Adam D. Griesemer, MD

Academic Appointments

  • Assistant Professor of Surgery at CUMC

Current Administrative Positions

  • Surgical Director, Pediatric Liver Transplantation
  • Surgical Director, Living Donor Liver Transplantation-Columbia Campus
  • Director, Large Animal Xenotransplantation Laboratory, Columbia Center for Translational Immunology
Adam D. Griesemer, MD

Allogeneic Studies

My laboratory is investigating the ability of ex-vivo expanded Tregs to enhance bone marrow engraftment and extend the duration of mixed chimerism. The induction of durable mixed chimerism without graft-versus-host disease should in turn lead to life-long donor-specific tolerance to any co-transplanted cells (islets) or solid organs (heart, liver, lung) from the donor. We are also collaborating with other investigators at the CCTI to study the ability of amnion-derived multipotent progenitor cells to enhance bone marrow engraftment in translational models as an alternate, and potentially synergistic, strategy to induce durable mixed chimerism.

We are also investigating the ability to translate the induction protocol that induces tolerance to simultaneously co-transplanted bone marrow and kidney grafts (despite only transient mixed chimerism developing) to combined bone marrow and liver grafts. In particular, we are investigating 1) the role of donor and recipient memory cells in mediating host-versus-graft and graft-versus-host responses; and 2) the role that inflammatory cytokines, particularly in the portal system, play in priming inflammatory and tolerogenic cellular responses.

The future goals of the laboratory include collaborating with the Chen lab in testing the ability of durable mixed chimerism to induce tolerance to organs that do not facilitate tolerance with the transient mixed chimerism approach, such as islets. We also plan to test the ability of modulating the T cell memory responses and the inflammatory environment induced after liver transplant to reliably induce rapid tolerance after liver transplants.

Xenogeneic Studies

The development of Gal-knockout swine removed the most significant target of natural antibodies from the surface of pig cells. However, low levels of non-Gal antibodies represent a barrier to long-term solid organ xenograft survival and xenogeneic bone marrow engraftment. Since pharmacological interventions have been unsuccessful in decreasing natural antibody levels, my lab is investigating the efficacy of Treg therapy in reducing anti-swine antibodies and facilitating tolerance induction to xenotransplants.

Current investigations include:

1. Studies on the optimal method of stimulating Tregs during expansion to generate donor-specific Tregs

2. Suppression of xenogeneic natural antibodies by donor-specific Tregs in preclinical models

3. Augmentation of xenogeneic chimerism using donor-specific Tregs

The future goals of the laboratory are to utilize donor-specific Tregs to control the natural anti-swine antibody response in translational swine-to-humanized mice and swine-to-nonhuman primate models. This in turn will facilitate the induction of xenogeneic chimerism that is expected to result in robust tolerance to donor solid organ transplants.

Departments and Divisions

  • Department of Surgery

Education and Training

  • University of Missouri Columbia School of Medicine
  • BA, Harvard University
  • Residency: NewYork-Presbyterian Hospital/Columbia University Medical Center
  • Fellowship: 2013 Department of Surgery, Columbia University, Abdominal Organ Transplant Fellow

Lab Locations

  • CUMC/Presbyterian Hospital and Vanderbilt Clinic

    622 West 168th Street
    14 PH
    New York, NY 10032

Contact Info

  • (212) 305-9691

Past Positions

  • Abdominal Organ Transplant Fellowship, NewYork-Presbyterian/Columbia University Medical Center, New York, NY, 2011-2013
  • Research Fellow, Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, 2011
  • Resident, General Surgery, NewYork-Presbyterian/Columbia University Medical Center, New York, NY, 2008-2011
  • Research Fellow, Transplantation Biology and Xenotransplantation, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2005-2008
  • Resident, General Surgery, NewYork-Presbyterian/Columbia University Medical Center, New York, NY, 2004-2005
  • Internship, General Surgery, NewYork-Presbyterian/Columbia University Medical Center, New York, NY, 2003-2004

