Research and Staff Opportunities

Postdoctoral Fellowship in Translational Immunology

The lab of Ran Reshef is inviting greatly motivated, creative and experienced individuals with a strong interest in innovative immunology research that is at the interface of transplantation and cancer immunology and will have significant translational potential. Our lab focuses on immune responses after hematopoietic stem-cell transplantation and CAR T cell therapies using pre-clinical models, human biospecimens and early phase clinical trials.

Projects in the lab evolve from our published work (Reshef NEJM 2012, Reshef JCO 2015, Moy Blood 2017, Harle ASH 2020) and are funded by several NIH and Department of Defense grants. The lab is part of the Columbia Center for Translational Immunology that is equipped with state-of-the-art resources including CyTOF, full spectrum flow cytometry (Cytek), 10x genomics platform, humanized mice core and immune monitoring core. We work in close collaboration with computational biologists in the Department of biomedical Engineering and manage a unique biospecimen bank that contains blood and tissue samples from recipients of bone marrow transplants and CAR T cell therapies.

Minimum Qualifications

A strong background in immunology and technical experience are required. Must have a PhD or MD degree.

Apply

Applicants should submit a CV, brief description of accomplishments and goals, and contact information of 3 references to: ran.reshef@columbia.edu

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Columbia University is committed to the hiring of qualified local residents.


 

Flow Cytometry Specialist, Columbia University, New York, NY

The Columbia Center for Translational Immunology (CCTI) at Columbia University Irving Medical Center is a multi-departmental, multidisciplinary research center aimed at optimizing translation of advances in basic immunology from the laboratory to the clinic, understanding immunological diseases and events in humans and optimizing transfer of information and methodologies to achieve synergy between different disciplines of applied immunology. The CCTI Flow Cytometry Core provides training and access to state-of-the-art flow cytometry instruments for biomedical investigators. The Core operates at two sites (CCTI and Cancer Center) and is equipped with 5 analyzers (LSRII, Fortessa, CantoII) and 4 cell sorters (Influx and AriaII). It also operates an Aurora spectral flow cytometer.

The Flow Cytometry Core is recruiting a flow cytometry operator at the level of Staff Associate. Responsibilities include: perform routine cell sorting for user; maintenance, quality control and trouble shooting of analyzers; ensure compliance with safety and regulatory requirements, provide scientific advice on experimental planning and troubleshooting; performs additional related duties as assigned.

Minimum Qualifications

Requires a master’s degree in biology or related subject and at least one year of laboratory experience, or a bachelor's degree in biology or related subject and at least 4 years of related experience or equivalent in education, training and experience. The candidate selected for this position is required to undergo a drug screening test prior to a final offer of employment being made.

Additional Qualifications

The desired candidate must be detail-oriented; possess excellent interpersonal, organizational and communication skills. Must be able to multi-task, maintain confidentiality, think creatively, work well as part of a team, and work well under pressure.

Experience with flow cytometry required. Experience with BD instruments and software (Diva) highly desirable. Knowledge and bench experience in the field of immunology, stem cells and/or hematology desirable.

Apply

Please send cover letter, CV and list of references by email to the Core Director, Dr. Remi Creusot: rjc2150@columbia.edu

Equal Opportunity Employer / Disability / Veteran
Columbia University is committed to the hiring of qualified local residents.


 

Laboratory Technician A

The Columbia Center for Translational Immunology (CCTI) is seeking a highly motivated and talented technician to join our team. The laboratory is looking for a team member who can assist with lab organization and immunological assays. We collaborate closely with renowned scientists and physicians across multiple departments at CUIMC spanning research in cancers, cancer therapy, immunology, autoimmunity, transplantation, inflammation, infectious diseases, and others.

Key responsibilities include: operation, maintenance of research laboratory; preparation of samples and reagents; and assistance in immunological assay development and optimization.

Responsibilities

  • Assist in the development of new assays, methods, and reagents
  • Runs high-volume ELISA
  • Maintain a detailed, up-to-date, and accurate record of samples, reagents, instrument tuning and QC
  • Perform routine data processing and assists with data analysis
  • Maintain and organize supplies inventory
  • Order supplies and prepare service bills
  • Contribute to building a culture that embraces scientific excellence, integrity, efficiency, teamwork, and continuous learning and improvement
  • Perform other related duties necessary to the functioning of the laboratory

Minimum Qualifications

  • Two years of college or a completed A.A. program with an emphasis on chemistry, biology, physics, or physics
  • One year of related experience or equivalent in training and experience

Preferred Qualifications

  • Previous experience in lab research, especially working with immunological assays and ELISA

Other Requirements

  • The candidate selected for this position is required to undergo a drug screening test prior to a final offer of employment being made
  • Successful completion of applicable compliance and systems training requirements
  • Participation in the medical surveillance program
  • Ability to work with laboratory animals
  • Potential bloodborne pathogen exposure

Apply

To apply, email Dr. Emmanuel Zorn: ez2184@cumc.columbia.edu

Equal Opportunity Employer / Disability / Veteran
Columbia University is committed to the hiring of qualified local residents.


