Martin Picard, PhD

Academic Appointments

  • Associate Professor of Behavioral Medicine (in Psychiatry and Neurology)

Current Administrative Positions

  • Columbia Translational Neuroscience Initiative (CTNI) Scholar
Martin Picard, PhD

Martin Picard, PhD received his BSc Honours in neuroimmunology, and PhD in mitochondrial biology of aging at McGill University. He then moved to the University of Pennsylvania for a postdoctoral fellowship in the Center for Mitochondrial and Epigenomic Medicine with Doug Wallace. There, he worked on mitochondria-mitochondria interactions, mitochondrial reprogramming of the nuclear (epi)genome, and mitochondrial stress pathophysiology along with Bruce McEwen at the Rockefeller University. He joined the faculty of Columbia University in 2015.

Dr. Picard’s Mitochondrial PsychoBiology Laboratory investigates mechanisms of brain-body communication with a focus on mitochondria. Investigators and trainees in Dr. Picard’s translational research program combine clinical, cellular, and computational approaches to examine how psychosocial exposures impact mitochondrial structure and functions, and in turn, how energetic perturbations within mitochondria influence key brain-body processes involved in cognition, stress resilience, and aging.

Together with their collaborators, they work across organelle to organism to elucidate energetic principles that shape human health across the lifespan. Dr. Picard’s team has developed a mitochondrial health index (MHI) to study the mind-mitochondria connection, identified novel membrane structures for mitochondrial communication in humans, showed that cell-free mitochondrial DNA (cf-mtDNA) is a psychological stress-inducible molecule, developed a cellular lifespan model that recapitulates molecular longitudinal trajectories of human aging in vitro, and found that human hair greying is reversible and linked to life stress.

Laboratory website: www.picardlab.org

 

Departments and Divisions

  • Department of Neurology
    Division of Columbia Translational Neuroscience Initiative (CTNI)
  • Department of Psychiatry
    Division of Behavioral Medicine

Languages Spoken

  • French

Education and Training

  • PhD, 2012 Mitochondrial biology of aging, McGill University
  • Fellowship: 2015 University of Pennsylvania

Lab Locations

  • CUIMC/Presbyterian Hospital and Vanderbilt Clinic

    622 West 168th Street
    PH 1540 N
    New York, NY 10032
    Phone:
    (646) 774-8967
    Email:
    mp3484@columbia.edu
  • NYSPI-Kolb Research Building

    40 Haven Ave
    4th floor, Room 405
    New York, NY 10032
    Lab Phone:
    (646) 774-5026
    Email:
    mp3484@columbia.edu

Honors and Awards

  • 2015 Fellow, Gray Matters at Columbia
  • 2017 Research Fellow, Columbia University Aging Center
  • 2017 Herbert Irving Scholar, Columbia Irving Institute (2017-2020)
  • 2019 Neal E Miller New Investigator Award (ABMR)
  • 2019 NIH Rising Stars Lecture
  • 2021 Early Career Impact Award (Federation of Associations of Behavioral and Brain Sciences – FABBS)

Research Interests

  • Aging
  • Cell-free Mitochondrial DNA
  • Mitochondrial Disease
  • Mitochondrial Psychobiology
  • Mitochondrial Signaling and Behavior
  • Network Science
  • Stress Pathophysiology

NIH Grants

  • MITOCHONDRIAL REGULATION OF STRESS REACTIVITY IN HUMANS (Federal Gov)

    Apr 15 2020 - Mar 31 2025

    MINDFULNESS MEDITATION AND INSOMNIA IN ALZHEIMER DISEASE CAREGIVERS: INFLAMMATORY AND BIOLOGICAL AGING MECHANISM (Federal Gov)

    Sep 1 2017 - Jun 30 2022

    MITOCHONDRIAL STRESS SIGNAL TRANSDUCTION FROM ORGANELLE TO ORGANISM (Federal Gov)

    Sep 1 2016 - May 31 2021

    MITOCHONDRIAL REGULATION OF STRESS REACTIVITY IN HUMANS (Federal Gov)

    Jun 1 2017 - May 31 2019

Lab Projects

 Laboratory website: www.picardlab.org

Publications

Rausser S, Trumpff C, McGill MA, Wang W, Karan K, Mitchell A, Monk C, Segerstrom S, Reed R, Picard M. Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures. BioRxiv: https://www.biorxiv.org/content/10.1101/2020.10.16.342923v5

Rosenberg A, Rausser S, Ren J, Mosharov EV, Sturm G, Ogden RT, Patel P, Soni RK, Lacefield C, Tobin DJ, Paus R, Picard M. Quantitative mapping of human hair graying and reversal in relation to life stress. eLife 2021;10:e67437

Picard M, Sandi C. The social nature of mitochondria: Implications for human health. Neurosci Biobehav Rev 2021; 120(5):595-610

Karan KR, Trumpff C, McGill MA, Thomas JE, Sturm G, Lauriola V, Sloan RP, Rohleder N, Kaufman BK, Marsland AL, Picard M. Mitochondrial respiratory chain function modulates LPS-induced inflammatory signatures in human blood. Brain Behav Immun Health 2020; 100080

Picard M, Trumpff C, Burelle Y. Mitochondrial psychobiology: Foundation and applications. Curr Opin Behav Sci 2019; 28:142-151

Sturm G, Cardenas A, Bind MA, Horvath S, Wang S, Wang Y, Ha?gg S, Hirano M, Picard M. Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts. Epigenetics 2019; 14(10):961-976

Trumpff C, Marsland AL, Basualto C, Martin JL, Carroll JE, Sturm G, Gu Z, Vincent A, Kaufman BA, Picard M. Acute psychological stress increases serum circulating cell-free mitochondrial DNA. Psychoneuroendocrinol 2019; 106:268-276

Vincent AE, Turnbull DM, Hajnoczky G, Eisner V, Picard M. Mitochondrial nanotunnels. Trends Cell Biol 2017; 27(11):787-799

Picard M, McManus MJ, Gray J, Nasca C, Moffat C, Kopinsky P, Seifert E, McEwen BS, Wallace DC. Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory and transcriptional responses to psychological stress. PNAS 2015; 112(48):E6614-23

For a complete list of publications, please visit PubMed.gov