Jean Gautier, PhD

Academic Appointments

  • Professor of Genetics and Development (in the Institute for Cancer Genetics)

Current Administrative Positions

  • Leader, Cancer Genomics and Epigenomics Program, Herbert Irving Comprehensive Cancer Center
Jean Gautier, PhD

Email: jg130@cumc.columbia.edu

Jean Gautier studies the mechanisms responsible for the maintenance of genome stability. The laboratory employs diverse experimental approaches to elucidate the causes and the role of genome instability in cancer. Cell-free extracts derived from the egg of the frog Xenopus laevis are used as a simple model system to study processes that govern genome stability, including DNA replication control, DNA repair, and the cellular response to DNA damage. In addition, cultured normal and tumor cells and mouse models are exploited to analyze biological responses to DNA damage. The Gautier laboratory use a range of techniques including biochemistry, proteomics, live-cell imaging, super-resolution microscopy, Hi-C and genome-wide translocation sequencing.

Departments and Divisions

  • Department of Genetics & Development

Centers / Institutes / Programs

  • Herbert Irving Comprehensive Cancer Center

Lab Locations

  • Irving Cancer Research Center

    1130 St. Nicholas Avenue
    602
    New York, NY 10032
    Lab Phone:
    (212) 851-4566
    Fax:
    (212) 851-5256
    Email:
    sv2490@cumc.columbia.edu

NIH Grants

  • DNADOUBLE-STRAND BREAK REPAIR, CHROMOSOME TRANSLOCATIONS AND CANCER (Federal Gov)

    Apr 1 2020 - Mar 25 2025

    MULTISCALE PROTEOMICS STUDIES OF DNA REPAIR AND GENOMIC STABILITY (Federal Gov)

    Sep 1 2018 - Aug 31 2023

    HOMOLOGOUS RECOMBINATION REPAIR DOMAINS: FORMATION AND IMPACT ON GENOME STABILITY (Federal Gov)

    Jul 1 2020 - Jun 30 2023

    DNA REPAIR AND GENOMIC INSTABILITY IN CANCER DEVELOPMENT AND THERAPY (Federal Gov)

    Aug 1 2015 - Jul 31 2022

    DNA REPAIR AND GENOMIC INSTABILITY IN CANCER DEVELOPMENT AND THERAPY (Federal Gov)

    Aug 1 2015 - Jul 31 2022

    ROLE OF NUCLEAR ACTIN POLYMERIZATION IN DOUBLE-STRAND BREAK MOBILITY AND REPAIR (Federal Gov)

    Mar 1 2018 - Feb 28 2021

    DNA DOUBLE-STRAND BREAK REPAIR, CHROMOSOMES TRANSLOCATIONS AND CANCER (Federal Gov)

    Apr 1 2014 - Mar 31 2020

    CANCER CENTER SUPPORT GRANT (Federal Gov)

    Jul 1 2014 - Jun 30 2019

    CANCER CENTER SUPPORT GRANT (Federal Gov)

    Jul 1 2014 - Jun 30 2019

    CANCER CENTER SUPPORT GRANT (Federal Gov)

    Jul 1 2014 - Jun 30 2019

    DNA DOUBLE-STRAND BREAD REPAIR, CHROMOSOME TRANSLOCATIONS AND CANCER (Federal Gov)

    Apr 1 2014 - Mar 31 2019

    DNA DOUBLE-STRAND BREAD REPAIR, CHROMOSOME TRANSLOCATIONS AND CANCER (Federal Gov)

    Apr 1 2014 - Mar 31 2019

    REGULATION FOR THE DNA DAMAGE RESPONSE BY THE ATM-MRN PATHWAY (Federal Gov)

    Jul 1 2001 - May 31 2018

    REGULATION FOR THE DNA DAMAGE RESPONSE BY THE ATM-MRN PATHWAY (Federal Gov)

    Jul 1 2001 - May 31 2018

    CANCER BIOLOGY TRAINING GRANT (Federal Gov)

    Sep 1 1984 - Aug 31 2017

    STUDIES OF DNA INTERSTRAND CROSSLINK REPAIR TO IMPROVE CROSSLINKING DRUG THERAPIES (Federal Gov)

    Jul 18 2012 - Apr 30 2017

    STUDIES OF DNA INTERSTRAND CROSSLINK REPAIR TO IMPROVE CROSSLINKING DRUG THERAPIES (Federal Gov)

    Jul 18 2012 - Apr 30 2017

    REGULATION OF DNA REPUBLICATION BY MCM PROTEINS (Federal Gov)

    Apr 1 2008 - Mar 31 2013

    MYC-DEPENDENT DNA REPLICATION STRESS AND BREAST CANCER (Federal Gov)

    Jul 15 2009 - Jul 14 2012

    EVALUATING INTERSTRAND CROSSLINK (ICL) REPAIR IN TRIPLE NEGA TIVE BREAST CANCERS TO GUIDE CHEMOTHERAPY (Federal Gov)

