - Jul 15 2015

    MECHANISMS OF ANESTHETIC EFFECTS ON TACHYKININ INDUCED AIRWAY TONE (Federal Gov)

    Jun 1 2011 - May 31 2015

    MECHANISMS OF ANESTHETIC EFFECTS ON TACHYKININ INDUCED AIRWAY TONE (Federal Gov)

    Jun 1 2011 - May 31 2015

    ALCOHOL AND DOPAMINE RELEASE: CELLULAR AND SYNAPTIC MECHANISMS (Federal Gov)

    Jul 15 2010 - Apr 30 2015

    ALCOHOL AND DOPAMINE RELEASE: CELLULAR AND SYNAPTIC MECHANISMS (Federal Gov)

    Jul 15 2010 - Apr 30 2015

    ALCOHOL AND INHIBITION IN THE PREFRONTAL CORTEX (Federal Gov)

    Sep 30 2012 - Sep 29 2014

    ETHANOL MODULATION OF GLYCINE RECEPTOR MEDIATED CURRENTS IN THE STRIATUM (Federal Gov)

    Sep 1 2013 - Apr 30 2014

    ALCOHOL AND GABA IN THE THALAMUS (Federal Gov)

    Apr 1 2007 - Mar 31 2012

    ALCOHOL,GILAL GENE EXPRESSION AND THE HEAT SHOCK PATHWAY (Federal Gov)

    Sep 30 2009 - Aug 31 2011

Publications

    Most recent work 2015-2021:

     

    Cabrera Garcia D., Miltiades A., Yim P., Parsons S., Elisman K., Mansouri M.T., Wagener G. and Harrison N.L. (2021) Plasma biomarkers associated with survival and thrombosis in hospitalized COVID-19 patients. 

    Medxiv https://doi.org/10.1101/2021.11.10.21266185

     

    Li M., Cabrera Garcia D., Salling M.C., Au E., Yang G. and Harrison N.L. (2021) 

    Alcohol reduces the activity of somatostatin interneurons in the mouse prefrontal cortex: a neural basis for its disinhibitory effect?

    Neuropharmacology, 188:108501

     

    Cabrera Garcia D., Bekdash R., Abbott G.W., Yazawa M. and Harrison N.L. (2021) 

    The envelope protein of SARS-CoV-2 increases intra-Golgi pH and forms a cation channel that is regulated by pH.

    Journal of Physiology, 599, 2851-2868.

     

    Wall A. and Harrison N.L. (2021) Early re-opening in New York this Spring would result in a resurgence of viral infections driven by the B1.1.7 variant of SARS-CoV-2. Medium. Feb 3, 2021.

    Cabrera Garcia D., Miltiades A., Parsons S., Elisman K., Mansouri M.T., Wagener G. and Harr N.L. (2021) 

    High levels of plasminogen activator inhibitor-1, tissue plasminogen activator and fibrinogen in patients with severe COVID-19. 

    MedRxiv 10.1101/2020.12.29.20248869

    Canetta S., Teboul E., Holt E., Bolkan S., Padilla N., Gordon J., Harrison N.L., and Kellendonk C. (2020) 

    Differential Synaptic dynamics and circuit connectivity of hippocampal and thalamic inputs to the prefrontal cortex. 

    Cerebral Cortex Communications, 1, tgaa084.

     

    Salling M.C. and Harrison N.L. (2020) 

    Constitutive genetic deletion of Hcn1 increases alcohol preference during adolescence.

    Brain Sciences, 10, 763.

     

    Salling M.C., Skelly M.J., Avegno E., Regan S., Zeric T., Nichols E. and Harrison N.L. (2018) 

    Alcohol consumption during adolescence in a mouse model of binge drinking alters the intrinsic excitability and function of the prefrontal cortex through a reduction in the hyperpolarization-activated cation current.

    Journal of Neuroscience,   

    McCracken L. Lowes D., Salling M.C., Vollmer C., Odean N., Betz H., Harris R.A. and Harrison N.L. (2017) 

    Glycine receptor α2 and α3 subunits mediate tonic and glycine-activated currents in brain.

    Proceedings of the National Academy of Sciences, 114, E7179 - E7184. 

     

    Harrison N.L., Skelly M.J., Grosserode E., Lowes D.C., Zeric T., Phister S. and Salling M.C. (2017)?

    Effects of acute alcohol on neuronal excitability in the CNS.

    Neuropharmacology, 122, 36-45.

     

    Yocum G.T., Turner D.L., Danielsson J., Barajas M.B., Zhang Y., Xu D., Harrison N.L., Homanics G.E., Farber D.L. and Emala C.W. (2017)?γ-Aminobutyric acid A receptor α4 subunit knockout enhances lung inflammation in a murine asthma model. 

    American Journal of Physiology, Lung, 313, L406-415.

    Avegno E., Salling M.C., Mrejeru A., Bjorklund A., Barnett A., Sulzer D. and Harrison N.L. (2016) 

    Adolescent drinking in mice enhances alcohol sensitivity of a subset of dopaminergic neurons in the ventral tegmental area. 

    Neuropharmacology, 110, 386-395.

     

    Canetta S., Bolkan S., Song L-J., Sahn R., Harrison N.L., Brown A. and Kellendonk C. (2016)

    Prenatal maternal immune activation alters prefrontal GABAergic transmission and anxiety-related behaviors in adult offspring.

    Molecular Psychiatry, 21, 956-968.

     

    Bekdash R. and Harrison N.L. (2015) 

    Down-regulation of Gabra4 expression during alcohol withdrawal is mediated by specific microRNAs in cultured mouse cortical neurons.

    Brain and Behavior, 5, e00355.

     

    Dixon C., Harrison N.L., Lynch J.W. and Keramidas A. (2015). 

    Zolpidem and eszopiclone prime α1β2γ2 GABAA receptors for longer duration of activity.

    British Journal of Pharmacology, 172, 3522-3536.

     

    Gallos G., Yocum G., Siviski M., Yim P., Fu X.W., Poe M., Cook J., Harrison N.L. and Emala C. (2015)

    Selective targeting of the α5 subunit of GABAA receptors relaxes airway smooth muscle and inhibits cellular calcium handling.

    American Journal of Physiology: Lung Cellular and Molecular Physiology, 308, L931-942.

     

    Mrejeru A., Avegno E., Marti-Prats L., Sulzer D. and Harrison N.L. (2015) 

    A subset of ventral tegmental area dopamine neurons responds to acute ethanol in naïve mice 

    Neuroscience, 290, 649-658.

     

    Coutts D.J. and Harrison N.L. (2015)

    Acetaldehyde, not ethanol, impairs myelin formation and viability in primary mouse oligodendrocytes.

    Alcohol: Clinical and Experimental Research, 39, 455-462.

     

    Gallo E., Salling M.C., Harrison N.L., Javitch J.A. and Kellendonk C. (2015)

    Upregulation of dopamine D2 receptors in the nucleus accumbens indirect pathway increases locomotion but does not reduce alcohol consumption.

    Neuropsychopharmacology, 40, 1609-1618.

    See more: https://scholar.google.com/citations?user=RfGMy94AAAAJ&hl=en

    For a complete list of publications, please visit PubMed.gov