Gerard Karsenty, MD, PhD

Academic Appointments

  • Paul A. Marks Professor of Genetics and Development
  • Professor of Medicine

Current Administrative Positions

  • Chair, Genetics and Development Department
Gerard Karsenty, MD, PhD

Gerard Karsenty M.D., Ph.D., is the Paul A. Marks M.D., Professor and Chair of the Department of Genetics and Development at Columbia University Medical center, New York City. In the last 20 years, his laboratory has studied every aspect of skeletal biology ranging from development to physiology. His laboratory deciphered the molecular bases of osteoblast-specific gene expression, a work that culminated in his identification of Runx2 as the master gene of osteoblast differentiation. This was followed by the identification of an entire cascade of transcription factors regulating osteoblast differentiation and of Gcm2 as the master gene of parathyroid gland development. In approaching bone physiology Karsenty proposed that there is a coordinated control endocrine in nature, of bone mass, energy metabolism and fertility. The Karsenty lab has verified in the mouse and whenever possible in humans all tenets of this hypothesis. One of them is that bone should be an endocrine organ regulating energy metabolism and reproduction. This led to the identification of osteocalcin as a bone-derived hormone needed for insulin secretion, glucose homeostasis, testosterone secretion by Leydig cells of the testes and male fertility, brain development cognition and adaptation to exercise. Currently his work focuses through the definition of all functions of osteocalcin in understanding why would bone be an endocrine organ.

Genetics to understand Development, Physiology and Pathogenesis of all diseases

Departments and Divisions

  • Department of Medicine
    Division of Endocrinology
  • Department of Genetics & Development

Languages Spoken

  • French

Education and Training

  • MD, PhD, Physiology, Paris Medical School, France
  • Fellowship: MD Anderson Cancer Center
  • Fellowship: National Institute of Health

Centers / Institutes / Programs

  • Institute of Human Nutrition
  • Herbert Irving Comprehensive Cancer Center

Lab Locations

  • Hammer Health Sciences Building

    701 West 168th Street
    New York, NY 10032
    Lab Phone:
    (212) 305-9586
    Fax:
    (212) 923-2090
    Email:
    hl2155@cumc.columbia.edu

Contact Info

  • (212) 305-4011

Past Positions

1987-1988 Postdoctoral Fellow, Molecular Genetics, M.D. Anderson Cancer Center, Houston, TX

1988-1990 Research Associate, Molecular Genetics, M.D. Anderson Cancer Center, Houston, TX

1990-1995 Assistant Professor, Molecular Genetics, M.D. Anderson Cancer Center, Houston, TX

1996-1997 Associate Professor, Molecular Genetics, M.D. Anderson Cancer Center, Houston, TX

1998-1999 Associate Professor, Molecular and Human Genetics, Baylor College of Medicine, Houston, TX

1999-2006 Professor, Molecular and Human Genetics, Baylor College of Medicine, Houston, TX

2006-Present Professor and Chair, Department of Genetics and Development, College of Physicians and Surgeons, Columbia University Medical Center

Committees / Societies / Memberships

1991-present American Society of Biological Chemistry

1991-present American Society of Bone and Mineral Research

1995-present American Endocrine Society

2002-present International Society of Matrix Biology

2003-present Member of the IBMS Board of Directors

2006-present Member of Association of American Physicians

2008-present Member of The American Physiological Society

2015-present Member of National Academy of Medicine

2014-present Member of The New York Academy of Sciences

2015-present Member of American Society of Microbiology

2017-present Member of the NOF Ambassadors Leadership Council

2017-present Elected Associate Member of EMBO

Honors and Awards

2017: Elected Associate Member of EMBO

2017: The AACE Frontiers in Science Award

2016: Steven's Triennial Prize for Excellence in Original Medical Research

2016: Roy E. Greep Award for Excellence in Basic Science, the Endocrine Society

2014: Member National Academy of Medicine

2012: Hoffenberg International Medal British Endocrine Society

2011: ASBMR William F. Neuman Award

2011: Herbert Fleisch Achievement Award in Basic Science, IOF

2011: Senior Scholar in Aging Ellison Foundation

2010: Jacobaeus Prize NovoNordisk Foundation, Denmark

2010: Member, College of CSR Reviewers, NIH

2010: Richard Lounsbery Award, National Academy of Science (USA), Academie des Sciences (France)

2008: Lee C. Howley Prize for Arthritis Research, Arthritis Foundation

2007: Schaefer Award, Columbia University Medical Center

2007: Drieu-Cholet Award, The French National Academy of Medicine

2006: Edith and Peter O’Donnell Award, The Academy of Medicine, Engineering and Science of Texas

2002: Member of The Association of American Physicians

2001: Louis V. Avioli Founders Award of the ASBMR

2001: D. Harold Copp Award of the IBMS

2000: Michael E. De Bakey Excellence in Science Award

1997: Research Award of the Austrian Bone and Mineral Research Society

1996: International Bone and Calcium Institute Young Scientist Award

1985: French Endocrine Society Award for Young Scientists

NIH Grants

  • MUSCLE REGULATION OF BONE FUNCTION (Federal Gov)

    Apr 1 2019 - Feb 28 2024

    A NEURONAL BASIS FOR THE OSTEOCALCIN REGULATION OF BONE MASS (Federal Gov)

    Aug 15 2018 - Jul 31 2023

    REGULATION OF ADRENAL STEROIDOGENESIS BY THE SKELETON (Private)

    Jun 1 2018 - May 31 2021

    THE DIALOGUE BETWEEN BONE AND THE BRAIN: ENDOCRINE AND MOLECULAR BASES (Federal Gov)