Presentations

  • High Levels of Cytotoxic Anti-Non Gal Preformed Natural Antibody Did Not Induce Hyperacute Rejection But Did Cause Early Graft Loss in A Galt-KO Pig-To-Baboon Thymokidney Model. Nishimura H, Shimizu A, Griesemer A, Scalea J. R, Moran S, Weiner J, Gillon B, Fishman J, Robson S. C, Sykes M, Sachs D. H, Yamada K. Presentation at 2010 ATC.
  • Quantification of Baboon Thymopoiesis in Porcine Thymokidney Xenografts By A Signal Joining Tcr Excision Circle (Sjtrec) Assay. Tena A, Vallabhajousula P, Hawley R. J, Griesemer A, Yamada K, Sachs D. H. Presentation at the 2010 ATC.
  • Specific Humoral Non-Responsiveness To Swine Antigens and Engraftment Following Administration of Galt-Ko Porcine Bone Marrow To Baboons. Liang F, Griesemer A, Scalea J. R, Wamala I, Tena A, Moran S, Yamada K, Huang C, Sachs D. H. Presentation at the 2010 ATC.
  • Optimal T Cell Depletion Is Essential for Successful Thymokidney Transplants in Galt-Ko Pig To Baboon Model. Yamada K, Nishimura H, Scalea J. R, Griesemer A, Moran S, Gillon B, Robson S, Fishman J, Sykes M, Shimizu A, Sachs D. H. Presentation at the 2010 ATC.
  • Average survival greater than 50 days in baboon recipients of life-supporting GalT-KO pig thymokidneys. Griesemer A, Iwaki H, Hirakata A, Ishikawa Y, Moran S, Schule P, Arn S, Shimizu A, Sachs D, Yamada K. Oral Presentation at the 2008 ATC. Young Investigator Award (Griesemer).
  • Composite Islet-Kidneys reverse diabetes across a fully allogenic barrier in nonhuman primates. Iwaki H, Hirakata A, Griesemer A, Tchipashvili V, Ishikawa Y, Shimizu A, Sachs D, Yamada K. Oral Presentation at the 2008 ATC. Young Investigator Award (Iwaki).
  • Tolerance and long-lasting peripheral chimerism following allogeneic intestinal transplantation in MGH miniature swine. Ishikawa Y, Hirakata A, Griesemer A, Etter J, Iwaki H, Shimizu A and Yamada Poster Presentation at the 2008 ATC.
  • The thymus plays an important role in breaking tolerance to renal allografts in miniature swine. Griesemer A, Ishikawa Y, Hirakata A, Okumi M, Etter, J, Iwaki H, Shimizu A, Sachs D, Yamada K. Poster Presentation at the 2008 ATC.
  • Xenogeneic thymokidney transplantation using GalT-KO swine produced by conventional breeding. Griesemer A, Hirakata A, Arn S, Shimizu A, Duggan M, Hanekamp J, Moran SG, Sachs DH and Yamada K. Oral Presentation at the CTS-IPITA-IXA 2007 Joint Conference.
  • Composite thymo-islet-kidneys induce tolerance and cure surgically induced diabetes. Griesemer A, Hirakata A, Okumi M, Shimizu A, Etter J, Sachs DH and Yamada K. Oral Presentation at the CTS-IPITA-IXA 2007 Joint Conference, Young Investigator Award (Griesemer).
  • Composite islet-kidneys from single donors cure diabetes across fully allogeneic barrier in nonhuman primates. Hirakata A, Griesemer A, Tchipashvili V, Shimizu A, Sachs DH and Yamada K. Poster presentation at the CTS-IPITA-IXA 2007 Joint Conference.
  • Linked suppression of the immune response to renal transplants across a fully MHC-mismatched barrier in miniature swine. Griesemer A, Hirakata A, Shimizu A, Okumi M, Moran S, Etter J, Caputo L, Sachs DH, Yamada K. Poster Presentation at the American Transplantation Congress 2007, Poster of Distinction.
  • Specific Non-Responsiveness to Pig in Baboons Receiving BMT from GaIT-KO Pigs. Ghazi A, Griesemer A, Hirakata A, Hirsh E, Lo D, Okumi M, Sykes M, Sachs DH, Yamada K, Huang CA. Poster Presentation at the American Transplantation Congress 2007.
  • Allosensitization does not increase the risk of xenoreactivity to α1,3-galactosyltransferase gene knockout miniature swine in patients on transplantation waiting lists. Griesemer A, Wong B, O'Malley P, Okumi M, Tseng Y, Weiner J, Hirakata A, Dor F, Cooper D, Sachs D, Yamada D. Oral Presentation at the World Transplantation Congress 2006.
  • Transplanted kidney is more sensitive to hyperglycemic injury than native kidney in diabetic miniature swine. Hirakata A, Shimizu A, Griesemer A, Okumi M, Sachs D, Colvin R, Yamada K. Poster Presentation at the World Transplantation Congress, 2006.
  • Gal knockout miniature swine produce anti-gal antibodies and demonstrate accommodation to Gal positive kidneys. Griesemer A, Moran S, Okumi M, Shimizu A, Hirakata A, Iorio J, McMorrow I, Yamada K. Oral Presentation at the World Transplantation Congress, 2006.
  • Thymic rejuvenation II: Aged vascularized thymic lobe grafts are capable of inducing tolerance tolerance in juvenile miniature swine across a class I MHC mismatch. Yamada K, Nobori S, Okumi M, Griesemer A, Hirakata M, Moran S, Iorio J, Shimizu A, Sachs D. Poster presentation at the World Transplantation Congress, 2006.
  • Thymic Rejuvenation I: Factors extrinsic to the thymus determine thymic structure and function. Yamada K, Nobori S, Shimizu A, Okumi M, Griesemer A, Hirakata A, Moran S, Sachs D. Poster presentation at the World Transplantation Congress, 2006.
  • Successful transfer of tolerance by adoptive transfer in miniature swine. Okumi M, Griesemer A, Hirakata A, Nobori S, Madsen J, Shimizu A, Sachs D, Yamada K. Oral presentation at the World Transplantation Congress, 2006.
  • Linked suppression across an MHC-mismatched barrier in a miniature swine kidney transplantation model. Griesemer A, Okumi M, Hirakata A, Shimizu A, Sachs D, Yamada K. Oral Presentation at the World Transplantation Congress, 2006
  • Effect of sensitization and persistence of donor antigen on the maintenance of tolerance to renal allografts in miniature swine. Okumi M, Griesemer A, Hirakata A, Nobori S, Shimizu A, Sachs D, Yamada K. Oral Presentation at the World Transplantation Congress, 2006. Young Investigator Award (Okumi)
  • Generation of human anti-pig specific regulatory T cells by blockade of B7/CD28 co-stimulatory pathway. Hirakata A, Okumi M, Griesemer A, Yamada K. Poster Presentation at the World Transplantation Congress, 2006.
  • Transmyocardial Revascularization Surgery: A Two-Year Follow-Up. Griesemer A. Mundis G. Somasegaran V. Richman B. Jones JW. American College of Surgeons-Missouri Chapter, 2001. 1st Place, medical student oral presentation

