Alan R Tall, MD

Academic Appointments

  • Tilden-Weger-Bieler Professor of Medicine
  • Professor of Physiology & Cellular Biophysics
Alan R Tall, MD

The laboratory is carrying out research on the molecular mechanisms responsible for human diseases. The approach is to use molecular, genomic and cellular approaches to investigate basic aspects of the pathogenesis of atherosclerosis. A major focus is on molecular mechanisms of cellular cholesterol efflux, mediated by the interaction of extracellular apoA-I with the lipid transporter ABCA1. We are carrying out studies on the transcriptional regulation of ABCA1 gene expression, and regulation of the degradation of ABCA1 protein. This has led to the elucidation of a class of transcription factors (LXRs) that co-ordinately regulate cellular cholesterol efflux and reverse cholesterol transport.

Departments and Divisions

  • Department of Medicine
    Division of Molecular Medicine
    Division of Molecular Medicine

Board Certifications

  • Internal Medicine

Areas of Expertise

  • Pulmonology

Education and Training

  • University of Sydney, Faculty of Medicine (Australia)
  • Internship: Royal Prince Alfred Hospital
  • Residency: Boston Medical Center
  • Fellowship: Boston Medical Center

Centers / Institutes / Programs

  • Institute of Human Nutrition

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Contact Phone Number: 2123059418

Honors and Awards

1996 - 1998, Tenure Review Advisory Committee, Columbia; University
1993 - 1995, Committee on Appointments and Promotions, Columbia University, Chairman, 1995.

NIH Grants

  • CLONAL HEMATOPOIESIS AND ATHEROSCLEROSIS (Private)

    Sep 1 2018 - Dec 31 2023

    MECHANISMS OF ATHEROGENESIS IN INSULIN RESISTANCE (Federal Gov)

    Aug 1 2018 - Jun 30 2023

    ABCA1/G1 AND LXRS IN ATHEROGENESIS (Federal Gov)

    Jun 1 2011 - May 31 2023

    TTC39B IN METABOLISM (Federal Gov)

    Dec 18 2018 - Nov 30 2022

    ROLE OF NETS IN ATHERO-THROMBOSIS IN LNK/SH2B3 DEFICIENT MICE (Private)

    Jan 1 2020 - Dec 31 2021

    MECHANISMS LINKING LNK GENETIC VARIATION TO ATHEROTHROMBOSIS (Federal Gov)

    Jul 1 2017 - May 31 2021

    HDL-MEDIATED CHOLESTEROL EFFLUX AND PLAQUE INFLAMMATION IN MESA (Federal Gov)

    Jul 1 2016 - Apr 30 2021

    CARDIOVASCULAR CONSEQUENCES OF INCREASED INFLAMMASOME ACTIVATION IN JAK2VF-MEDIATED CLONAL HEMATOPOIESIS (Federal Gov)

    Mar 1 2020 - Feb 28 2021

    TRANSCRIPTIONAL REGULATION OF MACROPHAGE FUNCTION BY LXR IN ATHEROSCLEROSIS (Federal Gov)

    Jul 1 2018 - Jun 30 2020

    HDL-MEDIATED CHOLESTEROL EFFLUX AND PLAQUE INFLAMMATION IN MESA (Federal Gov)

    Jul 1 2016 - Apr 30 2020

    HDL-MEDIATED CHOLESTEROL EFFLUX AND PLAQUE INFLAMMATION IN MESA (Federal Gov)

    Jul 1 2016 - Apr 30 2020

    CLONAL HEMATOPOIESIS AND ATHEROSCLEROSIS (Private)

    Sep 1 2018 - Dec 31 2019

    ABCA1/G1 AND LXRS IN ATHEROGENESIS (Federal Gov)

    Jun 1 2015 - May 31 2019

    ABCA1/G1 AND LXRS IN ATHEROGENESIS (Federal Gov)

    Jun 1 2015 - May 31 2019

    ANALYZEBIOLOGICAL SAMPLES OF GENES, RNA, PROTEINS AND METABOLITES FROM PFIZER'S BIOBANK AND TISSUE BANK - PHASE 3 RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED PARALLEL-GROUP STUDY OF THE EFFICACY AND SAFETY OF 2 ORAL DOSES OF CP-690... (P&S Industry Clinical Trial)

    May 23 2014 - May 23 2019

    TTC39B IN METABOLISM (Federal Gov)

    Nov 4 2014 - Oct 31 2018

    MECHANISMS OF ATHEROGENESIS IN INSULIN RESISTANCE (Federal Gov)

    Feb 1 2013 - Jan 31 2018

    MECHANISMS OF ATHEROGENESIS IN INSULIN RESISTANCE (Federal Gov)