    Jun 1 2015 - Apr 30 2021

    REGULATION OF GLUCOSE UPTAKE IN OSTEOBLASTS BY RUNX2 (Federal Gov)

    Sep 1 2015 - Jun 30 2020

    REGULATION OF GLUCOSE UPTAKE IN OSTEOBLASTS BY RUNX2 (Federal Gov)

    Sep 24 2015 - Jun 30 2020

    THE DIALOGUE BETWEEN BONE AND THE BRAIN: ENDOCRINE AND MOLECULAR BASES (Federal Gov)

    Aug 1 2015 - Apr 30 2020

    THE DIALOGUE BETWEEN BONE AND THE BRAIN: ENDOCRINE AND MOLECULAR BASES (Federal Gov)

    Aug 1 2010 - Apr 30 2020

    KERENTHERAPEUTICS, INC. (Private)

    Feb 6 2018 - Feb 5 2019

    INNOVATIONS IN PROSTATE CANCER (Federal Gov)

    Nov 1 2015 - Oct 31 2017

    CHARACTERIZATION OF A RECEPTOR MEDIATING ADIPONECTIN FUNCTIONS ON BONE (Federal Gov)

    Sep 15 2015 - Aug 31 2016

    MOLECULAR BASES OF THE ANTI-AGING FUNCTIONS OF THE BONE DERIVED HORMONE OSTEOCALCIN (Private)

    Nov 1 2011 - Oct 31 2015

    MOLECULAR MEDIATORS OF GROUP B STREPTOCOCCAL CHORIOAMNIONITIS AND VERTICAL TRANSMISSION (Federal Gov)

    Jul 1 2014 - Jun 30 2015

    OSTEOCALCIN: THE HORMONAL LINK BETWEEN BONE AND REPRODUCTION (Federal Gov)

    Jul 1 2010 - Jun 30 2015

    LRP5-DEPENDENT REGULATION OF BONE MASS ACCRUAL BY GUT-DERIVED SEROTONIN (Federal Gov)

    Jul 1 2009 - May 31 2014

    SEROTONIN IN WHOLE BODY ENERGY METABOLISM (Private)

    May 4 2012 - May 3 2014

    OSTEOCALCIN AS A MULTIFUNCTIONAL HORMONE (Private)

    Feb 18 2011 - Feb 17 2014

    REGULATION OF GLUCOSE METABOLISM BY BONE RESORPTION (Private)

    Jul 1 2011 - Jun 30 2013

    OSTEOCALCIN AS A REGULATOR OF ENERGY METABOLISM (Federal Gov)

    Apr 1 1998 - Apr 30 2013

    THE FIAT-AFF4 INTERACTION AND THE CONTROL OF BONE MASS (Federal Gov)

    Aug 1 2006 - Jul 31 2011

    LEPTIN AS A REGULAR OF BONE MASS (Federal Gov)

    May 1 2006 - Jun 30 2011

    GUT - DERIVED SEROTONIN AS A MEDIATOR OF IRP5 REGULATION OF BONE MASS (Private)

    Jul 1 2006 - May 31 2011

    REGULATION OF ENERGY METABOLISM BY AN OSTEOBLAST-SPECIFIC GE NE (Federal Gov)

    May 5 2007 - Apr 30 2011

Lab Members

  • Subrata Chowdhury, Postdoctoral Research Fellow
  • Junhee Park, Postdoctoral Research Fellow
  • Hong Liu, Lab Manager
  • Julian Meyer Berger, Student, Graduate School of Arts and Sciences
  • Vijay Yadav, Research Scientist
  • Biagio Palmisano, Postdoctoral Research Scientist

Publications

1: Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G. Endocrine regulation of energy metabolism by the skeleton. Cell. 2007 130(3):456-69.

2: Oury F, Sumara G, Sumara O, Ferron M, Chang H, Smith CE, Hermo L, Suarez S, Roth BL, Ducy P, Karsenty G. Endocrine regulation of male fertility by the skeleton. Cell. 2011 144(5): 796-809.

3: Oury F, Khrimian L, Denny CA, Gardin A, Chamouni A, Goeden N, Huang YY, Lee H, Srinivas P, Gao XB, Suyama S, Langer T, Mann JJ, Horvath TL, Bonnin A, Karsenty, G. Maternal and offspring pools of osteocalcin influence brain development and functions. Cell. 2013 155(1): 228-41.

4: Wei J, Shimazu J, Makinistoglu M, Maurizi A, Kajimura D, Zong H, Takarada T, Iezaki T, Pessin JE, Hinoi E, and Karsenty G. Glucose uptake and Runx2 synergize to orchestrate osteoblast differentiation and bone formation. Cell. 2015 161(7): 1576-91.

5: Mera P, Laue K, Ferron M, Confavreux C, Wei J, Galan-Diez M, Lacampagne A, Mitchell SJ, Mattison JA, Chen Y, Bacchetta J, Szulc P, Kitsis RN, de Cabo R, Friedman RA, Torsitano C, McGraw TE, Puchowicz M, Kurland I and Karsenty G. Osteocalcin signaling in myofibers is necessary and sufficient for optimum adaptation to exercise. Cell Metab. 2016 23(6):1078-92.

6: Berger JM, Singh P, Khrimian L, Morgan DA, Chowdhury S, Arteaga-Solis E, Horvath TL, Domingos AI, Marsland AL, Yadav VK, Rahmouni K, Gao XB and Karsenty G. Mediation of the acute stress response by the skeleton. Cell Metab. 2019 30(5): 890-902

For a complete list of publications, please visit PubMed.gov