Andreas H. Kottmann, PhD

Academic Appointments

  • Adjunct Assistant Professor of Pathology and Cell Biology
Andreas H. Kottmann, PhD

Email: ak139@cumc.columbia.edu

We study the regulation of competitive processes that lead to the structural and functional stability of the central nervous system and at the same time allow structural and functional plasticity necessary for learning and memory. We focus our research on the mesencephalic dopaminergic system and the spinal motor neuron system. Our work is of relevance to two prominent, progressive neurodegenerative disorders, Parkinson’s Disease and Amyotrophic Lateral Sclerosis.

Departments and Divisions

  • Department of Pathology & Cell Biology

Research Interests

  • The mesencephalic dopaminergic system and the spinal motor neuron system

NIH Grants

  • WINGS OVER WALL STREET - ALS RESEARCH CENTER AT CUMC (Private)

    Jul 1 2006 - Jan 31 2013

    DOES GRADED EXPRESSION OF SHH BY DOPAMINERGIC NEURONS OF THE MESENCEPHALON INFLUENCE THE MAINTENANCE AND DIFFERENTIATION (NY State Gov)

    Jan 1 2009 - Jun 30 2011

    REGULATION OF GDNF EXPRESSION BY CYCLOPMAINE IN THE MPTP MOD EL OF PARKINSON"S DISEASE (Private)

    Jun 22 2009 - Jan 31 2011

    ONTHE FUNCTION OF SONIC HEDGEHOG EXPRESSION BY MESENCEPHALIC, DOPAMINERGIC NEURONS (Private)

    Sep 1 2006 - Aug 31 2008

Publications

Gonzalez-Reyes LE, Verbitsky M, Blesa J, Jackson-Lewis V, Paredes D, Tillack K, Phani S, Kramer ER, Przedborski S, Kottmann AH. Sonic hedgehog maintains cellular and neurochemical homeostasis in the adult nigrostriatal circuit. Neuron. 2012 Jul 26;75(2):306-19.