Elizabeth Hillman, PhD

Academic Appointments

  • Associate Professor of Biomedical Engineering and Radiology (Physics)
Elizabeth Hillman, PhD

Understanding the cellular and systems-level interrelations between neuronal activity and the hemodynamic response in-vivo in cerebral cortex. Our lab both develops and applies novel optical imaging methodologies to study the brain in-vivo. We are using conventional optical imaging of hemodynamics and voltage and calcium sensitive dyes, a depth-resolved optical imaging technique called Laminar Optical Tomography which can visualize the same changes in 3D to depths of >2mm, and video-rate multi-spectral in-vivo two-photon microscopy. Using these tools we are exploring the hemodynamic responses to somatosensory stimulus, resolving the behavior of the different vascular compartments and examining the controlling mechanisms of the blood flow response. Using calcium sensitive dyes, we can simultaneously observe neuronal and astroglial activity, and are attempting to resolve the interdependence and interconnectivity of all three responses. We hope to apply our findings to allow better interpretation of functional MRI signals, as well as to allow exploration of the effects of disease states and pharmacology on this neurovascular coupling.

Departments and Divisions

  • Department of Biomedical Engineering (Columbia University)

Lab Locations

  • Jerome L. Greene Science Center

    3227 Broadway
    Quad 5B
    New York, NY 10027
    Phone:
    (212) 854-2788
    Email:
    eh2245@columbia.edu

Research Interests

  • Brain Imaging
  • Cognitive/Systems Neuroscience
  • Systems and Circuits

NIH Grants

  • FLEXIBLE TOOLS FOR PRE-CLINICAL STUDIES TO ANSWER KEY QUESTIONS UNDERLYINGHEAVYION RADIOTHERAPY (Federal Gov)

    Apr 5 2019 - Mar 31 2023

    MECHANISMS OF SECOND HEART FIELD DEVELOPMENT REGULATED BY NKX GENES (Federal Gov)

    Jan 1 2017 - Dec 31 2021

    THE ROLE OF IMPAIRED ENDOTHELIUM-DEPENDENT VASOACTIVITY IN NEURODEGENERATION (Federal Gov)

    Jul 1 2015 - Jun 30 2019

    THE ROLE OF IMPAIRED ENDOTHELIUM-DEPENDENT VASOACTIVITY IN NEURODEGENERATION (Federal Gov)

    Jul 1 2015 - Jun 30 2019

    COLUMBIA UNIVERSITY MEDICAL CENTER SKIN DISEASE RESEARCH CENTER (CUMCSDRC) (Federal Gov)

    Jul 20 1997 - Jun 30 2017

    IN-VIVO IMAGING OF THE EVOLUTION OF HEMODYNAMIC CONTROL IN THE DEVELOPING BRAIN (Federal Gov)

    Jul 1 2013 - Jun 30 2015

    TRACKING STEM CELLS IN ENGINEERED TISSUE AND ORGANS IN VIVO AND IN REAL TIME (Federal Gov)

    Sep 15 2009 - Aug 31 2014

    COMPARISON OF OPTICAL IMAGING AND DIFFUSION/PERFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING DURING ACUTE STROKE TO IMPROVE CLINICAL IMAGE INTERPRETATION AND DECISION MAKING (Private)

    Jul 1 2013 - Jun 30 2014

    ANTICIPATORY HEMODYNAMIC SIGNALS IN PRIMARY VISUAL CORTEX (Federal Gov)

    May 1 2009 - Apr 30 2014

    THE ROLE OF INFLAMMATION AND STROMA IN DIGESTIVE CANCER (Federal Gov)

    Sep 30 2006 - Aug 31 2012

Publications

  • Bouchard MB, Voleti V, Mendes C, Lacefield C, Grueber W, Mann R, Bruno R, Hillman EMC, "Swept, confocally aligned planar excitation (SCAPE) microscopy for ultra-fast, volumetric microscopy of behaving organisms", Nature Photonics, 9, 113-119 (2015).
  • Hillman EMC, "Out for Blood", Scientific American MIND, July / Aug (2014).
  • Hillman EMC, "Coupling Mechanism and Significance of the BOLD Signal: A Status Report", Annual Reviews, Neuroscience, 37, 161-181 (2014).
  • Chen BR2, Kozberg MG2, Bouchard MB2, Shaik MA2, Hillman EMC, "A critical role for the vascular endothelium in functional neurovascular coupling in the brain", JAHA, 3: e000787, (2014).
  • Cayce JM, Bouchard MB, Chernov MM, Chen BR, Grosberg LE, Jansen ED, Hillman EMC, Mahadevan-Jansen A. "Calcium imaging of infrared-stimulated activity in rodent brain", Cell Calcium, 55 (4), 183-190(2014).
  • Rayshubskiy A, Wojtasiewicz TJ, Mikell CB, Bouchard MB, Timerman D, Youngerman BE, McGovern RA, Otten ML, Canoll, PD, McKhann II GM, Hillman,EMC. "Direct, intraoperative observation of ~0.1 Hz hemodynamic oscillations in awake human cortex: Implications for fMRI." NeuroImage, 87, 323-331, (2014).
  • Kozberg M, Chen BR, De Leo SE, Bouchard MB, Hillman EMC, "Resolving the transition from negative to positive BOLD in the developing brain", PNAS, 110(11):4380-5 (2013).
  • Grosberg LE, Chen BR, Hillman EMC, "Simultaneous multi-plane in-vivo non-linear microscopy using spectral encoding", Optics Letters, 37(14), 2967-2969 (2012).
  • McCaslin AFH, Chen BR, Radosevich AJ, Cauli B, Hillman EMC, "In-vivo 3D morphology of astrocyte-vasculature interactions in the somatosensory cortex: implications for neurovascular coupling", J Cereb Blood Flow Metab, 31, 795-806 (2011).
  • Chen BR, Bouchard MB, McCaslin AFH, Burgess SA, Hillman EMC, "High-speed vascular dynamics of the hemodynamic response", Neuroimage, 54 (2), 1021-1030 (2011).
  • Hillman E. M. C, "Optical Brain Imaging In-vivo: Techniques and Applications from Animal to Man" [Invited Review] J Biomed Opt, 12(5), 051402 (2007).
  • Hillman E. M. C and Moore A. "All-optical anatomical co-registration for molecular imaging of small animals using dynamic contrast", Nature Photonics, 1 (9), 526 - 530, (2007).

For a complete list of publications, please visit PubMed.gov