Committees / Societies / Memberships

  • Grant's Committee, ASTS, 2017-Current
  • Clinical Subcommittee, NIH Human Immunology Project Consortium, 2017-Current
  • NIAID-NHP Transplantation Tolerance Cooperative Study Group, 2017-Current
  • Scientific Studies Committee, ASTS, 2013-2017
  • American Association for the Study of Liver Diseases, 2013- present
  • American Society of Transplant Surgeons, 2010- present
  • The Transplantation Society, 2007- present
  • International Xenotransplantation Association, 2007-present
  • American Society of Transplantation, 2005-present

Honors and Awards

  • 2020 New York Super Doctors
  • 2020 Rising Star in Transplant Surgery, American Society of Transplant Surgery 2020
  • 2019 Co-Chair, Surgical Committee of The Starzl Network for Excellence in Pediatric Transplantation
  • 2018 Faculty Development Grant, American Society of Transplant Surgeons
  • 2017 Nominated for Physician of the Year by Surgical Intensive Care Unit
  • 2015 AASLD Career Development Award in Liver Transplantation
  • 2013 Forde Award for Research, Columbia University
  • 2013 Department of Surgery's Chairman's Research Award, Columbia University College of Physicians and Surgeons
  • 2013 Louis V. Gerstner, Jr. Scholar – Research Award, Columbia University College of Physicians and Surgeons
  • 2011 Blakemore Prize - Best Resident Research Award, Columbia University College of Physicians and Surgeons
  • 2010 Administrative Chief Resident in General Surgery, Columbia University
  • 2009 Blakemore Award - Best Resident Research Award, Columbia University College of Physicians and Surgeons
  • 2008 American Society of Transplantation Young Investigator Award, Transplantation Biology Research Center, Harvard Medical School
  • 2007 International Xenotransplantation Travel Grant, Transplantation Biology Research Center, Harvard Medical School
  • 2005 American Society of Transplantation/JDRF Research Fellowship Award, Transplantation Biology Research Center, Harvard Medical School
  • 2003 Alpha Omega Alpha, University of Missouri-Columbia School of Medicine
  • Marion DeWeese Award for Excellence in General Surgery, University of Missouri-Columbia

Research Interests

  • Allogeneic tolerance induction
  • Control of humoral rejection
  • Small for Size Syndrome after Living Donor Liver Transplantation
  • Use of Tregs to control natural antibody responses and facilitate xenogeneic bone marrow engraftment
  • Xenogeneic tolerance induction via mixed chimerism and thymus transplant