 

Laboratory Technician B

The Columbia Center for Translational Immunology CCTI is looking for a technician to work in the Cellular Immunotherapy Laboratory on the T cell responses in the context of viral infections (including COVID-19) and cell-based immunotherapy of cancer.

The technician will work with PIs and post-doctoral fellows but will be expected to take on supervised projects and responsibility for sample processing, tissue cultures and assays. These will be rewarded with ownership of projects as appropriate.

Responsibilities

  • Performing assays and prepare solutions according to detailed instructions
  • Set up equipment for experiments, maintain cell cultures and perform functional studies using flow cytometry and other techniques
  • Carry out fully planned experiments and keep records of results
  • Assist with collection, processing, and cryopreservation of samples for experimental or diagnostic purpose
  • Order and maintain laboratory supplies
  • Perform other related duties as assigned or necessary to the functioning of the laboratory and research

Minimum Qualifications

  • Bachelor's degree in chemistry, biology or physics or related science or equivalent in education, training and experience
  • Ability to perform work in a neat and orderly manner in accordance with safety regulations
  • Ability to organize experiments in standard form and record data in a scientific notebook
  • Ability to learn and adapt to new techniques

Preferred Qualifications

  • Knowledge of chemistry, biology or physics and various related laboratory procedures and techniques
  • Knowledge of experimental materials and standardization
  • Exposure to experimental procedures, laboratory equipment and/or working with animals
  • Familiarity with computerized operations

Other Requirements

  • The candidate selected for this position is required to undergo a drug screening test prior to a final offer of employment being made
  • Successful completion of applicable compliance and systems training requirements
  • Participation in the medical surveillance program
  • Ability to work with laboratory animals
  • Potential bloodborne pathogen exposure.

Apply

To apply, email Dr. Pawel Muranski: pjm2170@cumc.columbia.edu

Equal Opportunity Employer / Disability / Veteran
Columbia University is committed to the hiring of qualified local residents.

_______________________________________________________________________________________________________

POSTDOCTORAL RESEARCH OPPORTUNITY in Translational Immunology


Columbia Center for Translational Immunology and the Blood and Marrow Transplantation and Cell Therapy Program, Columbia University Irving Medical Center, New York, NY

     The lab of Megan Sykes, MD, is inviting highly motivated, creative and experienced individuals with a strong interest in innovative immunology research in transplantation tolerance and autoimmune disease with significant translational potential. Human immune systems from patients and other hematopoietic cell sources will be developed and analyzed in human immune system mouse models.  These projects evolve from more than 25 years of experience in these models and benefit from a strong infrastructure and expertise within the laboratory. The work is supported by the extensive resources of the Columbia Center for Translational Immunology and affiliated centers, including CyTOF, full spectrum flow cytometry (Cytek Aurora), 10x genomics platform, humanized mouse core and human studies core. We work in close collaboration with computational biologists in the Department of Systems Biology. 

Qualifications


A strong background in immunology and technical experience are required. Must have a PhD and/or MD degree.
 

Apply


Applicants should submit a CV, brief description of accomplishments and goals, and contact information of 3 references to CCTIassistant@cumc.columbia.edu
Equal Opportunity Employer / Disability / Veteran
Columbia University is committed to the hiring of qualified local residents.

_____________________________________________________________________________________________

Laboratory Technician A 

 

Position Summary

Primary duties include assisting in the continuous and smooth operation of the laboratory; conducting biological assays to monitor immune responses in patients undergoing transplantation or CAR-T cell therapies; and assisting in mouse bone marrow transplant studies. The technician will learn and implement a variety of techniques including flow cytometry, cell culture, single-cell sequencing and immunohistochemistry.

Responsibilities

  • Assist with experiments in cell culture and animal models under supervision.
  • Maintain a detailed, up-to-date, and accurate record of samples, reagents, instrument
  • tuning and QC.
  • Assist in the development of new assays, methods, and reagents.
  • Perform routine data processing and assist with data analysis.
  • Order reagents, organize inventory, maintain equipment, and prepare service bills.
  • Contribute to building a culture that embraces scientific excellence, integrity, efficiency, teamwork, and continuous learning and improvement.
  • Perform additional related duties as assigned.
  • Minimum Qualifications
  • Two years of college or a completed A.A. program with an emphasis in chemistry, biology or physics or a completed animal husbandry program
  • One year of related experience, or equivalent in education, training and experience
  • Must be detail oriented and possess excellent interpersonal, organizational and communication skills.
  • Must be self-motivated, able to multi-task, work independently as well as part of a team, and work well under pressure.
  • Proficiency with Microsoft Word, Excel, PowerPoint and data management files required.

Other Requirements

The candidate selected for this position is required to undergo a drug screening test prior to a final offer of employment being made

  • Position will involve work with laboratory animals
  • Potential bloodborne pathogen exposure
  • Participation in the medical surveillance program
  • Successful completion of applicable compliance and systems training requirements

Candidates should apply online here.

 

Equal Opportunity Employer / Disability / Veteran

Columbia University is committed to the hiring of qualified local residents.