    Apr 1 2011 - Apr 30 2012

    COORDINATION OF BRCA1/BARD1 AND MRE11/RAD50/NBS1 DEPENDENT D NA TRANSACTIONS IN BREAST TUMOR SUPPRESS (Federal Gov)

    Jul 1 2008 - Jun 30 2011

Lab Members

  • Mai Sato, Post-doctoral Fellow
  • Benjamin Schrank, MD/PhD Student
  • Gaganpreet Sidhu, Post-doctoral Fellow
  • Tao Yu, Post-doctoral Fellow
  • Soumini Vasan, Laboratory Manager
  • Tomas Aparicio, Research Associate
  • Crystal Waters, Post-doctoral Fellow
  • Niyo Kato, Graduate Student
  • Andrew Liebau, Graduate Student

Publications

  1. Dual-Color Plasmonic Nanosensor for Radiation Dosimetry
    Tao Y, Li M, Liu X, Leong KW, Gautier J, Zha S
    ACS Appl Mater Interfaces. 2020.
    PMID: 32337977, DOI: 10.1021/acsami.0c03001
  2. Assembling nuclear domains: Lessons from DNA repair
    Schrank B, Gautier J
    J Cell Biol. 2019.
    PMID: 31324649, DOI: 10.1083/jcb.201904202
  3. Nuclear ARP2/3 drives DNA break clustering for homology-directed repair
    Schrank BR, Aparicio T, Li Y, Chang W, Chait BT, Gundersen GG, Gottesman ME, Gautier J
    Nature. 2018.
    PMID: 29925947, DOI: 10.1038/s41586-018-0237-5
  4. Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway
    Kato N, Kawasoe Y, Williams H, Coates E, Roy U, Shi Y, Beese LS, Schärer OD, Yan H, Gottesman ME, Takahashi TS, Gautier J
    Cell Rep. 2017.
    PMID: 29091773, DOI: 10.1016/j.celrep.2017.10.032
  5. MRN, CtIP, and BRCA1 mediate repair of topoisomerase II-DNA adducts
    Aparicio T, Baer R, Gottesman M, Gautier J
    J Cell Biol. 2016.
    PMID: 26880199, DOI: 10.1083/jcb.201504005
  6. MYC is a critical target of FBXW7
    Sato M, Rodriguez-Barrueco R, Yu J, Do C, Silva JM, Gautier J
    Oncotarget. 2015.
    PMID: 25669969, DOI: 10.18632/oncotarget.3203
  7. Cdc45 is a critical effector of myc-dependent DNA replication stress
    Srinivasan SV, Dominguez-Sola D, Wang LC, Hyrien O, Gautier J
    Cell Rep. 2013.
    PMID: 23643534, DOI: 10.1016/j.celrep.2013.04.002
  8. Activation of DSB processing requires phosphorylation of CtIP by ATR
    Peterson SE, Li Y, Wu-Baer F, Chait BT, Baer R, Yan H, Gottesman ME, Gautier J
    Mol Cell. 2013.
    PMID: 23273981, DOI: 10.1016/j.molcel.2012.11.020
  9. Replication-independent repair of DNA interstrand crosslinks
    Williams HL, Gottesman ME, Gautier J
    Mol Cell. 2012.
    PMID: 22658724, DOI: 10.1016/j.molcel.2012.05.001
  10. Double-strand break end resection and repair pathway choice
    Symington LS, Gautier J
    Annu Rev Genet. 2011.
    PMID: 21910633, DOI: 10.1146/annurev-genet-110410-132435
  11. Checkpoint signaling from a single DNA interstrand crosslink
    Ben-Yehoyada M, Wang LC, Kozekov ID, Rizzo CJ, Gottesman ME, Gautier J
    Mol Cell. 2009.
    PMID: 19748363, DOI: 10.1016/j.molcel.2009.08.014
  12. A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex
    Dupré A, Boyer-Chatenet L, Sattler RM, Modi AP, Lee JH, Nicolette ML, Kopelovich L, Jasin M, Baer R, Paull TT, Gautier J
    Nat Chem Biol. 2008.
    PMID: 18176557, DOI: 10.1038/nchembio.63
  13. Non-transcriptional control of DNA replication by c-Myc
    Dominguez-Sola D, Ying CY, Grandori C, Ruggiero L, Chen B, Li M, Galloway DA, Gu W, Gautier J, Dalla-Favera R
    Nature. 2007.
    PMID: 17597761, DOI: 10.1038/nature05953
  14. ATR and ATM regulate the timing of DNA replication origin firing
    Shechter D, Costanzo V, Gautier J
    Nat Cell Biol. 2004.
    PMID: 15220931, DOI: 10.1038/ncb1145
  15. An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication
    Costanzo V, Shechter D, Lupardus PJ, Cimprich KA, Gottesman M, Gautier J
    Mol Cell. 2003.
    PMID: 12535533, DOI: 10.1016/s1097-2765(02)00799-2

For a complete list of publications, please visit PubMed.gov