    Feb 1 2013 - Jan 31 2018

    MECHANISMS OF ATHEROGENESIS IN INSULIN RESISTANCE (Federal Gov)

    Feb 1 2013 - Jan 31 2018

    HYPERINSULINEMIA,MTOR ACTIVITY AND PLASMA LIPOPROTEINS (Federal Gov)

    Apr 16 2012 - Mar 31 2016

    HIGH DENSITY LIPOPROTEIN DYSFUNTION IN DEVELOPMENT OF CARDIOVASCULAR DISEASE AND A THERAPEUTIC TARGET (Private)

    Oct 1 2010 - Sep 30 2015

    ABCG1 AND ENDOTHELIAL FUNCTION (Federal Gov)

    Jan 3 2011 - Dec 31 2014

    ABCG1 AND ENDOTHELIAL FUNCTION (Federal Gov)

    Jan 3 2011 - Dec 31 2014

    ABCG1 AND ENDOTHELIAL FUNCTION (Federal Gov)

    Jan 3 2011 - Dec 31 2014

    THEROLE OF THE IL-3 RECEPTOR COMMON B-SUBUNIT IN REGULATING HSPC PROLIFERATION, MONOCYTOSIS AND ATHEROSCLEROSIS (Private)

    Jul 1 2012 - Jun 30 2014

    STUDY OF THE ROLE OF EXENATIDE IN ATHEROSCLEROTIC PLAQUE STABILIZATION IN A MURINE MODEL (Private)

    Feb 10 2010 - Feb 9 2014

    USE OF PEGYLATED HUMAN APOA-1 FOR THE TREATMENT OF ATHEROSCL EROSIS-PHASE 1 (Private)

    Dec 22 2009 - Dec 21 2013

    MACROPHAGEFOAM CELLS, CATHEPSINS AND CHOLESTEROL EFFLUX (Federal Gov)

    Jul 1 1978 - Jul 31 2012

    THE ROLE OF MYELOID CELL PROLIFERATION IN ATHEROGENESIS IN M ICE WITH DEFICIENCY ON ABC TRANSPORTERS IN BONE MARROW CELLS (Private)

    Jul 1 2009 - Jun 30 2012

    THE ROLE OF ABCA1 IN ATHEROSCLEROSIS REGRESSION (Private)

    Jul 1 2010 - Jun 30 2012

    ROLE OF ENDOTHELIAL CHOLESTEROL TRANSPORTERS IN ATHEROGENESI S (Private)

    Jul 1 2009 - Jun 30 2011

    NEW GENES AND PATHWAYS INVOLVED IN ATHEROSCLEROSIS PROJECT (Federal Gov)

    Jul 1 1997 - Mar 31 2011

    HDL AND ENDOTHELIAL FUNCTION: STUDIES WITH HDL FROM ANACETRA PIBTREATED SUBJECTS (Private)

    Dec 8 2008 - Dec 7 2009

    MEASURE ANTI-INFLAMATORY PROPERITIES OF HDL IN SUBJECT TREAT ED WITH MERCK CETP INHIBITOR (Private)

    Jun 13 2007 - Jun 12 2008

    STUDY TO EXAMINE THE EFFECTS OF PHARMACEUTICAL AGENTS ON HDL FUNCTION (Private)

    Nov 1 2006 - Oct 31 2007

    GENETICS OF ATHEROSCLEROSIS--FROM MICE TO HUMANS (Private)

    Jul 1 2003 - Jun 30 2007

Publications

  • Wang N, Chen W, Linsel-Nitschke P, Martinez L, Agerholm-Larsen B, Silver DL, Tall AR. (2003 ) A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I. J Clin Invest. 111(1):99-107
  • Tall AR. (2002 ) Exercise to reduce cardiovascular risk - how much is enough? N Engl J Med. 347(19):1522-4
  • Tall AR, Costet P, Wang N. (2002 ) Regulation and mechanisms of macrophage cholesterol efflux. J Clin Invest. 110(7):899-904
  • Jiang, XC, Qin, S, Qiao, C, Kawano, K, Lin, M, Xiao, X, Tall, AR. (2001 ) Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency. Nat. Med. 7(7):847-52
  • Luo Y, Liang CP, Tall AR. (2001 ) The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by liver X receptor. J Biol Chem. Jul 6;:. 276(27):24767-73
  • Welch CL, Bretschger S, Latib N, Bezouevski M, Guo Y, Pleskac N, Liang C-P, Barlow C, Dansky H, Breslow JL, Tall AR. (2001 ) Localization of atherosclerosis susceptibility loci to chromosomes 4 and 6 using the Ldlr knockout mouse model. PNAS 98(14):7946-51

For a complete list of publications, please visit PubMed.gov