Antonio Iavarone, MD

Academic Appointments

  • Professor of Neurology
  • Professor of Pathology and Cell Biology (in the Institute for Cancer Genetics)
Antonio Iavarone, MD

Email: ai2102@cumc.columbia.edu

The research program pursued by Antonio Iavarone seeks to unravel the biologic and genetic alterations driving subgroups of malignant brain tumors and exploit this information for rational therapeutic stratification. The Iavarone group identified master regulators of cancer initiation and progression in distinct sub-groups of brain tumors. They discovered the first example of oncogenic and tumor addicting gene fusions in glioblastoma (FGFR3-TACC3) and reported that FGFR3-TACC3 fusions trigger tumorigenesis through activation of oxidative phosphorylation. These fusions are among the most frequent chromosomal translocations across all types of human cancer and the FDA approved the targeting of these chromosomal translocations with FGFR inhibitors. Antonio Iavarone chaired the Pan-Glioma ATLAS-TCGA Working Group and the Neurofibromatosis 1 synodos that united international researchers to formulate guidelines for accurate diagnosis and prognosis of glioma patients. By using all the computational and experimental tools at disposal, they combine innovations in both areas to continue making transformative mechanistic discoveries and provide personalized therapeutics to increasing number of patients with deadly tumor types.

Departments and Divisions

  • Department of Pathology & Cell Biology
  • Department of Neurology

Centers / Institutes / Programs

  • Herbert Irving Comprehensive Cancer Center
  • Institute for Cancer Genetics

NIH Grants

  • THEHUWE1 UBIQUITIN LIGASE REGULATES MITOSIS, GENOMIC STABILITY AND ONCOGENESIS (Federal Gov)

    Jul 1 2019 - Jun 30 2024

    MECHANISMS OF ID2 REGULATION IN GLIOMA (Federal Gov)

    Apr 1 2019 - Mar 31 2024

    DISSECTING THE TUMOR MICROENVIRONMENT OF GLIOMA FROM NEUROFIBROMATOSIS 1 PATIENTS BY SINGLE CELL ANALYSIS (Federal Gov)

    Jul 1 2020 - Jun 30 2023

    DISSECTING THE TUMOR MICROENVIRONMENT OF GLIOMA BY SINGLE CELL ANALYSIS (Private)

    Apr 1 2020 - Mar 31 2022

    LICENSE PATHWAY AGREEMENT (Private)

    Dec 1 2017 - Nov 30 2021

    TOPOLOGY OF CANCER EVOLUTION AND HETEROGENEITY (Federal Gov)

    May 19 2015 - Apr 30 2021

    THE ROLE OF THE LZTR1 UBIQUITIN LIGASE IN STEM CELLS AND CANCER (Federal Gov)

    May 15 2015 - Apr 30 2021

    DETERMINING THE MOLECULAR BASIS OF SCHWANNOMATOSIS THROUGH IDENTIFICATION OF LZTR1 SUBSTRATES (Private)

    Jul 1 2019 - Jun 30 2020

    TOPOLOGY OF CANCER EVOLUTION AND HETEROGENEITY (Federal Gov)

    May 19 2015 - Apr 30 2020

    THE ROLE OF THE LZTR1 UBIQUITIN LIGASE IN STEM CELLS AND CANCER (Federal Gov)

    May 15 2015 - Apr 30 2020

    TOPOLOGY OF CANCER EVOLUTION AND HETEROGENEITY (Federal Gov)

    May 19 2015 - Apr 30 2020

    THE ROLE OF THE LZTR1 UBIQUITIN LIGASE IN STEM CELLS AND CANCER (Federal Gov)

    May 15 2015 - Apr 30 2020

    IDENTIFICATION OF MECHANISMS OF RESISTANCE AND COMPOUNDS WITH DUAL INHIBITORY ACTIVITY AGAINST FGFRTACC FUSIONS (Private)

    Jan 1 2018 - Dec 31 2019

    CANCER CENTER SUPPORT GRANT (Federal Gov)

    Jul 1 2014 - Jun 30 2019

    THE MECHANISMS DRIVING BRAIN ONCOGENESIS BY FGFR-TACC GENE FUSIONS (Federal Gov)

    Jul 2 2014 - May 31 2019

    THE MECHANISMS DRIVING BRAIN ONCOGENESIS BY FGFR-TACC GENE FUSIONS (Federal Gov)

    Jul 2 2014 - May 31 2019

    (PQB5) RECONSTRUCTION OF EVOLUTIONARY NETWORKS USING CROSS-SECTIONAL GENOMIC DATA (Federal Gov)

