Jay Gingrich, MD, PhD

Academic Appointments

  • Sackler Institute Professor of Developmental Psychology (in Psychiatry) at the Columbia University Medical Center
Jay Gingrich, MD, PhD
The mouse represents the most tractable experimental model of vertebrate behavior and brain function currently available. We use genetic, pharmacologic, environmental, and other manipulations to probe mechanisms underlying normal and abnormal behaviors that have relevance to neuropsychiatry. Current projects examine the role of serotonin in brain development, the role of serotonin signaling in anxiety, depression, and psychosis; the epigenetics of complex disorders such as autism and schizophrenia, and the biological basis of environmental effects on genetic vulnerabilities to behavioral abnormalities. The mouse and the powerful techniques that can be applied to its study offer the capacity go beyond correlation and establish causality in our quest to understand how the brain affects behavior.

The mouse represents the most tractable experimental model of vertebrate behavior and brain function currently available. We use genetic, pharmacologic, environmental, and other manipulations to probe mechanisms underlying normal and abnormal behaviors that have relevance to neuropsychiatry. Current projects examine the role of serotonin in brain development, the role of serotonin signaling in anxiety, depression, and psychosis; the epigenetics of complex disorders such as autism and schizophrenia, and the biological basis of environmental effects on genetic vulnerabilities to behavioral abnormalities. The mouse and the powerful techniques that can be applied to its study offer the capacity go beyond correlation and establish causality in our quest to understand how the brain affects behavior.

Departments and Divisions

  • Department of Psychiatry
    Division of Developmental Neuroscience

Lab Locations

  • CUIMC/Herbert Pardes Building of the New York State Psychiatric Institute

    1051 Riverside Drive
    Unit 40
    New York, NY 10032
    Phone:
    (646) 774-6252
    Email:
    jag46@cumc.columbia.edu

Research Interests

  • Cognitive/Systems Neuroscience
  • Depression, Anxiety, Schizophrenia
  • Models of Psychiatric Disorders
  • Neurobiology of Disease
  • Neurogenetics
  • Treatment of Psychiatric Disorders in Pregnancy
  • Treatment Resistance

NIH Grants

  • SERATONERGICMODULATION OF BRAIN DEVELOPMENT: GENETIC AND PHARMACOLOGIC INFLUENCES ON STRUCTURE, FUNCTION, AND BEHAVIOR (Federal Gov)

    Sep 1 2010 - May 31 2015

    DEVELOPMENTAL ROLE OF NEUREGULIN-1 IN SUBVENTRICULAR ZONE STEM CELL FATE (Federal Gov)

    Sep 15 2011 - Sep 14 2014

    MODELING SCHIZOPHRENIA IN MICE BY ALTERED DEVELOPMENTAL EXPRESSION OF NEUREGULIN 1 (Private)

    Jul 15 2011 - Jul 14 2014

    PIRNA-DIRECTED DNA METHYLATION IN ADVANCED PATERNAL AGE AND OFFSPRING PSYCHIATRIC DISORDERS (Private)

    Jul 15 2011 - Jul 14 2013

    POSTNATAL SSRI TREATMENT: EFFECTS ON SEROTONERGIC PROJECTION S AND GENE EXPRESSION (Federal Gov)

    Dec 1 2009 - Nov 30 2012

    POSTNATAL SSRI TREATMENT: EFFECTS ON SEROTONERGIC PROJECTIONS AND GENE EXPRESSION (Federal Gov)

    Dec 1 2009 - May 31 2012

    MODELING SCHIZOPHRENIA IN MICE BY ALTERED DEVELOPMENTAL EXPR ESSION OF NEUREGULIN 1 (Private)

    Jul 1 2008 - Jun 30 2011

    NEURAL SUBSTRATES OF 5-HT2A RECEPTOR-MEDICATED HALLICINOGENESIS (Private)

    Jan 1 2005 - Dec 31 2007

Publications

1: Gingrich JA, Malm H, Ansorge MS, Brown A, Sourander A, Suri D, Teixeira CM,Caffrey Cagliostro MK, Mahadevia D, Weissman MM. New Insights into How SerotoninSelective Reuptake Inhibitors Shape the Developing Brain. Birth Defects Res.2017 Jul 17;109(12):924-932.

2: Lugo-Candelas C, Cha J, Hong S, Bastidas V, Weissman M, Fifer WP, Myers M,Talati A, Bansal R, Peterson BS, Monk C, Gingrich JA, Posner J. AssociationsBetween Brain Structure and Connectivity in Infants and Exposure to SelectiveSerotonin Reuptake Inhibitors During Pregnancy. JAMA Pediatr. 2018 Jun1;172(6):525-533

3: Grieve PG, Fifer WP, Cousy NP, Monk CE, Stark RI, Gingrich JA, Myers MM.Neonatal infant EEG bursts are altered by prenatal maternal depression andserotonin selective reuptake inhibitor use. Clin Neurophysiol. 2019Nov;130(11):2019-2025.

4: Brown AS, Gyllenberg D, Malm H, McKeague IW, Hinkka-Yli-Salomäki S, Artama M,Gissler M, Cheslack-Postava K, Weissman MM, Gingrich JA, Sourander A.Association of Selective Serotonin Reuptake Inhibitor Exposure During PregnancyWith Speech, Scholastic, and Motor Disorders in Offspring. JAMA Psychiatry. 2016Nov 1;73(11):1163-1170.

5: Malm H, Brown AS, Gissler M, Gyllenberg D, Hinkka-Yli-Salomäki S, McKeagueIW, Weissman M, Wickramaratne P, Artama M, Gingrich JA, Sourander A. GestationalExposure to Selective Serotonin Reuptake Inhibitors and Offspring PsychiatricDisorders: A National Register-Based Study. J Am Acad Child Adolesc Psychiatry.2016 May;55(5):359-66

6: McOmish CE, Demireva EY, Gingrich JA. Developmental expression of mGlu2 andmGlu3 in the mouse brain. Gene Expr Patterns. 2016 Nov;22(2):46-53.