Franklin D. Lowy, MD

Academic Appointments

  • Professor of Medicine at CUMC
  • Professor of Pathology & Cell Biology at CUMC
Franklin D. Lowy, MD

Dr Franklin Lowy is the Clyde '56 and Helen Wu professor of medicine and pathology & cell biology (in epidemiology) in the Division of Infectious Diseases in the College of Physicians and Surgeons at Columbia University. His laboratory investigates the pathogenesis and epidemiology of Staphylococcus aureus and Staphylococcus epidermidis infections.

Email: fl189@cumc.columbia.edu

Dr. Franklin Lowy’s laboratory investigates the pathogenesis and epidemiology of Staphylococcus aureus and Staphylococcus epidermidis infections.

Departments and Divisions

  • Department of Medicine
    Division of Infectious Diseases
  • Department of Pathology & Cell Biology

Board Certifications

  • Internal Medicine
  • Infectious Disease

Areas of Expertise

  • Bacterial Infection
  • MRSA (Methicillin Resistant Staphylococcus Aureus) Infection
  • Staphylococcal Infection

Education and Training

  • Columbia University College of Physicians and Surgeons
  • Internship: Harlem Hospital Center
  • Residency: Harlem Hospital Center
  • Fellowship: Albert Einstein Medical Center

Locations

  • CUIMC/Harkness Pavilion

    180 Fort Washington Avenue
    2-242
    New York, NY 10032
    For new and current patient appointments, call:
    (212) 305-8039
    Phone:
    (212) 305-8039
    Fax:
    (212) 305-1754

Provider Affiliations

  • NewYork-Presbyterian / Columbia University Irving Medical Center

Insurance Programs

Please contact the provider's office directly to verify that your particular insurance is accepted.

  • AETNA [Aetna Signature Administrators, EPO, HMO, Medicare Managed Care, NYP Employee Plan, NY Signature, POS, PPO, Student Health]
  • Affinity Health Plan [Essential Plan, Medicaid Managed Care]
  • AgeWell [Medicare Managed Care, Special Needs]
  • Amida Care [Special Needs]
  • CIGNA [EPO, Great West (National), HMO, POS, PPO]
  • Emblem/GHI [Medicare Managed Care, PPO]
  • Emblem/HIP [ConnectiCare, EPO, Essential Plan, HMO, Medicaid Managed Care, Medicare Managed Care, POS, PPO, Select Care (Exchange), Vytra]
  • Empire Blue Cross/Blue Shield [EPO, HMO, Medicare Managed Care, PPO]
  • Empire Blue Cross Blue Shield HealthPlus [Child/Family Health Plus, Essential Plan, Medicaid Managed Care]
  • Fidelis Care [Child/Family Health Plus, Essential Plan, Medicaid Managed Care, Medicare Managed Care]
  • Healthfirst [Child/Family Health Plus, Leaf (Exchange), Medicaid Managed Care, Medicare Managed Care]
  • Local 1199 [Local 1199]
  • MagnaCare (National) [MagnaCare]
  • Medicare [Railroad, Traditional Medicare]
  • Multiplan [Multiplan]
  • MVP Health Care [Child/Family Health Plus, Essential Plan, HMO, Medicaid Managed Care]
  • Oxford Health Plans [Freedom, Liberty]
  • Quality Health Management [Quality Health Management]
  • RiverSpring [Special Needs]
  • UnitedHealthcare [Columbia University Employee Plan, Compass (Exchange), Empire Plan, HMO, Medicaid (Community Plan), Medicare Managed Care, POS, PPO]
  • VNSNY CHOICE [Medicare Managed Care, SelectHealth, Special Needs]
  • WellCare [Medicaid Managed Care, Medicare Managed Care]

This provider does not accept new patients

Lab Locations

  • CUIMC/Harkness Pavilion

    180 Fort Washington Avenue
    2-242
    New York, NY 10032

Contact Info

  • (212) 305-8039

NIH Grants

  • THE MOLECULAR EPIDEMIOLOGY OF STAPHYLOCOCCUS AUREUS BACTEREMIAS DURING THE OPIOID EPIDEMIC: A NEW YORK REGION PERSPECTIVE (Federal Gov)

    Mar 9 2020 - Feb 28 2022

    TOPICAL VANCOMYCIN FOR CRANIOTOMY WOUND PROPHYLAXIS (Federal Gov)

    Jul 1 2014 - Jun 30 2020

    TOPICAL VANCOMYCIN FOR CRANIOTOMY WOUND PROPHYLAXIS (Federal Gov)