    Apr 1 2014 - Apr 30 2019

    ESTABLISHING THE GENOMIC AND EPIGENOMIC LANDSCAPE OF SCHWANNOMATOSIS FOR BETTER UNDERSTANDING OF THE MECHANISMS OF DISEASE (Private)

    Mar 1 2017 - Feb 28 2019

    IDENTIFICATION AND MODELING OF DRIVER GENETIC MODULES IN GLIOBLASTOMA (Federal Gov)

    Dec 10 2013 - Nov 30 2018

    IDENTIFICATION AND MODELING OF DRIVER GENETIC MODULES IN GLIOBLASTOMA (Federal Gov)

    Dec 10 2013 - Nov 30 2018

    IDENTIFICATION,FUNCTIONAL CHARACTERIZATION AND THERAPEUTIC EXPLOITATION OF THE INTEGRATED LANDSCAPE OF GENETIC AND EPIGENETIC ALTERATIONS IN GLIOMA FROM PATIENTS WITH NF1 (Private)

    Oct 1 2015 - Sep 30 2018

    (PQB5) RECONSTRUCTION OF EVOLUTIONARY NETWORKS USING CROSS-SECTIONAL GENOMIC DATA (Federal Gov)

    Apr 1 2014 - Apr 30 2018

    (PQB5) RECONSTRUCTION OF EVOLUTIONARY NETWORKS USING CROSS-SECTIONAL GENOMIC DATA (Federal Gov)

    Apr 1 2014 - Apr 30 2018

    (PQB5) RECONSTRUCTION OF EVOLUTIONARY NETWORKS USING CROSS-SECTIONAL GENOMIC DATA (Federal Gov)

    Apr 1 2014 - Apr 30 2018

    FUNCTIONAL ANALYSIS AND MODELING OF FGFR-TACC FUSION IN BRAIN CANCER (Private)

    Mar 1 2017 - Feb 28 2018

    IDENTIFICATION OF MECHANISMS OF RESISTANCE AND COMPOUNDS WITH DUAL INHIBITORY ACTIVITY AGAINST FGFR-TACC FUSIONS (Private)

    Jan 1 2016 - Dec 31 2017

    SYSTEMS BIOLOGY OF TUMOR PROGRESSION AND DRUG RESISTANCE (Federal Gov)

    Jun 1 2012 - Apr 30 2017

    SYSTEMS BIOLOGY OF TUMOR PROGRESSION AND DRUG RESISTANCE (Federal Gov)

    Jun 1 2012 - Apr 30 2017

    EFFICACY STUDY OF TAS-120 IN PRIMARY GBM CELLS HARBORING FGFR-TACC FUSIONS (Private)

    Nov 5 2015 - Nov 4 2016

    IDENTIFICATION OF DRUG SENSITIVITY OF GRADE IV ASTROCYTC TUMOURS BASED ON GENETIC LESIONS (Private)

    Jul 1 2014 - Jun 30 2016

    THE ROLE OF CTNND2 INACTIVATION IN MESENCHYMAL GLIOBLASTOMA (Private)

    Jul 1 2014 - Jun 30 2016

    IDENTIFICATION OF CTNND2-ASSOCIATED TRANSFORMATION PATHWAYS IN MESENCHYMAL GLIOBLASTOMA USING INSERTIONAL MUTAGENESIS (Private)

    Jan 1 2014 - Dec 31 2015

    COMPUTATIONAL ANALYSIS OF HIGH-GRADE GLIOMAS (Federal Gov)

    Sep 1 2009 - Aug 31 2015

    THE ROLE OF ID PROTEINS IN TUMOR DEVELOPMENT AND ANGIOGENESIS IN THE BRAIN (Federal Gov)

    Jun 1 2003 - Jul 31 2015

    FGFR COMPOUND AZD4547 IN VITRO AND IN VIVO EFFECTS ON GLIOBLASTOMA MULTIFORME (Private)

    Oct 17 2013 - Oct 16 2014

    THE UREB-1 UBIQUITIN LIGASE IN NEURAL STEM CELLS AND CANCER (Federal Gov)

    Sep 1 2008 - Jul 31 2014

    DEVELOPMENT OF PERSONALIZED ANTI-GLIOMA THERAPEUTICS AND ELUCIDATION OF MOLECULAR MECHANISMS OF ACTION (Private)

    Jan 1 2012 - Dec 31 2013

    MECHANISMS AND REGULATION OF POST-TRANSLATIONAL MODIFICATIONS OF ID PROTEINS (Federal Gov)

    Dec 1 2007 - Nov 30 2013

    IDENTIFICATION AND VALIDATION OF NEW GENETIC ALTERATIONS IN PEDIATRIC BRAIN TUMORS (Private)