NIH Grants

  • A PROSPECTIVE RANDOMIZED MULTI-CENTER STUDY OF THE USE OF THE LIFEPORT? LIVERTRANSPORTER (LLT) SYSTEM WITH VASOSOL? AS COMPARED TO STATIC COLD STORAGE IN ORTHOTOPIC LIVER TRANSPLANTS (PILOT?: PERFUSION TO IMPROVE LIVER OUTCOMES IN TRANSPLANTATION). (P&S Industry Clinical Trial)

    Jul 1 2019 - Jul 1 2024

    REGULATORY T CELLS TO PROMOTE MIXED CHIMERISM FOR TOLERANCE TO ISLETS ANDKIDNEYS FROM DECEASED AND LIVING DONORS (Federal Gov)

    Aug 18 2017 - Jul 31 2022

    DEVELOPMENT OF LUNG T CELL RESPONSES IN INFANT RESPIRATORY IMMUNITY (Federal Gov)

    Aug 1 2017 - Jul 31 2022

    HUMAN ANTI-VIRAL IMMUNE RESPONSES IN TISSUES AND CIRCULATION (Federal Gov)

    Jan 1 2017 - Dec 31 2021

    A TOLERANCE APPROACH TO XENOTRANSPLANTATION (Federal Gov)

    Aug 1 2017 - Jul 31 2021

    ROBUST ALLOGRAFT TOLERANCE IN NON-HUMAN PRIMATES (Federal Gov)

    Jul 1 2015 - Mar 31 2021

    MECHANISMS OF LIVER TRANSPLANT TOLERANCE AND ALLOREACTIVITY IN A TRANSLATIONAL MODEL (Private)

    Jul 1 2018 - Jun 30 2020

    REGENERON IPET STUDY (Private)

    Apr 3 2019 - Apr 2 2020

    ROBUST ALLOGRAFT TOLERANCE IN NON-HUMAN PRIMATES (Federal Gov)

    Jul 1 2015 - Mar 31 2020

    ROBUST ALLOGRAFT TOLERANCE IN NON-HUMAN PRIMATES (Federal Gov)

    Jul 1 2015 - Mar 31 2020

    GENERATION OF ANTI-DONOR CAR TREGS TO ENHANCE MIXED CHIMERISM AND TOLERANCE TO DECEASED DONOR KIDNEY TRANSPLANTS (Federal Gov)

    Sep 1 2018 - Jul 31 2019

    A TOLERANCE APPROACH TO XENOTRANSPLANTATION (Federal Gov)

    Aug 6 2015 - Aug 5 2018

    A TOLERANCE APPROACH TO XENOTRANSPLANTATION (Private)

    Aug 6 2015 - Aug 5 2018

    IMPROVING ENGRAFTMENT AND SURVIVAL OF PIG ISLET XENOGRAFTS THROUGH TRANSGENIC EXPRESSION OF HUMAN CD47 (Private)

    Mar 1 2017 - Feb 28 2018

    TOLERANCE TO VASCULARIZED ALLOGRAFTS IN MINISWINE (Federal Gov)

    Apr 1 1991 - Jan 31 2018

    ESTABLISHMENT OF DONOR CHIMERISM USING ALLOGENEIC BONE MARROW WITH AMP CELL CO-INFUSION (Federal Gov)

    Aug 15 2015 - Aug 14 2017

    A TOLERANCE APPROACH TO XENOTRANSPLANTATION (Federal Gov)

    Sep 1 2001 - Jul 31 2017

    IMMUNE RESPONSE TO COMBINED LIVER AND BONE MARROW TRANSPLANT OR TOLERANCE IN NHP (Federal Gov)

    Aug 19 2016 - Jul 31 2017

    2016 ASTS PRESIDENTIAL STUDENT MENTOR GRANT (Private)

    Jul 1 2016 - Jun 30 2017

    CAREER DEVELOPMENT AWARD IN LIVER TRANSPLANTATION IN MEMORY OF THE UNIVERSITY OF MICHIGAN TRANSPLANT TEAM (Private)

    Jul 1 2015 - Jun 30 2017

    A TOLERANCE APPROACH TO XENOTRANSPLANTATION (Federal Gov)

    Sep 1 2001 - Jun 30 2016

    TOLERANCE TO VASCULARIZED ALLOGRAFTS IN MINISWINE (Federal Gov)