    Jul 1 2014 - Jun 30 2019

    TOPICAL VANCOMYCIN FOR CRANIOTOMY WOUND PROPHYLAXIS (Federal Gov)

    Jul 1 2014 - Jun 30 2019

    EFFICACY OF TELAVANCIN COMPARED WITH OTHER ANTIMICROBILAS IN THE TREATMENT OF OSTEOMYELITIS DUE TO MRSA AND VISA STRAINS OF STAPHYLOCOCCUS AUREUS (Private)

    Aug 7 2015 - Aug 7 2016

    RISK FACTORS FOR SPREAD OF STAPHYLOCOCCUS AUREUS IN PRISONS. (Federal Gov)

    Aug 15 2009 - Jul 31 2015

    THE USE OF WHOLE GENOME SEQUENCING TO IDENTIFY SPREAD OF USA300 IN THE COMMUNITY (Federal Gov)

    Feb 11 2013 - Jan 31 2015

    THE USE OF WHOLE GENOME SEQUENCING TO IDENTIFY SPREAD OF USA300 IN THE COMMUNITY (Federal Gov)

    Feb 11 2013 - Jan 31 2015

    THE USE OF WHOLE GENOME SEQUENCING TO IDENTIFY SPREAD OF USA300 IN THE COMMUNITY (Federal Gov)

    Feb 11 2013 - Jan 31 2015

    MODELING OF S. AUREUS TRANSMISSION IN NORTHERN MANHATTAN (Federal Gov)

    Dec 15 2008 - Nov 30 2014

    MODELING OF S. AUREUS TRANSMISSION IN NORTHERN MANHATTAN (Federal Gov)

    Apr 1 2008 - May 31 2012

    MODELING OF S. AUREUS TRANSMISSION IN NORTHERN MANHATTAN (Federal Gov)

    Apr 1 2008 - May 31 2012

    THE BIOLOGY OF HUMAN LONG-TERM MECHANICAL CIRCULATORY SUPPOR T (Federal Gov)

    Feb 25 2005 - Dec 31 2011

    IN VITRO AN IN VIVO EVALUATING THE EFFICACY OF DAPTOMYCIN AL ONE AND IN COMBINATION WITH OTHER ANTIMICROBIALS IN THE TREA (Private)

    Nov 15 2006 - Nov 30 2011

    MECHANISMS OF STAPHYLOCOCCUS AUREUS VANCOMYCIN RESISTANCE (Private)

    Sep 15 2009 - Aug 1 2011

Lab Projects

  • Studies on the pathogenesis of staphylococcal infections
    Recent projects have focused on the role of different S. aureus and S. epidermidis surface proteins as mediators of adherence to explanted left ventricular assist device (LVAD) material. The goal of these studies has been to characterize the role of these proteins in the initiation of device-related infections. A second series of studies have used a mouse post-influenza model for S. aureus pneumonia to investigate the pathogenesis of these life-threatening infections.

  • Studies on the transmission of S. aureus among high-risk populations

    A household-based study is underway to investigate how CA-MRSA is spread in the predominantly Dominican population that surrounds Columbia University Medical Center. Genetic characterization of these isolates as they spread within the community will examine whether adaptive changes facilitate spread. The goal of these studies is to gain a better understanding of the factors that contribute to the dissemination of S. aureus within this population. A second component of this investigation is to examine the spread of a unique methicillin-susceptible S. aureus, strain ST398. This strain is prevalent in Northern Manhattan and is responsible for an increasing number of clinical infections. A second transmission study is underway to determine how CA-MRSA strains are introduced and spread into the NYS prison system. The study, performed at Sing Sing and Bedford Hills maximum-security prisons examines inmates at entry, during their stay and at release from the two prisons. Molecular epidemiologic techniques are used to characterize the predominant isolates in the two facilities.

    A different transmission study examined how CA-MRSA strains are introduced into and spread within the NYS prison system. The study examined the clonal nature of infections in the prison system, their source and the impact of inmate movement on the dissemination of these unique clones of S. aureus. Molecular epidemiologic techniques were used to characterize the predominant isolates in the two facilities. The role of inmate transfer on the spread of these epidemic strains was also examined.

    A new project is using a genomic approach to map the distribution of antimicrobial resistance genes in different New York City neighborhoods. The ultimate goal is to create a New York City map of the distribution of antibiotic resistance genes and then use this to identify risks that contribute to high resistance levels in different geographic areas of the city.