    Jun 1 2011 - Jul 30 2013

    THE ROLE OF ID PROTEINS IN DEVELOPMENT AND CANCER OF THE NER VOUS SYSTEM (Private)

    Jan 1 2007 - Dec 31 2012

    SYSTEMS BIOLOGY OF TUMOR PROGRESSION AND DRUG-RESISTANCE (Federal Gov)

    Sep 30 2009 - Aug 31 2012

    INHIBITOR OF DIFFERENTIATION- 2 IN CELL CYCLE REGULATION AND CANCER (Federal Gov)

    Sep 30 2006 - Jul 31 2012

    THE HUWE1-N-MYC TRANSCRIPTIONAL NETWORK AS A NEW THERAPEUTIC TARGET IN MALIGNANT GLIOMA (Private)

    Jan 1 2010 - Dec 31 2011

Publications

  1. Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation
    Lee SB, Ko A, Oh YT, Shi P, D'Angelo F, Frangaj B, Koller A, Chen EI, Cardozo T, Iavarone A, Lasorella A
    Mol Cell. 2020.
    PMID: 32640193, DOI: 10.1016/j.molcel.2020.06.021
  2. ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages
    Yin J, Kim SS, Choi E, Oh YT, Lin W, Kim TH, Sa JK, Hong JH, Park SH, Kwon HJ, Jin X, You Y, Kim JH, Kim H, Son J, Lee J, Nam DH, Choi KS, Shi B, Gwak HS, Yoo H, Iavarone A, Kim JH, Park JB
    Nat Commun. 2020.
    PMID: 32532977, DOI: 10.1038/s41467-020-16789-2
  3. Clinical, molecular and radiomic profile of gliomas with FGFR3-TACC3 fusions
    Di Stefano AL, Picca A, Saragoussi E, Bielle F, Ducray F, Villa C, Eoli M, Paterra R, Bellu L, Mathon B, Capelle L, Bourg V, Gloaguen A, Philippe C, Frouin V, Schmitt Y, Lerond J, Leclerc J, Lasorella A, Iavarone A, Mokhtari K, Savatovsky J, Alentorn A, Sanson M
    Neuro-oncology. 2020.
    PMID: 32413119, DOI: 10.1093/neuonc/noaa121
  4. The molecular landscape of glioma in patients with Neurofibromatosis 1
    D'Angelo F, Ceccarelli M, Tala , Garofano L, Zhang J, Frattini V, Caruso FP, Lewis G, Alfaro KD, Bauchet L, Berzero G, Cachia D, Cangiano M, Capelle L, de Groot J, DiMeco F, Ducray F, Farah W, Finocchiaro G, Goutagny S, Kamiya-Matsuoka C, Lavarino C, Loiseau H, Lorgis V, Marras CE, McCutcheon I, Nam DH, Ronchi S, Saletti V, Seizeur R, Slopis J, Suñol M, Vandenbos F, Varlet P, Vidaud D, Watts C, Tabar V, Reuss DE, Kim SK, Meyronet D, Mokhtari K, Salvador H, Bhat KP, Eoli M, Sanson M, Lasorella A, Iavarone A
    Nat Med. 2019.
    PMID: 30531922, DOI: 10.1038/s41591-018-0263-8
  5. The combination of neoantigen quality and T lymphocyte infiltrates identifies glioblastomas with the longest survival
    Zhang J, Caruso FP, Sa JK, Justesen S, Nam DH, Sims P, Ceccarelli M, Lasorella A, Iavarone A
    Commun Biol. 2019.
    PMID: 31044160, DOI: 10.1038/s42003-019-0369-7
  6. Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy
    Lee JK, Liu Z, Sa JK, Shin S, Wang J, Bordyuh M, Cho HJ, Elliott O, Chu T, Choi SW, Rosenbloom DIS, Lee IH, Shin YJ, Kang HJ, Kim D, Kim SY, Sim MH, Kim J, Lee T, Seo YJ, Shin H, Lee M, Kim SH, Kwon YJ, Oh JW, Song M, Kim M, Kong DS, Choi JW, Seol HJ, Lee JI, Kim ST, Park JO, Kim KM, Song SY, Lee JW, Kim HC, Lee JE, Choi MG, Seo SW, Shim YM, Zo JI, Jeong BC, Yoon Y, Ryu GH, Kim NKD, Bae JS, Park WY, Lee J, Verhaak RGW, Iavarone A, Lee J, Rabadan R, Nam DH
    Nat Genet. 2018.
    PMID: 30262818, DOI: 10.1038/s41588-018-0209-6
  7. Diffuse gliomas with FGFR3-TACC3 fusion have characteristic histopathological and molecular features