    Jul 1 2015 - May 31 2016

Lab Members

  • Nathaly Llore, MD, Postdoctoral Researcher
  • Paula Alonso-Guallart, DVM, Postdoctoral Researcher
  • Karina Bruestle, MD, Postdoctoral Researcher
  • Hiroshi Sakai, MD, Postdoctoral Researcher
  • Emily Lopes, Lab Technician
  • Genevieve Pierre, Lab Technician
  • Karl Erik Berglund, MD, Postdoctoral Researcher

Publications

  1. Sakai H, Duggan E, Griesemer A. Size isn’t everything: “Small” LDLT grafts can have good outcomes. Transplantation 2020. Invited Commentary, In Press.
  2. Bruestle K, Griesemer A. Pediatric Liver Transplantation in a Center That is Neither East Nor West. Annals of Surgery 2020. In Press.
  3. Alonso-Gullart P, Llore N, Lopes E, Kofman S, Ho S, Stern J, Pierre G, Bruestle K, Tang, Q, Sykes M, Griesemer A. CD40L-stimulated B cells for ex vivo expansion of polyspecific nonhuman primate regulatory T cells for translational studies. Clinical and Experimental Immunology. 2020 In Revision.
  4. Duggan EM, Griesemer A. Progress towards xenogeneic tolerance. Current Opinion in Organ Transplantation 2020. PMID: 32796179
  5. Hozain AE, O’Neill JD, Pinezich MR, Tipograf U, Donocoff R, Cunningham KM, Tumen A, Fung K, Ukita R, Simpson M, Reimer JA, Ruiz EC, Queen D, Stokes JW, Cardwell NK, Talackine J, Snoeck H, Chen Y, Romanov, A, Marboe CC, Griesemer AD, Guenthart BA, Bacchetta M, Vunjak-Novakovic G. Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs. Nature Medicine. 2020 Jul;26(7):1102-1113. PMID: 32661401
  6. Kato T, Hwang R, Liou P, Weiner J, Griesemer A, Samstein B, Halazun K, Mathur A, Schwartz G, Cherqui D, Emond J. Ex vivo resection and autotransplantation for conventionally unresectable tumors – an 11-year single center experience. Annals of Surgery. 2020. PMID: 32833756
  7. Heinz N, Griesemer A, Kinney J, Vittorio J, Lagana S, Golder D, Velasco M, Kato T, Lobritto S, Martinez M. A case of infant with SARS-CoV-2 hepatitis early after liver transplantation. Pediatric Transplantation. 2020. PMID: 32559354, PMCID: PMC7323125
  8. Lagana SM, De Michele S, Lee MJ, Emond JC, Griesemer AD, Tulin-Silver SA, Verna EC, Martinez M, Lefkowitch JH. COVID-19 Associated Hepatitis Complicating Recent Living Donor Liver Transplantation. Archives of Pathology and Laboratory Medicine. 2020 Apr 17. PMID: 32302212
  9. Chaudhry S, Kato Y, Weiner J, Alonso-Guallart P, Baker S, Woodland DC, Lefkowitch JH, Duran-Struuck R, Sondermeijer HP, Zitsman J, Sears ML, Wu A, Karolewski B, Houck PJ, Martinez M, Kato T, Sykes M, Griesemer AD. In contrast to kidney, liver allograft tolerance is not achieved with a transient mixed chimerism regimen in nonhuman primates. Transplantation. 2020 Apr 6. Epub ahead of print. PMID: 32265416
  10. Winer L, Vivero M, Scully B, Cortez A, Kassam A, Nowygrod R, Griesemer A, Emond JE, Quill-in R. Exploring medical students' perceptions of organ procurement: Need for a formalized medical student curriculum. Journal of Surgical Education. J Surg Educ. 2019 Nov 18. PMID: 31753606
  11. Sell-berg F, Berglund D, Binder C, Hope J, Fontenot J, Griesemer A, Sykes M, Sachs DH, Berglund E. Pharmacokinetic and pharmacodynamic study of a clinically effective anti-CD2 monoclonal antibody. Scand J Immunol. 2019 Oct 20:e12839. PMID: 31630416
  12. Berglund E, Alonso-Guallart P, Danton M, Sellberg F, Binder C, Fröbom R, Berglund D, Llore N, Sakai H, Iuga A, Ekanayake-Alper D, Reimann KA, Sachs DH, Sykes M, Griesemer A. Safety and pharmacodynamics of anti-CD2 monoclonal antibody treatment in cynomolgus macaques. Transpl Int. 2019 Sep 15. PMID: 31523849

For a complete list of publications, please visit PubMed.gov