Lab Members

  • Frank D. Lowy, MD
  • Rachel J. Gordon, MPH, MD
  • Anne-Catrin Uhlemann, MD, Ph.D

Publications

Lowy, F.D. Staphylococcal Infections In: Harrison's Principles of Internal Medicine, 20th edition. Editors: D. L. Longo, A. S. Fauci, D.L. Kasper, S. L. Hauser, J. L. Jameson andJ.Loscalzo. The McGraw- Hill Companies, Inc., In Press 2017.

Befus MB, Miko BA, Herzig CT, Keleekai N, Mukherjee DV, Larson E, Lowy F.D. HIV and colonization with Staphylococcus aureus in two maximum-security prisons in New York State. J Infect. 2016 Sep 1. pii: S0163-4453(16)30220-1. doi: 10.1016/j.jinf.2016.08.016. [Epub ahead of print]

Knox J, Sullivan SB, Urena J, Miller M, Vavagiakis P, Shi Q, Uhlemann AC, Lowy F.D. Association of Environmental Contamination in the Home With the Risk for Recurrent Community-Associated, Methicillin-Resistant Staphylococcus aureus Infection. JAMA Intern Med. 2016 Jun 1;176(6):807-15. doi: 10.1001/jamainternmed.2016.1500.

Knox, J., Uhlemann, A.C. and Lowy, F.D. Transmission of Staphylococcus aureus within households and community. Trends Microbiol, Invited perspective, 20:1-8, 2015. doi: 10.1016/j.tim.2015.03.007. Epub 2015 Apr 9. Review.

Miko BA, Befus M, Herzig CT, Mukherjee DV, Apa ZL, Bai RY, Tanner JP, Gage D, Genovese M, Koenigsmann CJ, Larson EL, Lowy F.D. Epidemiological and biological determinants of Staphylococcus aureus clinical infection in New York State maximum security prisons. Clin Infect Dis. 2015 Jul 15;61(2):203-10. doi: 10.1093/cid/civ242. Epub 2015 Mar 25.

Knox J, Van Rijen M, Uhlemann AC, Miller M, Hafer C, Vavagiakis P, Shi Q, Johnson PD, Coombs G, Kluytmans-Van Den Bergh M, Kluytmans J, Bennett CM, Lowy F.D. Community-associated methicillin-resistant Staphylococcus aureus transmission in households of infected cases: a pooled analysis of primary data from three studies across international settings. Epidemiol Infect. 2015 Jan;143(2):354-65. doi:10.1017/S0950268814000983. Epub 2014 Apr 24.

Tanner J, Lin Y, Kornblum J, Herzig CT, Bystritsky R, Uhlemann AC, Lowy F.D. Molecular characterization of methicillin-resistant Staphylococcus aureus clinical isolates obtained from the Rikers Island Jail System from 2009 to 2013. J Clin Microbiol. 2014 Aug;52(8):3091-4. doi: 10.1128/JCM.01129-14. Epub 2014 Jun 4.

Uhlemann, A-C, Dordel, J., Knox, J., Raven, K., Parkhill, J., Holden, M.T.G., Peacock, S.J. and Lowy, F.D. Molecular tracing of the emergence, diversification and transmission of S. aureus sequence type 8/USA300 in a New York community. Proc Nat Acad Sci USA 111:4988-93, 2014.

Gordon, R.J., Weinberg, A.D., Pagani F.D., Slaughter, M.S., Pappas, P.S., Naka, Y., Goldstein, D.J., Dembitsky, W.P., Giacalone, J.C., Ferrante, J., Ascheim, D.D., Moskowitz, A.J., Rose, E.A., Gelijns, A.C., Lowy, F.D. A prospective, multicenter study of ventricular assist device infections. Circulation 127(6):691-702, 2013

Uhlemann, A-C, Kennedy, A.D., Martens, C., Porcella, F.C. DeLeo, F.R. and Lowy, F.D. Towards an understanding of evolution of Staphylococcus aureus strain USA300 during colonization in community households. Genome Biol Evol. 12:1275-85, 2012

Uhlemann, A.C., Porcella, S.F., Trivedi, S., Sullivan, S.B., Hafer, C., Kennedy, A.D., Barbian, K.D., McCarthy, A.J., Street, C., Hirschberg, D.L., Lipkin, W.I., Lindsay, J.A., DeLeo, F.R., and Lowy, F.D. Identification of a highly transmissible animal-independent Staphylococcus aureus ST398 with distinct genomic and cell adhesion properties. mBio 3, 2012.