    Bielle F, Di Stefano AL, Meyronet D, Picca A, Villa C, Bernier M, Schmitt Y, Giry M, Rousseau A, Figarella-Branger D, Maurage CA, Uro-Coste E, Lasorella A, Iavarone A, Sanson M, Mokhtari K
    Brain Pathol. 2018.
    PMID: 28976058, DOI: 10.1111/bpa.12563
  8. A metabolic function of FGFR3-TACC3 gene fusions in cancer
    Frattini V, Pagnotta SM, Tala , Fan JJ, Russo MV, Lee SB, Garofano L, Zhang J, Shi P, Lewis G, Sanson H, Frederick V, Castano AM, Cerulo L, Rolland DCM, Mall R, Mokhtari K, Elenitoba-Johnson KSJ, Sanson M, Huang X, Ceccarelli M, Lasorella A, Iavarone A
    Nature. 2018.
    PMID: 29323298, DOI: 10.1038/nature25171
  9. Clonal evolution of glioblastoma under therapy
    Wang J, Cazzato E, Ladewig E, Frattini V, Rosenbloom DI, Zairis S, Abate F, Liu Z, Elliott O, Shin YJ, Lee JK, Lee IH, Park WY, Eoli M, Blumberg AJ, Lasorella A, Nam DH, Finocchiaro G, Iavarone A, Rabadan R
    Nat Genet. 2016.
    PMID: 27270107, DOI: 10.1038/ng.3590
  10. Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma
    Ceccarelli M, Barthel FP, Malta TM, Sabedot TS, Salama SR, Murray BA, Morozova O, Newton Y, Radenbaugh A, Pagnotta SM, Anjum S, Wang J, Manyam G, Zoppoli P, Ling S, Rao AA, Grifford M, Cherniack AD, Zhang H, Poisson L, Carlotti CG, Tirapelli DP, Rao A, Mikkelsen T, Lau CC, Yung WK, Rabadan R, Huse J, Brat DJ, Lehman NL, Barnholtz-Sloan JS, Zheng S, Hess K, Rao G, Meyerson M, Beroukhim R, Cooper L, Akbani R, Wrensch M, Haussler D, Aldape KD, Laird PW, Gutmann DH, , Noushmehr H, Iavarone A, Verhaak RG
    Cell. 2016.
    PMID: 26824661, DOI: 10.1016/j.cell.2015.12.028
  11. Detection, Characterization, and Inhibition of FGFR-TACC Fusions in IDH Wild-type Glioma
    Di Stefano AL, Fucci A, Frattini V, Labussiere M, Mokhtari K, Zoppoli P, Marie Y, Bruno A, Boisselier B, Giry M, Savatovsky J, Touat M, Belaid H, Kamoun A, Idbaih A, Houillier C, Luo FR, Soria JC, Tabernero J, Eoli M, Paterra R, Yip S, Petrecca K, Chan JA, Finocchiaro G, Lasorella A, Sanson M, Iavarone A
    Clin Cancer Res. 2015.
    PMID: 25609060, DOI: 10.1158/1078-0432.CCR-14-2199
  12. The integrated landscape of driver genomic alterations in glioblastoma
    Frattini V, Trifonov V, Chan JM, Castano A, Lia M, Abate F, Keir ST, Ji AX, Zoppoli P, Niola F, Danussi C, Dolgalev I, Porrati P, Pellegatta S, Heguy A, Gupta G, Pisapia DJ, Canoll P, Bruce JN, McLendon RE, Yan H, Aldape K, Finocchiaro G, Mikkelsen T, Privé GG, Bigner DD, Lasorella A, Rabadan R, Iavarone A
    Nat Genet. 2013.
    PMID: 23917401, DOI: 10.1038/ng.2734
  13. Transforming fusions of FGFR and TACC genes in human glioblastoma
    Singh D, Chan JM, Zoppoli P, Niola F, Sullivan R, Castano A, Liu EM, Reichel J, Porrati P, Pellegatta S, Qiu K, Gao Z, Ceccarelli M, Riccardi R, Brat DJ, Guha A, Aldape K, Golfinos JG, Zagzag D, Mikkelsen T, Finocchiaro G, Lasorella A, Rabadan R, Iavarone A
    Science. 2012.
    PMID: 22837387, DOI: 10.1126/science.1220834
  14. The transcriptional network for mesenchymal transformation of brain tumours
    Carro MS, Lim WK, Alvarez MJ, Bollo RJ, Zhao X, Snyder EY, Sulman EP, Anne SL, Doetsch F, Colman H, Lasorella A, Aldape K, Califano A, Iavarone A
    Nature. 2010.
    PMID: 20032975, DOI: 10.1038/nature08712

For a complete list of publications, please visit PubMed.gov